Prp19 Is an Independent Prognostic Marker and Promotes Neuroblastoma Metastasis by Regulating the Hippo-YAP Signaling Pathway

Cai, Yuanxia; Chen, Kai; Cheng, Cheng; Xu, Yonghu; Cheng, Qianqian; Xu, Guofeng; Wu, Yeming; Wu, Zhixiang

doi:10.3389/fonc.2020.575366

Cited by 13 publications

(12 citation statements)

References 42 publications

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“…Hence, they suggested USP39 as an oncogenic factor that can play a pivotal role in human RCC treatment. Moreover, pre-mRNA processing factor (PRPF) 4B kinase 50 , pre-mRNA processing factor 19 (PRP19) 51 , 52 , and pre-mRNA processing factor 31 (PRP31) 53 are the other oncogenic factors that are involved in mRNA processing pathway. Furthermore, the central role of the factors mentioned above is reported in previous studies in invasiveness and metastatic of numerous malignancies, including prostate cancer, melanoma, hepatocellular carcinoma, and invasive ovarian cancer.…”

Section: Discussionmentioning

confidence: 99%

Nkx3-1 and Fech genes might be switch genes involved in pituitary non-functioning adenoma invasiveness

Khayer

Jalessi

Jahanbakhshi

et al. 2021

Sci Rep

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Non-functioning pituitary adenomas (NFPAs) are typical pituitary macroadenomas in adults associated with increased mortality and morbidity. Although pituitary adenomas are commonly considered slow-growing benign brain tumors, numerous of them possess an invasive nature. Such tumors destroy sella turcica and invade the adjacent tissues such as the cavernous sinus and sphenoid sinus. In these cases, the most critical obstacle for complete surgical removal is the high risk of damaging adjacent vital structures. Therefore, the development of novel therapeutic strategies for either early diagnosis through biomarkers or medical therapies to reduce the recurrence rate of NFPAs is imperative. Identification of gene interactions has paved the way for decoding complex molecular mechanisms, including disease-related pathways, and identifying the most momentous genes involved in a specific disease. Currently, our knowledge of the invasion of the pituitary adenoma at the molecular level is not sufficient. The current study aimed to identify critical biomarkers and biological pathways associated with invasiveness in the NFPAs using a three-way interaction model for the first time. In the current study, the Liquid association method was applied to capture the statistically significant triplets involved in NFPAs invasiveness. Subsequently, Random Forest analysis was applied to select the most important switch genes. Finally, gene set enrichment (GSE) and gene regulatory network (GRN) analyses were applied to trace the biological relevance of the statistically significant triplets. The results of this study suggest that “mRNA processing” and “spindle organization” biological processes are important in NFAPs invasiveness. Specifically, our results suggest Nkx3-1 and Fech as two switch genes in NFAPs invasiveness that may be potential biomarkers or target genes in this pathology.

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Section: Discussionmentioning

confidence: 99%

Nkx3-1 and Fech genes might be switch genes involved in pituitary non-functioning adenoma invasiveness

Khayer

Jalessi

Jahanbakhshi

et al. 2021

Sci Rep

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“…Overexpression of PRP19 in lung cancer cells also decreased cisplatin-induced and impaired cell migration and tumor growth [ 153 ]. Contrastingly, PRP19 expression correlated with bone marrow metastasis in neuroblastoma and was an overall adverse prognostic biomarker with a positive effect on cell migration [ 154 ]. Unanimously, however, work from many labs over the years has shown that depletion of NTC and PRP19-associated complexes is clearly detrimental to cancer cell resistance to genotoxic stress, and thus PRP19 inhibition could potentially improve the efficacy of treatment regimens by enhancing cell death and/or senescence.…”

Section: Discussionmentioning

confidence: 99%

The PRP19 Ubiquitin Ligase, Standing at the Cross-Roads of mRNA Processing and Genome Stability

