PrPSc Inhibition and Cellular Protection of DBL on a Prion-Infected Cultured Cell via Multiple Pathways

Αnti-prion effects of anthocyanins

“…Oxidative stress has been identified as a hallmark of neurodegeneration [ 32 , [129] , [130] , [131] ]. In accordance with other anti-oxidant compounds exhibiting anti-prion activity [ 72 , 124 , 126 , 128 , 132 , 133 ], Oenin and Myrtillin successfully decreased the levels of ROS in prion-infected cells. While Oenin didn't affect Nrf2 expression levels, it managed to activate the Keap1-Nrf2 pathway (albeit less effectively compared to Myrtillin).…”