Abstract:The cellular prion protein (PrP c) is a determining factor in TSE pathogenesis, acting as substrate to the formation of abnormal, protease resistant PrP Sc. PrP c , which is widely expressed throughout the brain is encoded by the PRNP gene. It has long been accepted that polymorphisms occurring in the open reading frame specifically at positions 136, 154, 171 confer resistance/ susceptibility to scrapie infection in sheep and influence incubation times of the disease. 'Normal' cellular processing of PrP c incl… Show more
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