Provenance and temporal variations in selected flavonoids in leaves of Cyclocarya paliurus

Fang, Shengzuo; Yang, Wanxia; Chu, Xiuli; Shang, Xianwen; ChengQi, She; Fu, Xiangxiang

doi:10.1016/j.foodchem.2010.07.095

Cited by 88 publications

(85 citation statements)

References 24 publications

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“…In contrast to previous studies (Scogings et al, 2004;Santos et al, 2006;Fang et al, 2011) the levels of all phenolics did not present any correlation with climatic changes, such as rainfall and temperature. Clusters I and IV have no significant differences in all phenol levels despite occurring in distinct seasons (Table 1).…”

Section: Resultscontrasting

confidence: 99%

“…Tannin and terpenoid amounts alter during the development of the plant and also as a response to environmental changes (Salminen et al, 2001;Salminen et al, 2004;Scogings et al, 2004;Santos et al, 2006;Solar et al, 2006;Fang et al, 2011). Previous studies showed the seasonal influence on the terpenoids composition of the E. uniflora leaves oil (Costa et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

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Influence of foliar nutrients on phenol levels in leaves of Eugenia uniflora

Santos¹,

Fortes²,

Ferri³

et al. 2011

Rev. bras. farmacogn.

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Eugenia unifl ora L., Myrtaceae, leaves contain high amounts of phenolic compounds which are responsible for several pharmacological activities. In order to evaluate the phenolics seasonal variation leaves were analysed on a monthly basis during the period of two years for the contents of hydrolysable tannins, total phenols, fl avonoids, and nutrients (N, P, K, S, Ca, Mg, Mn, Zn, Cu, and Fe). Results were correlated with climate conditions (rainfall, humidity, and mean temperature) by Principal Component and Cluster Analysis which allowed four groups to be distinguished with respect to the age of the leaves and the content of some metals. Young leaves were characterised by high levels of Zn and nitrogen whereas old leaves contained high levels of Fe and calcium, and both groups had moderate amounts of phenolics. Adult leaves were divided in two groups and results revealed that while one group had the highest levels of all phenols and lowest amounts of Mn and Cu, the other showed opposite quantities. The Canonical Correlation Analysis confi rmed a highly signifi cant negative correlation between phenol contents and Mn and Cu. These facts suggested that fl avonoids and tannins production depends of the amounts of foliar nutrients, Cu and Mn in particular, which are cofactors of enzymes involved in phenol degradation and lignin biosynthesis. This knowledge can improve this specie cultivation in order to enhance the phenolic compounds concentration.

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Section: Resultscontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Influence of foliar nutrients on phenol levels in leaves of Eugenia uniflora

Santos¹,

Fortes²,

Ferri³

et al. 2011

Rev. bras. farmacogn.

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“…Though AQLF contained higher contents of total flavonoids, reached to 3.60 mg/g, its total triterpenoids was the lowest among eleven provenances, only 4.66 mg/g. In this study, the content of isoquercitrin was 0.23 mg/g in HHF provenance, and it was much lower than the report from Fang et al (2011), likely caused by seedling ages and extraction methods. Therefore, JXS is selected to be the optimal provenance based on the quantification of seven bioactive compounds.…”

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confidence: 77%

“…(Figure 3 (b)). In the previous studies, only isoquercitrin, kaempferol and quercetin have been used as marker compounds of C. paliurus (Fang et al, 2011;Yang et al, 2009;Xie et al, 2003). Although kaempferol-3-O-α-L-rhamnopyranoside ), kaempferol-3-O-β-glucuronide (Zhang et al, 2005, arjunolic acid , cyclocaric acid B (Zhang et al, 2005) and pterocaryoside B (Cui and Li, 2012) have been identified as some compounds in C. paliurus, there are no reports on these compounds as markers in this plant.…”

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confidence: 99%

“…subarcticum). The temporal variations of the three selected compounds (quercetin, kaempferol, isoquercitrin) in the leaves of C. paliurus were determined by Fang et al (2011), who reported that the mean concentrations in most of the provenances reached the maxima in July and September. In this study, the leaves of C. paliurus collected in July and October also showed higher contents in three major flavonoids (Table 5).…”

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Simultaneous determination of flavonoids and triterpenoids in <i>Cyclocarya paliurus</i> leaves using high-performance liquid chromatography

Shang¹,

Zf²,

Zhao³

et al. 2015

Afr. J. Trad. Compl. Alt. Med.

