We evaluate the single event tolerance of the x-ray silicon-on-insulator (SOI) pixel sensor named XRPIX, developed for the future x-ray astronomical satellite FORCE. In this work, we measure the cross-section of single event upset (SEU) of the shift register on XRPIX by irradiating heavy ion beams with linear energy transfer (LET) ranging from 0.022 to 68 MeV∕ðmg∕cm 2 Þ. From the SEU cross-section curve, the saturation cross-section and threshold LET are successfully obtained to be 3.4 þ2.9 −0.9 × 10 −10 cm 2 ∕bit and 7.3 þ1.9 −3.5 MeV∕ðmg∕cm 2 Þ, respectively. Using these values, the SEU rate in orbit is estimated to be ≲0.1 event∕year primarily due to the secondary particles induced by cosmic-ray protons. This SEU rate of the shift register on XRPIX is negligible in the FORCE orbit.