PrPSc in mammary glands of sheep affected by scrapie and mastitis

Ligios, Ciriaco; Sigurdson, Christina J.; Santucciu, Cinzia; Carcassola, G.; Manco, Giuseppe; Basagni, M.; Maestrale, Caterina; Cancedda, Maria Giovanna; Madau, Laura; Aguzzi, Adriano

doi:10.1038/nm1105-1137

Cited by 144 publications

(119 citation statements)

References 8 publications

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“…Furthermore, PrP Sc was associated with lymphoid follicles from the mammary gland of four mastitic ewes with clinical scrapie, but was not detected in scrapie affected non-mastitic ewes [51]. Hence there is a concern that PrP Sc could be detected in milk of animals with high somatic cell counts in milk or suffering from mastitis.…”

Section: Mastitis/somatic Cell Countsmentioning

confidence: 97%

The evidence of associations between prion protein genotype and production, reproduction, and health traits in sheep

Sweeney

Hanrahan

2008

Vet. Res.

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Section: Mastitis/somatic Cell Countsmentioning

confidence: 97%

The evidence of associations between prion protein genotype and production, reproduction, and health traits in sheep

Sweeney

Hanrahan

2008

Vet. Res.

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“…Despite the fact that infectivity has been never been found in any secreta or excreta of scrapie infected sheep (reviewed in [27]), it does not exclude possible low levels of infectivity in milk, saliva, faeces, or urine of scrapieinfected sheep. PrP Sc detection in ectopic lymphoid tissue in the mammary gland [41], in the renal papillae [59], and in the salivary glands of scrapie-infected sheep [69] have raised questions about the possible role of milk, urine, and saliva in the transmission of scrapie.…”

Section: Shedding Of the Infectious Agentmentioning

confidence: 99%

TSE pathogenesis in cattle and sheep

2008

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-Many studies have been undertaken in rodents to study the pathogenesis of transmissible spongiform encephalopathies (TSE). Only a few studies have focused on the pathogenesis of bovine spongiform encephalopathy (BSE) and scrapie in their natural hosts. In this review, we summarize the most recent insights into the pathogenesis of BSE and scrapie starting from the initial uptake of TSE agents and crossing of the gut epithelium. Following replication in the gut-associated lymphoid tissues (GALT), TSE agents spread to the enteric nervous system (ENS) of the gut. Infection is then carried through the efferent fibers of the post-ganglionic neurons of the parasympathetic and sympathetic nervous system to the pre-ganglionic neurons in the medulla oblongata of the brain and the thoracic segments of the spinal cord. The differences between the pathogenesis of BSE in cattle and scrapie in sheep are discussed as well as the possible existence of additional pathogenetic routes.

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“…The results of our work have an added value as they have a broader application because conclusions are based on more than 10,000 sheep from different flocks. The relationship between both diseases has been demonstrated at the pathological level in several independent previous reports in both sheep and goats (Ligios et al, 2005;González et al, 2010;Salazar et al, 2010). Indeed, VMV-related lymphoproliferative pneumonia or mastitis favour the accumulation of PrP Sc in the target organ.…”

Section: Discussionmentioning

confidence: 78%

Lack of relationship between Visna/maedi infection and scrapie resistance genetic markers

Salazar¹,

Berriatua²,

Pérez³

et al. 2014

Span. j. agric. res.

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The relationship between Visna/maedi virus (VMV) antibody status and scrapie genetic resistance of 10,611 Rasa Aragonesa sheep from 17 flocks in Aragón (Spain) was investigated. The fifteen most common PRNP gene haplotypes and genotypes were identified and the genotypes were classified into the corresponding scrapie risk groups (groups 1 to 5). ARQ (93.3%) and ARR (31.8%) were the most common haplotypes and ARQ/ARQ (56%) and ARR/ARQ (25.6%) were the most common genotypes. The frequencies of scrapie risk groups 1, 2, 3, 4 and 5 were 3.3%, 27.3%, 63.5%, 1.2% and 4.8%, respectively. Overall Visna/maedi seroprevalence was 53% and flock seroprevalence ranged between 21-86%. A random effects logistic regression model indicated that sheep VMV serological status (outcome variable) was not associated with any particular scrapie risk group. Instead, VMV seropositivity progressively increased with age, was significantly greater in females compared to males and varied between flocks. The absence of a relationship between VMV infection and scrapie genotypes is important for VMV control and specifically for sheep participating in an ELISA-based Visna/maedi control program.

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PrPSc in mammary glands of sheep affected by scrapie and mastitis

Cited by 144 publications

References 8 publications

The evidence of associations between prion protein genotype and production, reproduction, and health traits in sheep

The evidence of associations between prion protein genotype and production, reproduction, and health traits in sheep

TSE pathogenesis in cattle and sheep

Lack of relationship between Visna/maedi infection and scrapie resistance genetic markers

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