Providing fertility care to men seropositive for human immunodeficiency virus: reviewing 10 years of experience and 420 consecutive cycles of in vitro fertilization and intracytoplasmic sperm injection

Sauer, Mark V.; Wang, Jeff G.; Douglas, Nataki C.; Nakhuda, Gary S.; Vardhana, P.A.; Jovanovic, Vuk; Guarnaccia, Michael M.

doi:10.1016/j.fertnstert.2008.04.013

Cited by 75 publications

(60 citation statements)

References 25 publications

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“…Highly active antiretroviral therapy can reduce the viral burden in a person's serum and semen. Some centers have also adopted testing of sperm by using a polymerase chain reaction (PCR) assay to determine whether the virus is present in the washed sperm preparation, but the utility and effectiveness of this added step have been questioned by other centers that have eliminated PCR from their protocols [13][14][15][16][17]. Recent innovative approaches such as pre-exposure prophylaxis (PrEP) with antiretroviral drugs may reduce further the susceptibility of the uninfected female partner [14,18].…”

Section: Discussionmentioning

confidence: 99%

Yes, It is Possible

Allahbadia

2015

J Obstet Gynecol India

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Human immunodeficiency virus-serodiscordant couples are actively seeking reproductive assistance and often consider or practice unsafe measures to achieve pregnancy. Reproductive issues and concerns unique to these couples need to be addressed before treatment.Assisted reproduction techniques can minimize the risk of infection and complete families associated with serodiscordant couples. Since 1987, more than 4000 published attempts have been reported in which processed spermatozoa from HIV-seropositive men were used to establish pregnancy in HIV-seronegative women. When the female partner is HIV positive, intrauterine insemination (IUI) will suffice in order to prevent horizontal infection. However, when the male partner is HIV positive, a technique developed in Milan over 15 years ago, involving sperm washing, is used in order to minimize infection of the healthy partner. Some couples need further treatment, due to inherent infertility, with advanced reproductive technology (ART) procedures, such as IVF or ICSI. Recent innovative approaches such as pre-exposure prophylaxis

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Section: Discussionmentioning

confidence: 99%

Yes, It is Possible

Allahbadia

2015

J Obstet Gynecol India

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“…The authors were of the opinion that IVF-ICSI further reduced transmission of virus by minimising oocyte contact with seminal plasma and other cells. There also would be no exposure of mother to the man's [10].…”

Section: Artificial Reproductive Techniquesmentioning

confidence: 99%

HIV and Preconception- a Review

Hegde¹,

Kamath²,

Sharma³

2013

Med-Science

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“…In discordant couples (with the male partner being infected), intercourse without condom use at the time of ovulation to attempt conception could reduce but does not eliminate the risk of infecting the partner. According to one study, the reported seroconversion rate was 4.3% for couples that employed timed intercourse to attempt conception (Sauer et al, 2009). Couples should be counseled against this unsafe method as they could still infect their partner.…”

Section: Should Assisted Reproductive Technology Be Available For Hivmentioning

confidence: 99%

“…Couples should be counseled against this unsafe method as they could still infect their partner. For these instances of male-infected sero-discordant couples, specific methods for sperm preparation and testing (density gradient and swim-up technique to obtain sperm and PCR virus detection assay) have been described (Kambin et al, 2004;Sauer et al, 2009;Semprini et al, 1998). The final sperm sample was used only if it tested negative on these assays (Semprini et al, 1998).…”

Section: Should Assisted Reproductive Technology Be Available For Hivmentioning

confidence: 99%