Idrissou

Maréchal

2022

Cancers

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mRNA processing factors are increasingly being recognized as important regulators of genome stability. By preventing and resolving RNA:DNA hybrids that form co-transcriptionally, these proteins help avoid replication–transcription conflicts and thus contribute to genome stability through their normal function in RNA maturation. Some of these factors also have direct roles in the activation of the DNA damage response and in DNA repair. One of the most intriguing cases is that of PRP19, an evolutionarily conserved essential E3 ubiquitin ligase that promotes mRNA splicing, but also participates directly in ATR activation, double-strand break resection and mitosis. Here, we review historical and recent work on PRP19 and its associated proteins, highlighting their multifarious cellular functions as central regulators of spliceosome activity, R-loop homeostasis, DNA damage signaling and repair and cell division. Finally, we discuss open questions that are bound to shed further light on the functions of PRP19-containing complexes in both normal and cancer cells.

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“…Other poor prognostic biomarkers are limited to the aggressive profile of neuroblastomas, not ganglioneuroma. T hese include epit helia l-mesenchyma l t ra nsition (EMT)-related pre-mRNA processing factor 19 (Prp19) (56). The Bcl-2 gene, related to programmed cell death, encodes an oncoprotein that has been suggested to help the differentiation between ganglioneuroma/neuroblastoma based on Bcl-2 immunostaining, but currently it is not considered a relevant prognostic marker (57).…”

Section: Advanced Biomarkersmentioning

confidence: 99%

Adrenal ganglioneuroma: Prognostic factors (Review)

et al. 2021

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Ganglioneuroma, a rare neural crest-derived tumor, exhibits a benign profile in contrast to other neuroblastic tumors (neuroblastoma/ganglioneuroblastoma). Ganglioneuromas can be found anywhere autonomic ganglia are located, mostly abdominal/pelvic sites followed by the adrenal glands (one-third of cases), mediastinum/thorax and cervical area. Affecting especially children more than 10 years of age, Ganglioneuroma is either asymptomatic or may cause local compressive effects; rarely inducing nonspecific abdominal complains or arterial hypertension related to oversecretion of epinephrine/norepinephrine/dopamine. Despite a good prognosis, adrenalectomy is necessary in order to rule out a malignancy. Open procedure represents the standard therapeutic option; alternatively, centers with large laparoscopic pediatric experience and good stratification protocols have reported successful procedures. High uptake of I 123 -MIBG is associated with a more severe outcome in cases with increased mitotic index. In neuroblastic tumors, neuron-specific enolase >33 ng/ml, age at diagnosis <49 months, and blood vessel invasion indicate a poor prognosis. Concurrent extra-adrenal/adrenal ganglioneuroma is associated with a more severe prognosis; post-surgical complications are more frequent in non-adrenal vs. adrenal ganglioneuroma. Exceptionally, immune-mediated paraneoplastic neurologic syndromes have been reported: anti-N-methyl-D-aspartate receptor encephalitis and opsoclonus-myoclonus-ataxia syndrome. ROHHAD syndrome is the underlying cause in 40-56% of cases of neuroendocrine tumors including ganglioneuroma; 70% of tumors are diagnosed within the first 24 months after hypothalamic obesity onset, associated with a severe prognosis due to hypoventilation, sleep apnea, and dysautonomia. Recently, the PKB/AKT/mTOR/S6 pathway was identified as a tumorigenic pathway in pediatric ganglioneuroma, not in neuroblastoma; mTOR inhibitors are a potential option for pre-operatory tumor shrinkage. Pediatric adrenal ganglioneuroma has a good prognosis if adequately treated; its recognition requires adrenalectomy. Further development of specific biomarkers is needed. In the present article, we aimed to introduce a review of the literature involving adrenal ganglioneuroma based on a practical, multidisciplinary perspective of prognostic factors.

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Prp19 Is an Independent Prognostic Marker and Promotes Neuroblastoma Metastasis by Regulating the Hippo-YAP Signaling Pathway

Cited by 13 publications

References 42 publications

Nkx3-1 and Fech genes might be switch genes involved in pituitary non-functioning adenoma invasiveness

Nkx3-1 and Fech genes might be switch genes involved in pituitary non-functioning adenoma invasiveness

The PRP19 Ubiquitin Ligase, Standing at the Cross-Roads of mRNA Processing and Genome Stability

Adrenal ganglioneuroma: Prognostic factors (Review)

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