Providing insight into the mechanism of action of cationic lipidated oligomers using metabolomics
Maytham Hussein,
Muhammad Bilal Hassan Mahboob,
Jessica R. Tait
et al.
Abstract:The increasing resistance of clinically relevant microbes against current commercially available antimicrobials underpins the urgent need for alternative and novel treatment strategies. Cationic lipidated oligomers (CLOs) are innovative alternatives to antimicrobial peptides and have reported antimicrobial potential. An understanding of their antimicrobial mechanism of action is required to rationally design future treatment strategies for CLOs, either in monotherapy or synergistic combinations. In the present… Show more
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