Provocation‐Neutralization: A Two‐Part Study Part II. Subcutaneous Neutralization Therapy: A Multi‐Center Study

Abstract

Presented is a triple-blind crossover study that investigates the efficacy of subcutaneous neutralization food hypersensitivity therapy. Seven physicians and thirty-three patients from various parts of the country participated. Each patient underwent three 2-week treatment sessions, with 1 week off treatment between each session. During each treatment session, one injection a day was given. The injection consisted of a placebo for one 2-week session, and the active allergen during the other two sessions. The active dose was determined by earlier intracutaneous provocative food testing. The diet during the study period was not varied. Medication-symptom diaries were maintained and treatment result evaluations for both individual complaints and overall results were detailed on a standard form at the end of each treatment session. While the number of foods treated per patient varied from 1 to 13, the majority were treated with 3 to 5 foods. Treatment with the active medication was more efficacious than with placebo. A few patients' symptoms were aggravated with the active medication. This indicates a correct diagnosis, but incorrect treatment dose. In the clinical setting such adverse response should be reversed. Overall, neutralization subcutaneous treatment should be beneficial approximately 75% of the time, and further enhanced by supplemental diet manipulation.

Acute and long-term management of food allergy: systematic review

“…The same was true with cross‐reactive pollen extract and other extracts. However, the amount of food tolerated remained small and side‐effects were common. One randomized trial found no benefit .…”

“…Five randomized trials found no benefits in infants and one trial found no benefits in young adults (50-55). Subcutaneous immunotherapy 9 11 Five randomized trials and four other studies found improved tolerability in children and adults (56)(57)(58)(59)(60)(61)(62)(63). One trial found no benefits (64) Sublingual immunotherapy 5 0 Four trials found that sublingual immunotherapy was associated with improved tolerability for those with peanut and fruit allergies (65-68).…”

Asthma Management in a ‘Clean’ Environment: 2. Progress and Outcome in a Cohort of Patients

“…King ef uf. [22] found that a similarly titrated food 'vaccine' protected significantly against symptoms from trigger foods compared with placebo in a double-blind multi-centre study in rhinitis, including some patients who also had asthma. Boris ef af.…”

The role of alternative therapies in the treatment of allergic disease

“…The majority of patients with multiple allergies have been shown to suffer from psychiatric illness [75], allhough the coexistance of food intolerance must also be considered. Clinical ecology employs various techniques to diagnose 'allergy' such as provocation neutralization [76], and leucocytotoxic blood lests [77]. Additionally, it also employs several desensitization procedures such as neutralization therapy (the Miiler technique) and oral immunotherapy not to be confused with injection immunotherapy [78], and enzyme potentiated desensitization (EPD).…”