Prototype design of readout electronics for In-Beam TOF-PET of Heavy-Ion Cancer Therapy Device

Yan, Junwei; Yang, Hsiharng; Ke, Linghong; Niu, Xiaxia; Chen, J.D.; Zhang, X.L.; Su, Hong; Kong, Jie

doi:10.1016/j.nima.2020.163492

Cited by 8 publications

(6 citation statements)

References 15 publications

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“…In the last few years, our efforts have been devoted to the investigation of the acquisition system of the ibPET. Based on previous experiences with the prototype readout electronics [9], we recently upgraded with a new DAQ system, with real-time signal processing, system calibration, and correction method. Preliminary results with the ibPET system showed that the readout electronics have a higher count rate and that the performance meets the online real-time monitoring requirement [10,11].…”

Section: Jinst 19 P04021mentioning

confidence: 99%

“…A new modular dual-head in-beam PET imaging system was arranged on the beam line at the HIMM heavy ion therapy facility (Wuwei, Ganshu, China) as in previous experiments. In comparison to the previous system [9], the number of detector blocks per modular head was increased from 4 to 8, so that its active area is increased two-fold, i.e., from 10.4 cm × 10.4 cm to 20.8 cm × 10.4 cm. Each detector block is realized assembling 22 × 22 LYSO [13] pixel elements (2 mm × 2 mm × 15 mm) coupled to a Hamamatsu H8500C [14] PMT already described in [9,10], as shown in figure 2(a).…”

Section: The Ibpet Systemmentioning

confidence: 99%

“…In comparison to the previous system [9], the number of detector blocks per modular head was increased from 4 to 8, so that its active area is increased two-fold, i.e., from 10.4 cm × 10.4 cm to 20.8 cm × 10.4 cm. Each detector block is realized assembling 22 × 22 LYSO [13] pixel elements (2 mm × 2 mm × 15 mm) coupled to a Hamamatsu H8500C [14] PMT already described in [9,10], as shown in figure 2(a). The two opposing heads distance in this work was 50 cm, and the geometrical acceptance was 208 mm along the axial (z) direction.…”

Section: The Ibpet Systemmentioning

confidence: 99%

“…The method for estimating the ion range and dose distribution is to monitor the distribution of positron activity produced by nuclear reactions from incident heavy ions [7]. Therefore, a treatment monitoring system [8,9] is required. One of the main actions that are being taken by the IMP-CSA is developing a dedicated and real-time in-beam PET imaging system, called heavy-ion in-beam PET (ibPET), those that can be mounted directly on the beam line, allowing the acquisition of data during and immediately after irradiation.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

A dedicated in-beam PET system with a modular dual-head for radiotherapy imaging in HIMM

Kong,

Zhou,

Wang

et al. 2024

J. Inst.

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This paper presents a heavy-ion in-beam PET, referred to as ibPET with a specifically custom designed data acquisition system, which was constructed and tested at the Heavy Ion Medical Machine (HIMM) beam-line, HICTC in Wuwei. The data acquisition system of ibPET has undergone several upgrades during the years, And its data processing capability now exceeds one million events per second per channel. To achieve optimal performance of the ibPET under existing conditions, we tested coincident events and noise equivalent count (NEC) under different time coincidence windows.The results show that the signal-to-noise ratio of the reconstructed image data reaches its peak when the time window is around 3 ns, indicating that the ibPET performance is optimal at this point. In order to determine the size of the time window, we measured the system's time resolution FWHM to be 1.63 ns, and ultimately chose a time window size of twice the time resolution FWHM, which is 3.25 ns. Meanwhile, we demonstrate the capability of our ibPET to monitor the dose range with various irradiation. The results demonstrate that the system exhibits the expected exponential decay in counting rate after irradiation, and accurately provides penetration depth positions at different energy levels.

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Section: Jinst 19 P04021mentioning

confidence: 99%

Section: The Ibpet Systemmentioning

confidence: 99%

Section: The Ibpet Systemmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A dedicated in-beam PET system with a modular dual-head for radiotherapy imaging in HIMM

Kong,

Zhou,

Wang

et al. 2024

J. Inst.

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“…There are two commonly used charge measurement methods in PET electronics, namely direct digitization through an ADC chip [15] with digital peak detection or integration, and time-overthreshold (TOT) with TDC digitization [16]. Several FPGA-based measurement methods have also been proposed on the basis of these two methods [24,28,29].…”

Section: Introductionmentioning

confidence: 99%

Prototype of a digitizer module based on multicycle-encoding FPGA ADC for a small animal PET

et al. 2023

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Current research in small animal positron emission tomography (PET) scanners focus on obtaining better spatial resolution and higher sensitivity. These enhancements of scanner performance result in a corresponding increase in the complexity of the electronics, which usually manifests through an increase in the number of electronics channels. Analog-to-digital converters (ADCs) implemented in field programmable gate arrays (FPGAs) are an effective way to simplify electronics complexity. In this paper, a resource-saving multicycle-encoding structure of an FPGA-based ADC with automated calibration is proposed, which achieves a sampling rate of 250 Msps. A digitizer module prototype containing 64 charge measurement channels based on the FPGA ADC is designed using a Kintex-7 FPGA. The effective number of bits (ENOB) achieved using the FPGA ADC is 4.26 bits under a 10.0555 MHz sine wave input. The charge measurement resolution of each channel is better than 5‰ full width half maximum under a 0.8 V signal input and 3% under inputs in the range 0.1 V to 1.2 V. The integral nonlinearity of each channel is within ± 1%.

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A real-time sorting algorithm for in-beam PET of heavy-ion cancer therapy device

Yan

Chen

et al. 2021

Nuclear Engineering and Technology

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Prototype design of readout electronics for In-Beam TOF-PET of Heavy-Ion Cancer Therapy Device

Cited by 8 publications

References 15 publications

A dedicated in-beam PET system with a modular dual-head for radiotherapy imaging in HIMM

A dedicated in-beam PET system with a modular dual-head for radiotherapy imaging in HIMM

Prototype of a digitizer module based on multicycle-encoding FPGA ADC for a small animal PET

A real-time sorting algorithm for in-beam PET of heavy-ion cancer therapy device

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