Proton Pump Inhibitors in Allergy: Benefits and Risks

Robinson, Lacey B.; Ruffner, Melanie A.

doi:10.1016/j.jaip.2022.09.022

Cited by 4 publications

(5 citation statements)

References 89 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, uncontrolled confounding is still a possibility, and further prospective research would be helpful to determine the exact extent of this effect. 53 …”

Section: Discussionmentioning

confidence: 99%

Safety of Proton Pump Inhibitors in Pediatric Population: A Systematic Review

Alla,

Shah,

Seepana

et al. 2024

Global Pediatric Health

View full text Add to dashboard Cite

Objective. Commonly recommended drugs for adults and children include proton pump inhibitors (PPIs), proven effective for treating peptic diseases like stomach ulcers, GERD, and Helicobacter pylori infections in children over 1-year-old. Yet, prolonged PPI use carries higher risks of adverse reactions, prompting this study’s analysis. Methods. We have performed a systematic review of 30 articles, which include a total of 762 505 pediatric patients. Results. Adverse effects were encountered in 6.98% of the population. The 5 most common adverse effects were respiratory tract complications, gastrointestinal complications, urinary tract infections, asthma, and ENT infections. Conclusion. Hence, PPIs should be prescribed only when necessary, and physicians should prioritize patient education when considering their use.

show abstract

“…However, uncontrolled confounding is still a possibility, and further prospective research would be helpful to determine the exact extent of this effect. 53 …”

Section: Discussionmentioning

confidence: 99%

Safety of Proton Pump Inhibitors in Pediatric Population: A Systematic Review

Alla,

Shah,

Seepana

et al. 2024

Global Pediatric Health

View full text Add to dashboard Cite

show abstract

“…Acid suppressant medications (ASM), such as proton pump inhibitors (PPI) and histamine‐2 receptor antagonists (H2RA) are commonly used medications during pregnancy for indications such as gastroesophageal reflux disease. In recent years, prenatal and infant ASM use has been associated with recurrent wheeze and asthma in childhood 4 . However, the relation between prenatal ASM use during pregnancy and childhood respiratory outcomes remains unclear.…”

Section: Characteristic Severe Bronchiolitis Analytic Cohort (N = 246...mentioning

confidence: 99%

“…In recent years, prenatal and infant ASM use has been associated with recurrent wheeze and asthma in childhood. 4 However, the relation between prenatal ASM use during pregnancy and childhood respiratory outcomes remains unclear. Our objective was to investigate the relation of prenatal ASM exposure to bronchiolitis and asthma and to assess whether bronchiolitis mediates the relationship between prenatal ASM and asthma.…”

mentioning

confidence: 99%

“…Prior studies have shown similar results for prenatal and infant ASM exposure being linked to childhood asthma, but not consistently. 4 Proposed mechanisms for the association between ASM and asthma include skewing of the Th1/Th2 pathways and alteration of the gut microbiome leading to dysbiosis and susceptibility of atopic diseases. 4 A recent analysis showed that infant exposure to ASM (not prenatal exposure) was associated with higher risk of asthma.…”

mentioning

confidence: 99%

See 1 more Smart Citation

The relation of prenatal acid suppressant medication exposure to severe bronchiolitis and childhood asthma

Arroyo,

Robinson,

James

et al. 2023

Pediatric Pulmonology

Self Cite

View full text Add to dashboard Cite

“…These may trigger acid re ux symptoms. In addition, some diseases such as sinusitis, asthma and pharyngitis have also been suggested to be related to GERD [8][9][10]. Both gastroesophageal re ux and sinusitis are common in the clinic, it is di cult to establish a direct relationship between them.…”

Section: Introductionmentioning

confidence: 99%

Causal relationships between rhinosiusitis and gastroesophageal reflux disease： a bidirectional two-sample Mendelian randomization study

Chen,

Zhang,

Xie

et al. 2023

Preprint

View full text Add to dashboard Cite

Background Gastroesophageal reflux disease (GERD) is associated with acute and chronic rhinosinusitis (ARS/CRS), although the causal relationship between them is not clear. Methods We conducted a bidirectional two-sample Mendelian randomized study to investigate the causal effects between GERD and rhinosinusitis (RS). The data for GERD and RS were obtained from large sample size genome-wide association studies (GWAS). Single-nucleotide polymorphisms (SNPs) associated with each exposure were considered instrumental variables in this study. We conducted a causal effect analysis using the inverse-variance weighted (IVW)，Weighted median，MR Egger，Simple mode and Weighted mode methods. The inverse-variance weighted and MR - Egger methods were used for the heterogeneity analysis. The MR - Egger model method was adopted for Pleiotropic effects. Results MR analysis showed that GERD had a statistically significant causal effect on ARS (IVW, OR = 1.324, 95% CI 1.177-1.490, p <0.001) and CRS (IVW, OR = 1.365, 95% CI 1.185-1.572, p <0.001).MR analysis showed that CRS had a statistically significant causal effect on GERD (IVW, OR = 1.033, 95% CI 1.009-1.056, p =0.006). However, the MR-Egger model revealed the evidence of horizontal pleiotropy for the causal effect of CRS on GERD (Egger-intercept=0.007, p=0.032). In addition，we did not observe a causal effect of ARS on GERD (IVW, OR = 1.019, 95% CI 0.986-1.053, p=0.269). Conclusions We confirmed the causal effect of GRED on RS, while no causal effect of RS on GERD was found. These studies are expected to provide high-quality causal evidence for the pathogenesis of RS and GERD, and additional ideas for their primary prevention and treatment.

show abstract

Proton Pump Inhibitors in Allergy: Benefits and Risks

Cited by 4 publications

References 89 publications

Safety of Proton Pump Inhibitors in Pediatric Population: A Systematic Review

Safety of Proton Pump Inhibitors in Pediatric Population: A Systematic Review

The relation of prenatal acid suppressant medication exposure to severe bronchiolitis and childhood asthma

Causal relationships between rhinosiusitis and gastroesophageal reflux disease： a bidirectional two-sample Mendelian randomization study

Contact Info

Product

Resources

About