Protracted Bacterial Bronchitis in Children

Wurzel, Danielle; Marchant, Julie M.; Yerkovich, Stephanie T.; Upham, John W.; Petsky, Helen; Smith‐Vaughan, Heidi; Masters, Brent; Buntain, Helen; Chang, Anne B.

doi:10.1016/j.chest.2016.06.030

Cited by 112 publications

(47 citation statements)

References 36 publications

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“…For example, we examined presence of H. influenzae as our earlier cohort study of children with PBB enrolled at the time of bronchoscopy identified that culturing H. influenzae in BAL fluid was a significant independent predictor (OR adj , 7.6; 95% CI, 1.7-34.3; P = .009) of being diagnosed with bronchiectasis within the next 2 years. 33 However, the absence of statistical significance may be related to our relatively small sample size. Also, BAL neutrophil counts may not be sensitive enough (compared to other downstream markers like IL-1β) to differentiate the degree of airway neutrophilia between subjects.…”

Section: Discussionmentioning

confidence: 87%

“…We chose these factors based on biological plausibility and/or published data. For example, we examined presence of H. influenzae as our earlier cohort study of children with PBB enrolled at the time of bronchoscopy identified that culturing H. influenzae in BAL fluid was a significant independent predictor (OR adj , 7.6; 95% CI, 1.7‐34.3; P = .009) of being diagnosed with bronchiectasis within the next 2 years . However, the absence of statistical significance may be related to our relatively small sample size.…”

Section: Discussionmentioning

confidence: 98%

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Predictors of time to cough resolution in children with chronic wet cough treated with antibiotics after bronchoscopy

Wong

Marchant

Yerkovich

et al. 2019

Pediatric Pulmonology

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Background Chronic wet cough is common in pediatric pulmonology practice and is clinically important. Guidelines recommend treatment with antibiotics as their effectiveness has been proven. However, factors associated with duration of cough in response to antibiotics in children with chronic wet cough have not been prospectively examined. Objective To determine if demographic, clinical and/or bronchoalveolar lavage (BAL) factors are associated with “time to cough resolution” in children with chronic wet cough treated with antibiotics after bronchoscopy. Methods Data from children with chronic wet cough treated with antibiotics after bronchoscopy were extracted from a prospective cohort study database. Cough dairies were used to determine when the cough resolved. Associations between various factors with “time to cough resolution” were examined using regression. Results The median age of the 133 children was 2.4 years (interquartile range, 1.4‐4.9). Duration of prior cough at bronchoscopy was significantly positively related with “time to cough resolution” (β = .010; 95% confidence interval, 0.004‐0.017; P = .002). This translated to; for each month of prior cough, it took an extra 1.02 days to achieve cough resolution while on antibiotic treatment. Gender, age, diagnosis, tobacco smoke exposure, pneumonia history, blood cellularity, and BAL cellular and microbiology profiles were not significantly associated with time to cough resolution. Conclusion In children with chronic wet cough, duration of cough before antibiotic treatment is a small but significant determinant of “time to cough resolution.” Research using standardized antibiotic regimes is required to provide clinical and/or biomarkers that can further identify factors associated with the response of chronic cough to antibiotic treatment.

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Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 98%

Predictors of time to cough resolution in children with chronic wet cough treated with antibiotics after bronchoscopy

Wong

Marchant

Yerkovich

et al. 2019

Pediatric Pulmonology

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“…These endotypes are clinically relevant as those with PBB-extended are more likely to have tracheo-bronchomalacia [34] and those with recurrent PBB are more likely to have subsequent diagnosis of bronchiectasis. [35]…”

Section: Diagnosismentioning

confidence: 99%

An approach to the child with a wet cough

Gilchrist

2019

Paediatric Respiratory Reviews

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“…This may be associated with bronchiectasis in a subgroup of children with Haemophilus influenzae infection or recurrent episodes,12 and these children require particular attention. Persistent moist cough is a hallmark of bronchiectasis, and can be either idiopathic or due to disorders such as immunodeficiency, aspiration syndromes, cystic fibrosis, or primary ciliary dyskinesia 13…”

Section: What Underlying Causes Should I Consider?mentioning

confidence: 99%