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Background: Cyclocarya paliurus is an endangered plant and endemic to China. The leaves of C. paliurus have been used in drug formulations and as ingredients in functional foods in China. The aim of this study was to develop an effective method to extract most of the compounds and to establish a simplified HPLC analytical method to determine the contents of major bioactive compounds simultaneously. Materials and methods:High-performance liquid chromatography (HPLC) coupled with a photodiode array detector (PDA) was used for the simultaneous determination of the major flavonoids and triterpenoids in C. paliurus leaves.Results: Ultrasonic extraction in 100% methanol for 30 min was adopted as the optimal extraction method for C. paliurus leaves. The separation conditions were optimized using a Phenomenex C18 ODS column (250 mm × 4.6 mm, 5 µm) with a mobile phase of acetonitrile and 0.02% formic acid and a detection wavelength of 205 nm. The validation data indicated that this new HPLC analytical method successfully quantified the provenance and seasonal variations of seven major compounds (three flavonoids and four triterpenoids) in C. paliurus leaves. Conclusion:The study provided a novel and simplified approach to simultaneously determine the quantity of major flavonoids and triterpenoids in C. paliurus leaves. The results could promote the optimization of silvicultural systems for quality control of C. paliurus. Key words: Cyclocarya paliurus; HPLC; flavonoids; triterpenoidsAbbreviations: High-performance liquid chromatography (HPLC); photodiode array detector (PDA); total flavonoids content (TFC); total triterpenoids content (TTC). IntroductionCyclocarya paliurus (Batal.) Iljinskaja is an endangered plant endemic to China and a monotypic genus of the Juglandaceae family. C. paliurus is commonly called "sweet tea tree" because of the sweet taste of its leaves (Fang et al., 2006). Sweet tea tree is naturally distributed in many provinces of Southern China, including Anhui, Fujian, Guangxi, Henan, Hubei, Hunan, Jiangsu, Jiangxi, Sichuan, Guizhou and Zhejiang (Fang and Fu, 2007). The leaves of C. paliurus have been used as herbal tea for hundreds of years He et al., 2013), and were used for drug formulations in traditional Chinese medicine (TCM) or as ingredient of functional foods in China (Xie et al., 2010). The main chemical composition of C. paliurus leaves include flavonoids, triterpenoids, and polysaccharides . The extracts of C. paliurus were reported to have multiple beneficial effects, such as antihypertensive ), antihyperlipidemic (Wang et al., 2013Kurihara et al., 2003), antihyperglycemic (Wang et al.，2013；Li et al.，2011), antioxidant activity (Wang et al.，2013), and inhibitors of PTP1B (protein tyrosine phosphatase 1B) .Up to now, the raw materials of C. paliurus were harvested in the wild for herbal tea or nutraceutical products. As the market demand increased, the natural resources were seriously destroyed. More leaves must be produced within the plantation. Recently, a number of such plant...

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A metagenomic analysis of the modulatory effect of Cyclocarya paliurus flavonoids on the intestinal microbiome in a high‐fat diet‐induced obesity mouse model

et al. 2019

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BACKGROUND As a result of a low bioavailability, the majority of Cyclocarya paliurus flavonoids (CPF) remain in the large intestine where they accumulate to exert a modulatory effect on the intestinal micro‐ecology. Therefore, the present study investigated the modulatory effect of CPF on intestinal microbiota. RESULTS CPF dramatically ameliorated the obesity‐induced gut dysbiosis. A significant decrease (P < 0.05) was observed in the ratio of Firmicutes/Bacteroidetes after CPF treatment for 8 weeks. Moreover, Kyoto Encyclopedia of Genes and Genomes pathways of biosynthesis of amino acids, the two‐component system and ATP‐binding cassette transporters enriched the most differentially expressed genes after CPF intervention. CONCLUSION The results of the present study indicate that CPF might have prebiotic‐like activity and could be used as a functional food component with potential therapeutic utility to prevent obesity‐related metabolic disorders by manipulating the gut flora and affecting certain metabolic pathways, thus contributing to the improvement of human health. © 2019 Society of Chemical Industry

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Provenance and temporal variations in selected flavonoids in leaves of Cyclocarya paliurus

Cited by 88 publications

References 24 publications

Influence of foliar nutrients on phenol levels in leaves of Eugenia uniflora

Influence of foliar nutrients on phenol levels in leaves of Eugenia uniflora

Simultaneous determination of flavonoids and triterpenoids in <i>Cyclocarya paliurus</i> leaves using high-performance liquid chromatography

A metagenomic analysis of the modulatory effect of Cyclocarya paliurus flavonoids on the intestinal microbiome in a high‐fat diet‐induced obesity mouse model

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