2006
DOI: 10.1097/01.iio.0000195853.85581.c0
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Proton Teletherapy of Uveal Melanoma

Abstract: The optimal treatment of uveal melanoma would destroy the intraocular tumor, retain good vision, and avoid the development of metastatic disease. Unfortunately, inherent limitations make the development of such an optimal therapy unlikely in the near future. 1 One, approximately two thirds of choroidal melanomas examined in most ophthalmic oncologic practices are within 3 mm of the optic nerve or fovea. Even with a very focused type of treatment-delivery system, to avoid a marginal miss, usually such eyes have… Show more

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Cited by 14 publications
(7 citation statements)
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References 19 publications
(30 reference statements)
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“…Interestingly, their patient cohort was similar to the patients analyzed in the current study with mostly challenging-to-treat medium to large uveal melanomas (medium to large size, 97%) with worse prognoses. Most other proton series involve a higher number of small tumors that are more amenable to treatment [21,22]. Our eye retention rate was 86.7% at a mean time of 36 months and the disease-specific survival rate was 84.8% at 3 years and, therefore, almost identical to the McDonald series.…”
Section: Discussionsupporting
confidence: 55%
“…Interestingly, their patient cohort was similar to the patients analyzed in the current study with mostly challenging-to-treat medium to large uveal melanomas (medium to large size, 97%) with worse prognoses. Most other proton series involve a higher number of small tumors that are more amenable to treatment [21,22]. Our eye retention rate was 86.7% at a mean time of 36 months and the disease-specific survival rate was 84.8% at 3 years and, therefore, almost identical to the McDonald series.…”
Section: Discussionsupporting
confidence: 55%
“…With current techniques and appropriate patient selection a >98% local control rate can be expected. 24 On the other hand, long-term results of brachytherapy for intraocular melanomas suggest that this modality may provide equally satisfactory outcomes to particle therapy. 26 …”
Section: Uveal Melanomamentioning
confidence: 99%
“…23 Local control at 10 years was reported at 95.4.% and considered comparable to that achievable with protons. 24 A large retrospective analysis from the Paul Scherrer Institut (PSI) reported excellent eye-retention outcomes, with an overall rate of 83.7 at 15 years. 25 After optimization of the treatment technique the 5-year eye-retention rate was raised from 97.1% to 100% in small tumors, from 86.7% to 99.7% in medium, and from 71.1% to 89.5% in large tumors.…”
Section: Uveal Melanomamentioning
confidence: 99%
“…The goal of radiotherapy in treating uveal melanoma is to achieve tumor control and ocular preservation [1,7,8]. A variety of radiation devices have been used to reach this goal.…”
Section: Discussionmentioning
confidence: 99%