Provisional Stenting for the Treatment of Bifurcation Lesions: In Vitro Insights

Ng, Chen Koon Jaryl; Paradies, Valeria; Vlachojannis, George; Toh, Han Wei; Leo, Hwa Liang; Wong, En Hou Philip; Foin, Nicolas; Ang, Hui Ying

doi:10.1007/s12265-020-10088-3

Cited by 3 publications

(2 citation statements)

References 8 publications

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“…However, use of FKBI for one-stent techniques remains controversial ( 14 ). FKBI may improve clinical outcomes in PCI by reducing “jailed” and floating struts after stent deployment in retrospective and in-vitro studies ( 15 , 16 ). However, other studies have shown the potential for kissing balloon inflation to cause overexpansion of the proximal segment of the stent in the main vessel, leading to elliptic deformations, impaired antiproliferative effects, reduced drug delivery, and increased restenosis risk ( 17 , 18 ).…”

Section: Introductionmentioning

confidence: 99%

Longitudinal outcomes of final kissing balloon inflation in coronary bifurcation lesions treated with a single stent

He,

Robb,

Martinez-Camblor

et al. 2023

Front. Cardiovasc. Med.

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BackgroundFinal kissing balloon inflation (FKBI) is a percutaneous coronary intervention (PCI) technique that is considered mandatory to improve outcomes in two-stent strategies, but its use in single-stent bifurcation PCI remains controversial.MethodsIn this retrospective cohort study, we identified patients with coronary bifurcation lesions treated with one stent from January 2012 to March 2021 at a single academic medical center. Incidence rates per 1,000 patient-years (IR1000) were calculated for the outcomes of all-cause mortality, myocardial infarction (MI), stent thrombosis (ST), target lesion revascularization (TLR), coronary artery bypass graft (CABG), and cardiac readmission between patients who received FKBI and those who did not over a median follow up of 2.3 years. Studied outcomes were adjusted for all baseline clinical and procedural characteristics.ResultsThis study included 893 consecutive patients of which 256 received FKBI and 637 did not. The IR1000 for MI were 51.1 and 27.6 for patients who received FKBI and patients who did not, respectively (adjusted HR = 2.44, p = 0.001). The IR1000 for death were 31.2 and 52.3 for patients who received FKBI and patients who did not, respectively (adjusted HR = 0.68, p = 0.141). The incidence rates of ST, TLR, CABG, and cardiac readmissions were similar between patients who received FKBI and those who did not.ConclusionsThese results suggest that performing FKBI in a one-stent technique was associated with higher rates of myocardial infarction, particularly in the first 6 months, and no difference in death, ST, TLR, CABG, and cardiac readmission rates.

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Section: Introductionmentioning

confidence: 99%

Longitudinal outcomes of final kissing balloon inflation in coronary bifurcation lesions treated with a single stent

He,

Robb,

Martinez-Camblor

et al. 2023

Front. Cardiovasc. Med.

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“…Coronary bifurcation lesions account for 15%-20% of percutaneous coronary interventions (PCIs). 1 Bifurcation lesions have a more complex anatomical structure, which results in higher incidence of postoperative instent restenosis than nonbifurcation lesions. 2,3 For most coronary bifurcation lesions, single stent implantation is the preferred procedure for PCI.…”

Section: Introductionmentioning

confidence: 99%

Influence of different postballoon expansion procedures: A finite element analysis

Cao

et al. 2022

Medical Physics

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Background: Postballoon expansion is considered as an appropriate procedure for adequate stent expansion for coronary bifurcation lesions. Two postballoon expansion procedures are currently recommended: proximal optimization technique (POT)/side/POT and POT/kiss/POT. However, the effects of the two postballoon expansion treatments are different. There is a lack of biomechanical study to quantify the difference. Purpose: It is recognized that biomechanical factors influence the occurrence of Major Cardiovascular Adverse Events (MACE), which includes recurrent angina pectoris, acute myocardial infarction and coronary heart disease death. The current paper evaluated the two postexpansion strategies and quantified biomechanical parameters to provide a basis for clinical decisions. Methods: Based on the CT angiography (CTA) data of a patient diagnosed with coronary bifurcation lesions, a personalized coronary bifurcation lesion model was constructed, and the surgical procedure after two expansions was simulated. The POT/side/POT and POT/kiss/POT expansion procedures were analyzed from the perspective of biomechanics through finite element analysis. The biomechanics factors, including the percentage of stent malapposition and stent occlusion at the side branch (SB) opening, the stent ellipse index of proximal main vessel (PMV) segment, the minimum lumen area of the stent vessel segment and the stress distribution of the vessel wall, were used to quantify clinician concerns about factors affecting patient outcomes. The factors include stent adhesion, SB open stent occlusion, poor stent deformation, patency effect of vessel stenosis, and vessel wall damage. Results: Both postexpansion procedures were successfully simulated. The malapposition rate during POT/side/POT was larger (1.2% vs. 0.42%) and stent occlusion at the SB opening from the cross-section perpendicular to the SB opening after the POT/side/POT procedure was 0.20%, compared with 0.00% after POT/kiss/POT.POT/kiss/POT produced a larger PMV segment stent ellipse index. Minimum lumen area after POT/side/POT was 5.6 mm 2 and after POT/kiss/POT 5.9 mm 2 . POT/kiss/POT produces an effect of greater vascular stress than POT/side/POT. Conclusion: Numerical simulations provide a quantitative analysis to inform clinicians of the differences between preoperative planning and surgical procedures. Biomechanical analysis of the differences between the two postexpansion strategies found that the POT/kiss/POT procedure resulted in better stent fit, less occlusion of the SB open stent and better vascular patency but also resulted in poor stent deformation and caused greater vessel wall stress.

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Provisional Strategy for Left Main Stem Bifurcation Disease

Paradies

Banning

Cao

et al. 2023

JACC: Cardiovascular Interventions

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Provisional Stenting for the Treatment of Bifurcation Lesions: In Vitro Insights

Cited by 3 publications

References 8 publications

Longitudinal outcomes of final kissing balloon inflation in coronary bifurcation lesions treated with a single stent

Longitudinal outcomes of final kissing balloon inflation in coronary bifurcation lesions treated with a single stent

Influence of different postballoon expansion procedures: A finite element analysis

Provisional Strategy for Left Main Stem Bifurcation Disease

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