PRPF8 regulates FAK/AKT pathway and cytoskeleton remodeling through modulation of fibronectin 1 splicing in liver pathologies

Hermán‐Sánchez, Natalia; Liu, Juan; Mercedes, del Río-Moreno; Antonio, C Fuentes-Fayos; Marina, E. Sánchez-Frias; Víctor, Amado; Rubén, Ciria; Javier, Briceño; Manuel, de la Mata; Justo, Pilar; Manuel, Rodríguez-Perálvarez; Raúl, Marcos; Manuel, DD

doi:10.1530/endoabs.73.ep129

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“…For example, studies have reported that decreased expression of PRPF8 leads to increased cellular proliferation in K542 and CD 34+ cells [11]. The PRPF8 depletion disrupts Homology-Directed Repair (HDR), Single Strand Annealing (SSA), and end resection [12].In HCC caused by different causes, PRPF8 over expression is related to the invasion of HCC cell lines in vitro [13].…”

Section: Introductionmentioning

confidence: 99%

PRPF8 Expression is an Independent Predictor for Poor Prognosis in Patients with Kidney Renalclear Cell Carcinoma

Zhu¹,

Qiqi²,

Qi³

et al. 2022

austinjcancerclinres

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Background: Alternative splicing is an important process associated with disease including tumors. PRPF8 is a conserved protein in splice some component U5 snRNP that plays an important role in tumor cell growth. Materials and Methods: The data in The Cancer Genome Atlas was downloaded and analyzed by R Studio. The box plots showed the expression pattern of PRPF8. The chi-square test was used to manifest the association between PRPF8 expression and clinical parameters. The diagnostic value was assessed using ROC curve. The Kaplan-Meier curves and the Cox regression analysis elucidated the difference of overall survival and relapse-free survival between high expression and low expression and the prognostic value. Results: We downloaded the PRPF8 expression and the clinical data of 50 healthy individuals and 537 patients from TCGA database. We found PRPF8 expression is lower in tumor tissues than that in normal tissues and is related to age, histologic grade, pathologic stage, M classification, T classification and vital status. The Kaplan Meier curves showed the patients with lower PRPF8 expression has a poorer overall survival and relapse-free survival. The Univariate and Multivariate analysis suggested PRPF8 expression was an independent prognostic factor for overall survival and relapse-free survival in kidney renal clear cell carcinoma. Conclusion: Low PRPF8 expression is an independent predictor for overall survival and relapse-free survival in kidney renal clear cell carcinoma.

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Section: Introductionmentioning

confidence: 99%