Proximity Labeling Expansion Microscopy (PL-ExM) resolves structure of the interactome
Sohyeon Park,
Xiaorong Wang,
Xiangpeng Li
et al.
Abstract:Elucidating the spatial relationships within the protein interactome is pivotal to understanding the organization and regulation of protein-protein interactions. However, capturing the 3D architecture of the interactome presents a dual challenge: precise interactome labeling and super-resolution imaging. To bridge this gap, we present the Proximity Labeling Expansion Microscopy (PL-ExM). This innovation combines proximity labeling (PL) to spatially biotinylate interacting proteins with expansion microscopy (Ex… Show more
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