Provitamin A carotenoids are independently associated with matrix metalloproteinase-9 in plasma samples from a general population

Rydén, Mireille; Garvin, Peter; Kristenson, Margareta; Leanderson, Per; Ernerudh, Jan; Jonasson, Lena

doi:10.1111/j.1365-2796.2012.2534.x

Cited by 6 publications

(4 citation statements)

References 45 publications

(104 reference statements)

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“…The examination of the literature data regarding the correlations between antioxidants and MMPs profile shows controversial aspects. In fact, MMP-9 plasma levels are negatively associated with provitamin A carotenoids in a general population [47] while, in experimental models, the deficiency of vitamin A seems to be responsible for a gelatinase decrease without any variations of TIMPs [48]. In subjects with acute stroke the infusion of uric acid induced a decrease of total and active MMP-9 levels [49] and the treatment with antioxidants (polyethylene glycol-superoxide dismutase and N-acetyl-L-cysteine) reduces the MMP-9 activity in plasma and in aortic tissue homogenates of experimental models of diabetes mellitus [39] and the use of tempol (a ROS scavenger) reduces MMP-2 levels and its activity in aortic rings of animal models of renovascular hypertension [50].…”

Section: Discussionmentioning

confidence: 99%

Study of the Correlations among Some Parameters of the Oxidative Status, Gelatinases, and Their Inhibitors in a Group of Subjects with Metabolic Syndrome

Hopps

Presti

Montana

et al. 2014

Mediators of Inflammation

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Our aim was to examine some parameters of oxidative status, gelatinases, and their inhibitors and to evaluate their interrelationships in subjects with metabolic syndrome (MS). We enrolled 65 MS subjects, subdivided according to the presence or not of diabetes mellitus. We examined lipid peroxidation (expressed as thiobarbituric acid reacting substances, TBARS), protein oxidation (expressed as carbonyl groups), nitric oxide metabolites (NOx), total antioxidant status (TAS), MMP-2, MMP-9, TIMP-1, and TIMP-2. We found that MS subjects, diabetics and nondiabetics, showed an increase in TBARS, PC, and NOx. A significant decrease in TAS was observed only in nondiabetic MS subjects in comparison with diabetic MS subjects. We observed increased concentrations of MMP-2, MMP-9, TIMP-1, and TIMP-2, higher in diabetic subjects. Our data showed a positive correlation between TAS and MMP-2, TAS and MMP-9, and TAS and MMP-9/TIMP-1 and a negative correlation between TBARS and MMP-2 in diabetic MS subjects in the entire group. In MS subjects a prooxidant status and increased levels of gelatinases and their inhibitors are evident although the correlations between oxidative stress and MMPs or TIMPs are controversial and need further investigation.

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Section: Discussionmentioning

confidence: 99%

Study of the Correlations among Some Parameters of the Oxidative Status, Gelatinases, and Their Inhibitors in a Group of Subjects with Metabolic Syndrome

Hopps

Presti

Montana

et al. 2014

Mediators of Inflammation

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“…At this purpose, an inverse correlation between plasma levels of provitamin A carotenoids and matrix metalloproteinase-9 was found, suggesting that the benefits of these nutrients can be attributable to reduced degradation of the extracellular matrix in the arterial wall [33]. Lycopene assumed with the diet by using tomato juice, spaghetti sauce, and tomato oleoresin reduced serum lipid peroxidation and LDL-C oxidation although it was not able to decrease serum values of total cholesterol, LDL-C, or HDL-C. [34].…”

Section: Carotenoids and Cardiovascular Healthmentioning

confidence: 99%

Dietary Intake of Carotenoids and Their Antioxidant and Anti-Inflammatory Effects in Cardiovascular Care

Ciccone

Cortese

Gesualdo

et al. 2013

Mediators of Inflammation

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165

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Cardiovascular disease related to atherosclerosis represents nowadays the largest cause of morbidity and mortality in developed countries. Due to inflammatory nature of atherosclerosis, several studies had been conducted in order to search for substances with anti-inflammatory activity on arterial walls, able to exert beneficial roles on health. Researches investigated the role of dietary carotenoids supplementation on cardiovascular disease, due to their free radicals scavenger properties and their skills in improving low-density lipoprotein cholesterol resistance to oxidation. Nevertheless, literature data are conflicting: although some studies found a positive relationship between carotenoids supplementation and cardiovascular risk reduction, others did not find any positive effects or even prooxidant actions. This paper aimed at defining the role of carotenoids supplementation on cardiovascular risk profile by reviewing literature data, paying attention to those carotenoids more present in our diet (β-carotene, α-carotene, β-cryptoxanthin, lycopene, lutein, zeaxanthin, and astaxanthin).

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“…Large population-based, epidemiological studies have established that concentrations of plasma β-carotene are inversely correlated with the measures of obesity [13], [14], markers of inflammation [15]–[17], measures of insulin-sensitivity [18], and the metabolic syndrome [18], [19]. Moreover, plasma levels of β-carotene are significantly lower in patients with type 2 diabetes compared with non-diabetic subjects [14], [20].…”

Section: Introductionmentioning

confidence: 99%

The Concentration of β-Carotene in Human Adipocytes, but Not the Whole-Body Adipocyte Stores, Is Reduced in Obesity

et al. 2014

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We have examined the concentration of β-carotene in the fat of isolated abdominal subcutaneous adipocytes obtained from lean (BMI<23 kg/m2), non-obese with higher BMI (23≤BMI<28 kg/m2), obese (BMI≥28 kg/m2), and from a group of obese subjects with type 2 diabetes. The concentration of β-carotene was 50% lower in the adipocytes from the obese and obese/diabetic groups compared with the lean and non-obese groups. Interestingly, the total amount of β-carotene in the adipocyte stores of each subject was constant among all groups. Triacylglycerol constituted 92±1% (by weight) of the adipocyte lipids in the lean group and this was increased to 99±2% in the obese group with diabetes (p<0.05). The concentration of cholesteryl esters was in all cases <0.1 g per 100 g of total lipids, demonstrating that mature human adipocytes have negligible stores of cholesteryl ester. Our findings demonstrate that adipocyte concentrations of β-carotene are reduced in obese subjects. The lower concentrations in adipocytes from subjects with type 2 diabetes apparently reflect subjectś obesity. Our finding that whole-body stores of β-carotene in adipocytes are constant raises new questions regarding what function it serves, as well as the mechanisms for maintaining constant levels in the face of varied adipose tissue mass among individuals over a period of time.

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Provitamin A carotenoids are independently associated with matrix metalloproteinase-9 in plasma samples from a general population

Abstract: A carotenoids are independently associated with matrix metalloproteinase-9 in plasma samples from a general population., 2012, Journal of Internal Medicine. which has been published in final form at: http://dx.doi.org/10.1111/j. 1365-2796.2012

Cited by 6 publications

References 45 publications

Study of the Correlations among Some Parameters of the Oxidative Status, Gelatinases, and Their Inhibitors in a Group of Subjects with Metabolic Syndrome

Study of the Correlations among Some Parameters of the Oxidative Status, Gelatinases, and Their Inhibitors in a Group of Subjects with Metabolic Syndrome

Dietary Intake of Carotenoids and Their Antioxidant and Anti-Inflammatory Effects in Cardiovascular Care

The Concentration of β-Carotene in Human Adipocytes, but Not the Whole-Body Adipocyte Stores, Is Reduced in Obesity

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