Proton relaxation times in human red bone marrow by volume selective magnetic resonance spectroscopy

Schick, Fritz; Bongers, H.; Jung, Wulf‐Ingo; Eismann, Beate; Skalej, Martin; Einsele, Hermann; Lutz, O.; Claussen, Claus D.

doi:10.1007/bf03166165

Cited by 28 publications

(30 citation statements)

References 16 publications

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“…12 Third, bone marrow is characterized by a large difference in T 1 relaxation times between water and fat compartments. 34 T 1 -bias effects [20][21][22] were presently minimized by using a small flip angle excitation. Our study had some limitations.…”

Section: 18mentioning

confidence: 99%

Assessment of whole spine vertebral bone marrow fat using chemical shift‐encoding based water‐fat MRI

Baum

Yap

Dieckmeyer

et al. 2015

Magnetic Resonance Imaging

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Section: 18mentioning

confidence: 99%

Assessment of whole spine vertebral bone marrow fat using chemical shift‐encoding based water‐fat MRI

Baum

Yap

Dieckmeyer

et al. 2015

Magnetic Resonance Imaging

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“…In addition, irregularly distributed subregions (mainly in the center of the vertebral bodies) were irreversibly impaired by former cytotoxic treatment (e.g., patient 2 and examples in the references [32,38]). …”

Section: Discussionmentioning

confidence: 99%

“…The volume elements for spectroscopy of bone marrow were positioned in the center of vertebral bodies of the lumbar spine (L-3), as in former studies [3,31,32], to ensure minimum contamination from outside the volume of interest (VOI).…”

Section: Volume-selective 1 H Spectroscopymentioning

confidence: 99%

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Assessment of the composition of bone marrow prior to and following autologous BMT and PBSCT by magnetic resonance

Schick

Einsele

Weiss

et al. 1996

Annals of Hematology

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Lumbar bone marrow was assessed by means of magnetic resonance (MR) in 23 examinations of eight patients who underwent autologous bone marrow transplantation (ABMT) or peripheral blood stem cell transplantation (PBSCT). Various imaging and spectroscopic techniques were applied for measurements carried out prior to conditioning for ABMT/PBSCT and in the course of reconstitution and correlated with clinical and blood chemistry data in these patients. The signal intensity from lumbar bone marrow was determined in T1-weighted and water- and fat-selective MR images. The distribution of the magnetic field was demonstrated by a field-mapping method. Localized proton spectroscopy was performed from volume elements of 2 ml located in the central region of vertebral bodies in order to evaluate the fraction of the water signals, the transverse relaxation times T2 of the signals from water and lipids, and the line widths of the spectral signals. Regions of bone marrow after inflammatory conditions or intensive irradiation are shown to be not involved in marrow reconstitution. Additional information about marrow composition was obtained by the magnetic field mapping and by the line widths in the spectra. Considerable alterations of the amount of paramagnetic hemosiderin were revealed following transplantation. Patients with low water signal and strong local inhomogeneities of the magnetic field in the marrow prior to transplantation had a delayed hematopoietic reconstitution compared with the patients lacking these MR features.

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“…Thirty-two acquisitions with a repetition time (TR) of 3 s were accumulated for each spectrum to achieve a good signal-to-noise ratio within a reasonable measuring time of 3 minutes. It should be mentioned that the TR of 3 s slightly reduces the water signal with its long TI relaxation time of about 1.0-1.3 s but does not reduce the lipid signals with a T, value of about 300 ms (30).…”

Section: Pulsed Magnetization Transfermentioning

confidence: 99%

Magnetization transfer in hemopoietic bone marrow examined by localized proton spectroscopy

Schick¹,

Forster²,

Einsele³

et al. 1995

Magnetic Resonance in Med

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The sensitivity of hemopoietic bone marrow to magnetization transfer is analyzed in 15 healthy volunteers and seven patients with different hematological disorders (inflammation, plasmacytoma, hemopoietic reconstitution after bone marrow transplantation). To obtain sufficient signal-to-noise ratio, a 90 degrees - 180 degrees - 180 degrees double spin echo (PRESS) single voxel spectroscopic method was combined with pulsed magnetization transfer. Several spectra were recorded from each volume element inside the vertebral marrow, alternately with and without prepulses for magnetization transfer. Water signals from marrow with increased content of extracellular water due to inflammation or edema revealed less magnetization transfer effects than marrow with increased intracellular water content due to high cellularity. The preliminary results show magnetization transfer to be a promising tool for the clinically important characterization of the water composition in red bone marrow.

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Proton relaxation times in human red bone marrow by volume selective magnetic resonance spectroscopy

Cited by 28 publications

References 16 publications

Assessment of whole spine vertebral bone marrow fat using chemical shift‐encoding based water‐fat MRI

Assessment of whole spine vertebral bone marrow fat using chemical shift‐encoding based water‐fat MRI

Assessment of the composition of bone marrow prior to and following autologous BMT and PBSCT by magnetic resonance

Magnetization transfer in hemopoietic bone marrow examined by localized proton spectroscopy

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