Protons Differentially Activate TDAG8 Homologs from Various Species

Musha, Shiori; Nagayama, Suminori; Murakami, Syo; Kojima, Ryotaro; Deai, Masahito; Sato, Kōichi; Okajima, Fumikazu; Ueharu, Hiroki; Tomura, Hideaki

doi:10.2108/zs180128

Cited by 2 publications

(1 citation statement)

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“…However, while GPR68 cloned from D. rerio , X. laevis , G. gallus , M. musculus , R. norvegicus and H. sapiens have all been shown to respond to protons [202], the proton sensitivity of GPR65 is not conserved across phyla. Homo sapiens , M. musculus as well as X. laevis GPR65 all respond to extracellular acidification while the G. gallus and D. rerio homologues do not [203]. It is thus apparent that the selective pressure for individual receptors to respond to protons is not as strong as that for expression of PS-GPCRs in general.…”

Section: Proton-sensing G Protein-coupled Receptorsmentioning

confidence: 99%

Evolution of acid nociception: ion channels and receptors for detecting acid

Pattison

Callejo

Smith

2019

Phil. Trans. R. Soc. B

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Nociceptors, i.e. sensory neurons tuned to detect noxious stimuli, are found in numerous phyla of the Animalia kingdom and are often polymodal, responding to a variety of stimuli, e.g. heat, cold, pressure and chemicals, such as acid. Owing to the ability of protons to have a profound effect on ionic homeostasis and damage macromolecular structures, it is no wonder that the ability to detect acid is conserved across many species. To detect changes in pH, nociceptors are equipped with an assortment of different acid sensors, some of which can detect mild changes in pH, such as the acid-sensing ion channels, proton-sensing G protein-coupled receptors and several two-pore potassium channels, whereas others, such as the transient receptor potential vanilloid 1 ion channel, require larger shifts in pH. This review will discuss the evolution of acid sensation and the different mechanisms by which nociceptors can detect acid. This article is part of the Theo Murphy meeting issue ‘Evolution of mechanisms and behaviour important for pain’.

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Section: Proton-sensing G Protein-coupled Receptorsmentioning

confidence: 99%