Proton therapy for head and neck squamous cell carcinomas: A review of the physical and clinical challenges

Beddok, Arnaud; Véla, A.; Calugaru, Valentin; Tessonnier, Thomas; Kubeš, Jiří; Dutheil, Pauline; Gérard, A.; Vidal, M.; Goudjil, F.; Florescu, C.; Kammerer, Emmanuel; Bénézery, Karen; Hérault, J.; Poortmans, P.; Bourhis, Jean; Thariat, Juliette

doi:10.1016/j.radonc.2020.03.006

Cited by 42 publications

(36 citation statements)

References 84 publications

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“…However, Christianen et al reported that the reduction of normal tissue complication probability for grade >2 late dysphagia at 6 months after RT was only 4.9% with swallowing sparing IMRT compared to standard parotid sparing IMRT [7]. Intensitymodulated proton therapy (IMPT) may have a potential advantage in reducing side effects compared to IMRT and VMAT [27][28][29]. However, with regard to late dysphagia, IMPT may have more benefits in the upper head and neck cancers like oropharyngeal cancer [27].…”

Section: Discussionmentioning

confidence: 99%

Death unrelated to cancer and death from aspiration pneumonia after definitive radiotherapy for head and neck cancer

Kanayama

Otozai²,

Yoshii³

et al. 2020

Radiotherapy and Oncology

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Background and purpose: The incidence of hypopharyngeal and supraglottic cancer (HSC) is high in Japan. This study aimed to retrospectively identify risk factors for death unrelated to cancer and death from aspiration pneumonia after definitive radiotherapy (RT) for HSC. Materials and methods: Overall, 391 patients who began definitive RT for HSC between 2006 and 2014 were identified from the Osaka International Cancer Institute electronic database. Among 391 patients, 33 had a history of surgery for esophageal cancer (EC) and 19 received simultaneous RT for synchronous EC. The cause of death was divided into 3 main categories: ''cancer under study," ''other malignancy," and ''unrelated to cancer." Cox proportional hazard model was used to estimate the hazard ratio (HR). Results: The median follow-up for survivors was 8 (range 3.6-14.1) years. At the last follow-up, 202 patients died. Death from ''cancer under study," ''other malignancy," and ''unrelated to cancer" occurred in 92 (45.5%), 55 (27.2%), and 55 (27.2%) patients, respectively. Twelve patients died from aspiration pneumonia. In multivariate analysis for death unrelated to cancer and death from aspiration pneumonia, history of surgery for EC (HR: 3.87, p < 0.001; HR: 6.84, p = 0.007, respectively) and simultaneous RT for synchronous EC (HR: 3.74, p = 0.006; HR: 16.37, p < 0.001, respectively) were significant risk factors. Conclusion: The laryngeal preservation approach by RT for HSC patients with a history of surgery for EC and simultaneous RT for synchronous EC should be used with caution.

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Section: Discussionmentioning

confidence: 99%

Death unrelated to cancer and death from aspiration pneumonia after definitive radiotherapy for head and neck cancer

Kanayama

Otozai²,

Yoshii³

et al. 2020

Radiotherapy and Oncology

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“…It considerably worsens patients' quality of life, increases the risk for malnutrition and infection and can therefore result in treatment interruptions that may in turn deteriorate oncological outcomes. The incidence of severe mucositis after proton irradiation for head-and-neck squamous cell carcinomas ranges between 40 and 79% (30). The impact of both bone marrow-and adipose tissue-derived MSCs on radiation-induced mucositis has been examined in several preclinical studies (19,(31)(32)(33).…”

Section: Head-and-neck Tumorsmentioning

confidence: 99%

The Particle Radiobiology of Multipotent Mesenchymal Stromal Cells: A Key to Mitigating Radiation-Induced Tissue Toxicities in Cancer Treatment and Beyond?

2021

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Mesenchymal stromal cells (MSCs) comprise a heterogeneous population of multipotent stromal cells that have gained attention for the treatment of irradiation-induced normal tissue toxicities due to their regenerative abilities. As the vast majority of studies focused on the effects of MSCs for photon irradiation-induced toxicities, little is known about the regenerative abilities of MSCs for particle irradiation-induced tissue damage or the effects of particle irradiation on the stem cell characteristics of MSCs themselves. MSC-based therapies may help treat particle irradiation-related tissue lesions in the context of cancer radiotherapy. As the number of clinical proton therapy centers is increasing, there is a need to decidedly investigate MSC-based treatments for particle irradiation-induced sequelae. Furthermore, therapies with MSCs or MSC-derived exosomes may also become a useful tool for manned space exploration or after radiation accidents and nuclear terrorism. However, such treatments require an in-depth knowledge about the effects of particle radiation on MSCs and the effects of MSCs on particle radiation-injured tissues. Here, the existing body of evidence regarding the particle radiobiology of MSCs as well as regarding MSC-based treatments for some typical particle irradiation-induced toxicities is presented and critically discussed.

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“…Given the complexity of IMPT planning, it is more resource demanding than VMAT planning [8]. In our clinic, an IMPT plan takes approximately 2.5 days from initiation of planning to the review and approval by the multidisciplinary team while this process takes approximately half a day for VMAT.…”

Section: Introductionmentioning

confidence: 99%

Development of advanced preselection tools to reduce redundant plan comparisons in model-based selection of head and neck cancer patients for proton therapy

Tambaş

Laan

Rutgers

et al. 2021

Radiotherapy and Oncology

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Proton therapy for head and neck squamous cell carcinomas: A review of the physical and clinical challenges

Cited by 42 publications

References 84 publications

Death unrelated to cancer and death from aspiration pneumonia after definitive radiotherapy for head and neck cancer

Death unrelated to cancer and death from aspiration pneumonia after definitive radiotherapy for head and neck cancer

The Particle Radiobiology of Multipotent Mesenchymal Stromal Cells: A Key to Mitigating Radiation-Induced Tissue Toxicities in Cancer Treatment and Beyond?

Development of advanced preselection tools to reduce redundant plan comparisons in model-based selection of head and neck cancer patients for proton therapy

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