Proton Pump Inhibitors Increase Incidence of Nonsteroidal Anti-Inflammatory Drug–Induced Small Bowel Injury: A Randomized, Placebo-Controlled Trial

Abstract

In a randomized, controlled trial, PPIs increased the risk of short-term nonsteroidal anti-inflammatory drug-induced small bowel injury. UMIN clinical trial registry number: UMIN000008883.

Prescription drugs associated with false-positive results when using faecal immunochemical tests for colorectal cancer screening

“…In addition, Fujimori et al [17] suggested that PPIs not only exacerbated but also induced small intestinal injury in humans. Indeed, a recent randomised placebo-controlled trial [26] showed that PPI use increased the risk of short-term NSAIDinduced small bowel injury. Miyake et al [15] and Lanas et al [14] reported that PPIs were associated with a small increased risk of lower gastrointestinal bleeding after adjusting for potential confounders.…”

Short-course high-dose ibuprofen causing both early and delayed jejunal perforations in a non-smoking man

“…This allows entry of bacteria and their products into the mucosal cells causing further damage. It has recently been reported that the simultaneous use of proton pump inhibition is a risk factor for NSAID-induced small bowel ulceration 4. This is because proton pump inhibitors induce changes in the type and numbers of enteral bacteria.…”

Letter: CYP2C19 polymorphisms and exacerbation of rabeprazole's effects on celecoxib‐induced small bowel injury—authors' reply

“…It is no doubt that the determination of serum rabeprazole concentration and intragastric pH is mandatory to ascertain such speculation, however, we could not evaluate those values because of the lack of serum samples of the PINK study. 5 The genetic samples for the present study were collected after the termination of the PINK study.…”