Protracted febrile myalgia syndrome in familial Mediterranean fever

Şenel, Kazım; Melikoğlu, Meltem Alkan; Baykal, Tuba; Melikoğlu, Mehmet; Erdal, Akın; Uğur, Mahir

doi:10.1007/s10165-010-0288-4

Cited by 8 publications

(6 citation statements)

References 14 publications

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“…Steroid treatment may shorten the course of PFMS, but PFMS may recur despite colchicine prophylaxis. 4 Secondary amyloidosis, a common long-term complication of FMF, may be delayed by colchicine prophylaxis. Amyloid involvement of an allograft may occur after transplant in patients who have colchicine dosage reduced to 0.5 mg daily.…”

Section: Discussionmentioning

confidence: 99%

“…9 Myalgias, reported in 25% patients who have FMF, may be part of a spontaneous, exercise-induced, or protracted febrile myalgia syndrome (PFMS). [2][3][4] Colchicine-induced myotoxicity is well-described but a rare adverse event. 2 Neuromyopathy caused by colchicine can occur in patients who have an acute overdose or chronically administered therapeutic doses.…”

Section: Introductionmentioning

confidence: 99%

“…1,2 Acute attacks of FMF are accompanied by elevation in serum markers of systemic inflammation. 3,4 The disorder is inherited as an autosomal recessive trait and has been described in several ethnic groups primarily in the Mediterranean region: Sephardic Jews, Armenians, Turks, North Africans, Arabs, Greeks, and Italians. 1 However, the disease is not restricted to these groups.…”

Section: Introductionmentioning

confidence: 99%

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Halim¹,

Al-Otaibi²,

Donia³

et al. 2015

Exp Clin Transplant

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Drug-induced toxic myopathy is a complication of familial Mediterranean fever in patients who receive colchicine, especially when combined with cyclosporine. Protracted febrile myalgia syndrome is a severe form of familial Mediterranean fever. A 34-year-old man who had familial Mediterranean fever for > 15 years developed kidney failure because of secondary amyloidosis. He received livingunrelated-donor kidney transplant that functioned normally. He was on colchicine prophylaxis that was continued after transplant, and he received immunosuppression induction with antithymocyte globulin and maintenance with prednisolone, mycophenolate mofetil, and cyclosporine. After 2 months, he presented with severe myopathy and elevated creatine kinase. Muscle biopsy showed evidence of drug-induced toxic myopathy, most likely caused by cyclosporine in combination with colchicine. Cyclosporine was replaced with sirolimus and colchicine was stopped. Symptoms partially improved and creatine kinase decreased to normal. The prednisolone dosage was reduced gradually to 5 mg daily. At 8 months after transplant, he was readmitted because of severe arthralgia, prolonged fever, pleuritic chest pain, diffuse abdominal pain, purpuric rash, macroscopic hematuria, proteinuria, and diarrhea. The C-reactive protein and erythrocyte sedimentation rate were elevated. The clinical diagnosis was recurrent familial Mediterranean fever presenting as protracted febrile myalgia syndrome. Despite the history of toxic myopathy, he was restarted on colchicine (0.5 mg, twice daily), and colchicine was well tolerated. There was marked improvement of most symptoms within several days. Follow-up 5 years later showed normal kidney graft function and no familial Mediterranean fever activity on colchicine prophylaxis. In summary, familial Mediterranean fever reactivation and protracted febrile myalgia syndrome after kidney transplant may be treated with colchicine and modulation of immunosuppressive therapy.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Untitled

Halim¹,

Al-Otaibi²,

Donia³

et al. 2015

Exp Clin Transplant

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“…26 -27 After reviewing the literatures; all reported cases of adolesecence and adult PFM and our case are summarized in Table 2. [13,18,[21][22][23][28][29][30][31][32][33] Up to that time we found 13 cases of FMF developed PFM. Their age range 12-44yrs with mean age 28±16.…”

Section: Polyarteritis Nodosa(pan)mentioning

confidence: 99%

Protracted febrile myalgia syndrome in patient with familial mediterranean fever

Menyawi¹,

Essam²,

Shaker³

et al. 2018

MOJCR

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Familial Mediterranean fever (FMF) is a one of genetically basis auto inflammatory disease characterized by recurrent episodes of fever, serositis & musculoskeletal involvement. Protracted febrile myalgia syndrome (PFMS) is characterized by severe paralyzing myalgia, high fever, abdominal pain, diarrhea, arthritis/arthralgia, and transient vasculitic rashes. We report a 15year-old girl with PFM as non classical presenting symptoms of FMF, and discuss the course of management of this case.We reviewed the literature and mostly recorded all case reports of PFM affected adolesecent and adult patients over the past years to give special prominence to muscle affection in FMF particularly PFM Citation: Menyawi ME, Essam M, Shaker A, et al. Protracted febrile myalgia syndrome in patient with familial mediterranean fever.

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“…An inflammation of the testicular tunica vaginalis may also occur [6]. Muscular and skeletal involvement is frequent, often as recurrent simple myalgia or arthralgia, while approximately 30% of FMF patients complain of arthritides, especially affecting large joints, which are rarely erosive but may even persist for several days after fever resolution [7, 8]. More than 60% of patients have a disease onset before age 10 and 98% before age 30 [9, 10].…”

Section: Hereditary Periodic Fever Syndromesmentioning

confidence: 99%

Untangling the Web of Systemic Autoinflammatory Diseases

Rigante

Lopalco

Vitale

et al. 2014

Mediators of Inflammation

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The innate immune system is involved in the pathophysiology of systemic autoinflammatory diseases (SAIDs), an enlarging group of disorders caused by dysregulated production of proinflammatory cytokines, such as interleukin-1β and tumor necrosis factor-α, in which autoreactive T-lymphocytes and autoantibodies are indeed absent. A widely deranged innate immunity leads to overactivity of proinflammatory cytokines and subsequent multisite inflammatory symptoms depicting various conditions, such as hereditary periodic fevers, granulomatous disorders, and pyogenic diseases, collectively described in this review. Further research should enhance our understanding of the genetics behind SAIDs, unearth triggers of inflammatory attacks, and result in improvement for their diagnosis and treatment.

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Protracted febrile myalgia syndrome in familial Mediterranean fever

Cited by 8 publications

References 14 publications

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Protracted febrile myalgia syndrome in patient with familial mediterranean fever

Untangling the Web of Systemic Autoinflammatory Diseases

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