Protoplasmic Action of Copper and Gold

Voegtlin, Carl; Johnson, John M.; Dyer, Helen A.

doi:10.1073/pnas.11.6.344

Cited by 21 publications

(1 citation statement)

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“…By work in this laboratory and that of other investigators, it has been shown that the suprarenal glands are essential in the mechanism of natural resistance (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12). In the case of suprarenalectomized rats, this resistance can be raised almost to normal by injection of the hormone of the suprarenal cortex (13)(14)(15).…”

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The Effect of Bilateral Suprarenalectomy in Adult Albino Rats on the Natural and Acquired Resistance to Bartonella Muris Anemia

Marmorston-Gottesman¹,

Perla²

1932

Journal of Experimental Medicine

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By work in this laboratory and that of other investigators, it has been shown that the suprarenal glands are essential in the mechanism of natural resistance (1-12). In the case of suprarenalectomized rats, this resistance can be raised almost to normal by injection of the hormone of the suprarenal cortex (13)(14)(15). In the present communication further data are presented on the effect of bilateral suprarenalectomy in the rat on natural and acquired resistance to BartoneUa muris anemia. The Effect of Bilateral Suprarenalectomy on the Acquired Resistance to Bartonella muris AnemiaThe rat is spontaneously infected with Bartonella muris between the 4th and 5th week of life (16). It becomes a carrier and acquires immunity to the infection (17). The spontaneous recurrence of infection following splenectomy with the development of anemia in the adult rat of carrier stock is indicative of a depression in the acquired resistance to Bartonella muris. 1The rats used in this experiment were bred and raised in our laboratory and were carriers of Bartonella muris. Ten albino rats of approximately 3 months of age were suprarenalectomized. On the 6th day after suprarenalectomy each of these was injected intraperitoneally with 2 co. of whole blood of anemic adult splenectomized rats, drawn at the height of infection. The red cell count and the percentage of hemoglobin were determined and blood smears examined daily.

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