Protracted fatigue and debility after acute Q fever

Ayres, Jonathan Geoffrey; Smith, E.G.; Flint, Nicole C.

doi:10.1016/s0140-6736(96)91470-1

Cited by 53 publications

(42 citation statements)

References 4 publications

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“…Furthermore, C. burnetii infection appeared to be closely related to various subjective symptoms seen in these patients. The symptoms of post-QFS have been reported to overlap, to varying degrees, with those of CFS (1,2). Although the EB virus has previously been suggested to be involved in the development of CFS (13,14), we found no relationship between EB virus infection and the subjective symptoms observed in the current series.…”

Section: Discussioncontrasting

confidence: 84%

“…Marmion et al and Ayres et al reported post-Q fever fatigue syndrome (post-QFS) classified as one of the manifestation of chronic Q fever, following an acute infection with rickettsia Coxiella burnetii (C. burnetii), to resemble chronic fatigue syndrome (CFS) (1)(2)(3). These patients had longlasting symptoms including fatigue, myalgia, arthralgia, increased sweating, sleep disturbance, mood swings, and headache.…”

Section: Introductionmentioning

confidence: 99%

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Improvement of Chronic Nonspecific Symptoms by Long-term Minocycline Treatment in Japanese Patients with Coxiella burnetii Infection Considered to Have Post-Q Fever Fatigue Syndrome

et al. 2004

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Objective To address the presence of post-Q fever fatigue syndrome (post-QFS) in Japan, and to evaluate the efficacy of minocycline for this condition.Patients and Methods In 20 Coxiella burnetii (C. burnetii) seropositive patients with persistent nonspecific symptoms including general fatigue, low-grade fever, myalgia and arthralgia, changes in subjective symptoms, C. burnetii antibody titers and C. burnetii DNA were evaluated after antibiotic treatment.Results After treatment mainly with minocycline (100 mg/day for 3 months), the clinical picture improved in all 20 patients as evidenced by decreases in body temperature (

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Section: Discussioncontrasting

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Improvement of Chronic Nonspecific Symptoms by Long-term Minocycline Treatment in Japanese Patients with Coxiella burnetii Infection Considered to Have Post-Q Fever Fatigue Syndrome

et al. 2004

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“…Post-Q fever fatigue syndrome (QFS) presents with various nonspecific symptoms, including general fatigue, headache, arthralgia and myalgia, due to prolonged Coxiella burnetii (C. burnetii) infection, and have been classified as one of the manifestations of chronic Q fever by Marmion et al (1)(2)(3). We first reported that there are also patients with QFS, apparently due to C. burnetii infection, in Japan (4).…”

Section: Introductionmentioning

confidence: 99%

Treatment of Chronic Fatigue Syndrome with Antibiotics: Pilot Study Assessing the Involvement of Coxiella burnetii Infection

et al. 2005

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Objective To examine whether Coxiella burnetii (C. burnetii) is involved in chronic fatigue syndrome (CFS), we administered tetracycline antibiotics to subjects with CFS, and followed changes in clinical symptoms, PCR findings, and C. burnetii antibody titers.Patients and Methods The subjects were 8 patients with CFS and 213 with nonspecific complaints such as chronic fatigue and low-grade fever for several months or longer but not meeting the diagnostic criteria for CFS. All were examined for C. burnetii infection by nested PCR and the indirect immunofluorescence test (IF).Results Four CFS patients (the CFS group) and 54 controls [the post-Q fever fatigue syndrome (QFS) group] positive for C. burnetii were treated mainly with minocycline or doxycycline (100 mg/day) for 3 months. After treatment, all 58 patients tested negative for C. burnetii infection. In the CFS group, no significant difference was noted between the mean pre-and post-treatment temperatures or headache scores. Similarly, there was no significant improvement in performance status (PS) scores. In the QFS group, however, mean temperatures and headache scores were significantly decreased after treatment (p<0.001). PS scores were also improved.Conclusion These results suggest the possibility of direct involvement of C. burnetii in the pathological state of CFS to be low, despite the C. burnetii infection rate being high in CFS patients. This is a pilot study and further larger investigations are necessary to confirm our preliminary results.

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“…The death rate among persons with Q fever pneumonia is 0.5% to 1.5% (14). Up to half of patients may suffer protracted fatigue and weakness after acute disease (20,21). Rarely, more serious forms of chronic disease (most commonly endocarditis but also chronic hepatitis and vascular, osteoarticular, or pulmonary infections) may develop months to years after the acute infection (13,22,23).…”

mentioning

confidence: 99%