Protracted debility and fatigue after acute Q fever

Marmion, B. P.; Shannon, Michael P.; Maddocks, Ian; Storm, P.A.; Penttila, I A

doi:10.1016/s0140-6736(96)91469-5

Cited by 118 publications

(93 citation statements)

References 3 publications

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“…Post-Q fever fatigue syndrome (QFS) presents with various nonspecific symptoms, including general fatigue, headache, arthralgia and myalgia, due to prolonged Coxiella burnetii (C. burnetii) infection, and have been classified as one of the manifestations of chronic Q fever by Marmion et al (1)(2)(3). We first reported that there are also patients with QFS, apparently due to C. burnetii infection, in Japan (4).…”

Section: Introductionmentioning

confidence: 99%

Treatment of Chronic Fatigue Syndrome with Antibiotics: Pilot Study Assessing the Involvement of Coxiella burnetii Infection

et al. 2005

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Objective To examine whether Coxiella burnetii (C. burnetii) is involved in chronic fatigue syndrome (CFS), we administered tetracycline antibiotics to subjects with CFS, and followed changes in clinical symptoms, PCR findings, and C. burnetii antibody titers.Patients and Methods The subjects were 8 patients with CFS and 213 with nonspecific complaints such as chronic fatigue and low-grade fever for several months or longer but not meeting the diagnostic criteria for CFS. All were examined for C. burnetii infection by nested PCR and the indirect immunofluorescence test (IF).Results Four CFS patients (the CFS group) and 54 controls [the post-Q fever fatigue syndrome (QFS) group] positive for C. burnetii were treated mainly with minocycline or doxycycline (100 mg/day) for 3 months. After treatment, all 58 patients tested negative for C. burnetii infection. In the CFS group, no significant difference was noted between the mean pre-and post-treatment temperatures or headache scores. Similarly, there was no significant improvement in performance status (PS) scores. In the QFS group, however, mean temperatures and headache scores were significantly decreased after treatment (p<0.001). PS scores were also improved.Conclusion These results suggest the possibility of direct involvement of C. burnetii in the pathological state of CFS to be low, despite the C. burnetii infection rate being high in CFS patients. This is a pilot study and further larger investigations are necessary to confirm our preliminary results.

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Section: Introductionmentioning

confidence: 99%

Treatment of Chronic Fatigue Syndrome with Antibiotics: Pilot Study Assessing the Involvement of Coxiella burnetii Infection

et al. 2005

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“…Chronic Q fever often presents as endocarditis (14) and/or hepatitis and has been diagnosed occasionally in osteomyelitis cases (36,41). An association has also been made between a chronic fatiguelike syndrome and Q fever (27,40,58,60).…”

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confidence: 97%

Clinical and Pathologic Changes in a Guinea Pig Aerosol Challenge Model of Acute Q Fever

et al. 2006

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Acute Q fever is a zoonotic disease caused by the obligate intracellular bacterium Coxiella burnetii and can manifest as a flu-like illness, pneumonia, or hepatitis. A need exists in Q fever research for animal models mimicking both the typical route of infection (inhalation) and the clinical illness seen in human cases of Q fever. A guinea pig aerosol challenge model was developed using C. burnetii Nine Mile phase I (RSA 493), administered using a specialized chamber designed to deliver droplet nuclei directly to the alveolar spaces. Guinea pigs were given 10 1 to 10 6 organisms and evaluated for 28 days postinfection. Clinical signs included fever, weight loss, respiratory difficulty, and death, with the degree and duration of response corresponding to the dose of organism delivered. Histopathologic evaluation of the lungs of animals infected with a high dose showed coalescing panleukocytic bronchointerstitial pneumonia at 7 days postinfection that resolved to multifocal lymphohistiocytic interstitial pneumonia by 28 days. Guinea pigs receiving a killed whole-cell vaccine prior to challenge with the highest dose of C. burnetii were protected against lethal infection and did not develop fever. Clinical signs and pathological changes noted for these guinea pigs were comparable to those seen in human acute Q fever, making this an accurate and valuable animal model of human disease.

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“…1,3,[4][5][6] QFS can last for years and is highly incapacitating. [7][8][9][10] The symptoms of severe QFS include profound fatigue, myalgia, arthralgia, nausea, persistent headache, profuse night sweats, muscle fasciculation, blurred vision, ethanol intolerance, lymph node pain, irritability, depression, poor concentration and disturbed sleep. 7 Mortality due to Q fever is reported to be between 0.5% and 2.4%.…”

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confidence: 99%

An economic evaluation of increased uptake in Q fever vaccination among meat and agricultural industry workers following implementation of the National Q Fever Management Program

Kermode

Yong²,

Hurley

et al. 2003

Australian and New Zealand Journal of Public Health

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Protracted debility and fatigue after acute Q fever

Cited by 118 publications

References 3 publications

Treatment of Chronic Fatigue Syndrome with Antibiotics: Pilot Study Assessing the Involvement of Coxiella burnetii Infection

Treatment of Chronic Fatigue Syndrome with Antibiotics: Pilot Study Assessing the Involvement of Coxiella burnetii Infection

Clinical and Pathologic Changes in a Guinea Pig Aerosol Challenge Model of Acute Q Fever

An economic evaluation of increased uptake in Q fever vaccination among meat and agricultural industry workers following implementation of the National Q Fever Management Program

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