Proton vs carbon ion beams in the definitive radiation treatment of cancer patients

Suit, Herman D.; DeLaney, Thomas F.; Goldberg, S. Nahum; Paganetti, Harald; Clasie, B; Gerweck, Leo E.; Niemierko, Andrzej; Hall, Eric J.; Flanz, J.; Hallman, Josh; Trofimov, Alexei V.

doi:10.1016/j.radonc.2010.01.015

Cited by 230 publications

(202 citation statements)

References 117 publications

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“…As in proton radiotherapy, the depth-dose profile (Bragg peak) of carbon ions allows for highly conformal irradiations of the tumor. However, the rise of the relative biological effectiveness (RBE) with penetration depth towards the distal end of a spreadout Bragg peak (SOBP) is much more pronounced for carbon ions than for protons [5]. Quantitatively, the RBE is given by the ratio of a photon and an isoeffective carbon ion dose at a defined endpoint.…”

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confidence: 99%

The relative biological effectiveness of carbon ion irradiations of the rat spinal cord increases linearly with LET up to 99 keV/μm

et al. 2016

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confidence: 99%

The relative biological effectiveness of carbon ion irradiations of the rat spinal cord increases linearly with LET up to 99 keV/μm

et al. 2016

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“…The previous accumulation of fast neutron in vitro and in vivo data in the UK (between 1970 and 1990) serves as a good example because publications continue to be based on these results and are being extrapolated to proton therapy, with RBE values similar to carbon ion therapy [6]; although a carbon ion data set is being collated in Germany, it could and should be extended. Much more could be done with specific experiments using a more focused approach, which would complement the already important work emerging from carbon ion facilities [1,2,5], including verification of microdosimetry-based RBE predictions in a wider range of biological end points.…”

Section: Discussionmentioning

confidence: 99%

“…Several speakers emphasised that, although protons and carbon ions are in clinical use, there is limited clinical evidence as to their relative superiority [2]. Radiobiological studies suggest a potential for improved treatment of intrinsically radioresistant and hypoxic tumours in the case of carbon ions owing to the increased ionisation density.…”

Section: Present Issues In Particle Therapymentioning

confidence: 99%

“…There is a real need to study the various phenomena in a more systematic way by using a dedicated facility with standardisation of experimental conditions and biological end points. Present clinical practice would probably benefit considerably from further studies to provide better predictive information [2,3,6].…”

Section: Justification and Aims Of Radiobiological Studiesmentioning

confidence: 99%

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A possible biomedical facility at the European Organization for Nuclear Research (CERN)

Dosanjh

Jones²,

Myers³

2013

BJR

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A well-attended meeting, called "Brainstorming discussion for a possible biomedical facility at CERN", was held by the European Organization for Nuclear Research (CERN) at the European Laboratory for Particle Physics on 25 June 2012. This was concerned with adapting an existing, but little used, 78-m circumference CERN synchrotron to deliver a wide range of ion species, preferably from protons to at least neon ions, with beam specifications that match existing clinical facilities. The potential extensive research portfolio discussed included beam ballistics in humanoid phantoms, advanced dosimetry, remote imaging techniques and technical developments in beam delivery, including gantry design. In addition, a modern laboratory for biomedical characterisation of these beams would allow important radiobiological studies, such as relative biological effectiveness, in a dedicated facility with standardisation of experimental conditions and biological end points. A control photon and electron beam would be required nearby for relative biological effectiveness comparisons. Research beam time availability would far exceed that at other facilities throughout the world. This would allow more rapid progress in several biomedical areas, such as in charged hadron therapy of cancer, radioisotope production and radioprotection. The ethos of CERN, in terms of open access, peer-reviewed projects and governance has been so successful for High Energy Physics that application of the same to biomedicine would attract high-quality research, with possible contributions from Europe and beyond, along with potential new funding streams.

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“…Over the past 30 years, ion beam radiotherapy using particles like proton, helium, carbon ions has been gradually and slowly increasingly in popularity in radiation oncology [1][2][3].The inverted depth dose profile ⎯the increase of dose along the penetration depth (the Bragg Peak) and a sharp drop after the Bragg Peak ⎯ make ion beams an ideal tool for treatment of the deepseated tumours [1][2][3][4][5][6][7]. For carbon ions, the excellent dose profile is further boosted by an additional increase in the relative biological effectiveness (RBE) along the depth till the end of the particle range [2-4, 6, 8].Because of the distinguished physical and biological properties, carbon ion radiotherapy (CIRT) has become a unique research focus around the world.…”

Section: Introductionmentioning

confidence: 99%

A preliminary Monte Carlo study for the treatment head of a carbon-ion radiotherapy facility using TOPAS

et al. 2017

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Abstract. In medical physics it is desirable to have a Monte Carlo code that is less complex, reliable yet flexible for dose verification, optimization, and component design. TOPAS is a newly developed Monte Carlo simulation tool which combines extensive radiation physics libraries available in Geant4 code, easyto-use geometry and support for visualization. Although TOPAS has been widely tested and verified in simulations of proton therapy, there has been no reported application for carbon ion therapy. To evaluate the feasibility and accuracy of TOPAS simulations for carbon ion therapy, a licensed TOPAS code (version 3_0_p1) was used to carry out a dosimetric study of therapeutic carbon ions. Results of depth dose profile based on different physics models have been obtained and compared with the measurements. It is found that the G4QMD model is at least as accurate as the TOPAS default BIC physics model for carbon ions, but when the energy is increased to relatively high levels such as 400 MeV/u, the G4QMD model shows preferable performance. Also, simulations of special components used in the treatment head at the Institute of Modern Physics facility was conducted to investigate the Spread-Out dose distribution in water. The physical dose in water of SOBP was found to be consistent with the aim of the 6 cm ridge filter.

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Proton vs carbon ion beams in the definitive radiation treatment of cancer patients

Cited by 230 publications

References 117 publications

The relative biological effectiveness of carbon ion irradiations of the rat spinal cord increases linearly with LET up to 99 keV/μm

The relative biological effectiveness of carbon ion irradiations of the rat spinal cord increases linearly with LET up to 99 keV/μm

A possible biomedical facility at the European Organization for Nuclear Research (CERN)

A preliminary Monte Carlo study for the treatment head of a carbon-ion radiotherapy facility using TOPAS

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