Provoked Coronary Spasm Predicts Adverse Outcome in Patients With Acute Myocardial Infarction

Wakabayashi, Kohei; Suzuki, Hiroshi; Honda, Yuki; Wakatsuki, Daisuke; Kawachi, K; Ota, Kei; Koba, Shinji; Shimizu, Nobuyuki; Asano, Fuyuki; Sato, Tokutada; Takeyama, Youichi

doi:10.1016/j.jacc.2008.01.076

Cited by 42 publications

(30 citation statements)

References 15 publications

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“…[764][765][766][767] Smoking, which exacerbates coronary vasospasm, should be proscribed, and CCBs are first-line therapies 642 ; long-acting nitrates are also effective when combined with CCBs. 755,758 Statins improve endothelium-dependent vasodilation and can be useful in vasospastic angina.…”

Section: December 23/30 2014mentioning

confidence: 99%

2014 AHA/ACC Guideline for the Management of Patients With Non–ST-Elevation Acute Coronary Syndromes

Amsterdam¹,

Wenger²,

Brindis³

et al. 2014

Circulation

1,043

886

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Section: December 23/30 2014mentioning

confidence: 99%

2014 AHA/ACC Guideline for the Management of Patients With Non–ST-Elevation Acute Coronary Syndromes

Amsterdam¹,

Wenger²,

Brindis³

et al. 2014

Circulation

1,043

886

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“…116 Provoked CAS is an independent predictor of major adverse cardiac events. 132 The incidence of recurrent or persistent angina is high in the long term followup of patients with CAS; however, rates of AMI and cardiac mortality are low.…”

Section: Coronary Artery Spasmmentioning

confidence: 99%

Acute Myocardial Infarction in Women

Mehta¹,

Beckie²,

DeVon³

et al. 2016

Circulation

860

331

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Cardiovascular disease is the leading cause of mortality in American women. Since 1984, the annual cardiovascular disease mortality rate has remained greater for women than men; however, over the last decade, there have been marked reductions in cardiovascular disease mortality in women. The dramatic decline in mortality rates for women is attributed partly to an increase in awareness, a greater focus on women and cardiovascular disease risk, and the increased application of evidence-based treatments for established coronary heart disease. This is the first scientific statement from the American Heart Association on acute myocardial infarction in women. Sex-specific differences exist in the presentation, pathophysiological mechanisms, and outcomes in patients with acute myocardial infarction. This statement provides a comprehensive review of the current evidence of the clinical presentation, pathophysiology, treatment, and outcomes of women with acute myocardial infarction.

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“…Wakabayashi et al found that 140 of 240 patients (73%) with acute MI had coronary spasm in the infarct-related arteries or non-infarct-related arteries on acetylcholine provocation at 10-20 days after MI onset, and provoked spasm is 1 of the independent risk factors of MACE including ACS. 25 Another study reported that provoked coronary spasm using ergonovine was closely related to new MI onset and/or progression of coronary atherosclerosis. 26 Among 61 patients with recurrent ACS in the present study, unstable angina caused by coronary spasm was noted in 1 patient with morning onset acute MI and in 1 patient with acute MI onset between 00:00 and 05:59 hours.…”

Section: Clinical Outcome According To Acute MI Onset Timementioning

confidence: 99%

Impact of Morning Onset on the Incidence of Recurrent Acute Coronary Syndrome and Progression of Coronary Atherosclerosis in Acute Myocardial Infarction

Nakashima

Mashimo

Kurobe

et al. 2017

Circ J

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Background:The relationship between time of onset of acute myocardial infarction (MI) and long-term clinical outcome has not been completely understood. We hypothesized that morning onset acute MI may be associated with adverse cardiac events. Methods and Results:This study involved 663 patients who underwent primary percutaneous coronary intervention (PCI). The main outcome measures were cardiac death, recurrent acute coronary syndrome (ACS), and re-hospitalization for heart failure. Major adverse cardiac events (MACE) were defined as a composite of individual adverse outcomes. Morning onset acute MI occurred in 212 patients (32.0%); they had higher rates of recurrent ACS (13% vs. 8%, P=0.03) and MACE (21% vs. 14%, P=0.012) than the patients with other times of onset. The PCI rate for progressive lesions was also higher than for patients with other times of onset (23% vs. 14%, P=0.013). On multivariate Cox regression analysis, morning onset was an independent predictor of recurrent ACS, MACE, and PCI for progressive lesions, with adjusted hazard ratios of 1.34 (95% CI: 1.06-2.92, P=0.030), 1.51 (95% CI: 1.02-2.23, P=0.038), and 1.58 (95% CI: 1.03-2.42, P=0.037), respectively. Conclusions:Morning onset may be associated with increased risk of recurrent ACS and coronary atherosclerosis progression.

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Provoked Coronary Spasm Predicts Adverse Outcome in Patients With Acute Myocardial Infarction

Abstract: Provoked coronary spasm predicts adverse outcome in AMI patients.

Cited by 42 publications

References 15 publications

2014 AHA/ACC Guideline for the Management of Patients With Non–ST-Elevation Acute Coronary Syndromes

2014 AHA/ACC Guideline for the Management of Patients With Non–ST-Elevation Acute Coronary Syndromes

Acute Myocardial Infarction in Women

Impact of Morning Onset on the Incidence of Recurrent Acute Coronary Syndrome and Progression of Coronary Atherosclerosis in Acute Myocardial Infarction

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