Proton Pump Inhibitors for the Treatment of Laryngopharyngeal Reflux. A Systematic Review

Spantideas, Nikolaos; Drosou, Eirini; Bougea, Anastasia; AlAbdulwahed, Reem

doi:10.1016/j.jvoice.2019.05.005

Cited by 27 publications

(25 citation statements)

References 54 publications

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“…4,10 Although PPIs are considered the mainstay of pharmacological therapy, studies show that PPI therapies fail in approximately 50% of patients with LPR. This unpredictability may be due to the failure of established diagnostic criteria, including the inclusion of patients misdiagnosed with LPR, difficulties in dose standardization, the long duration of treatment, [11][12][13] and the fact that PPIs are less effective in treating nonacid or mixed refluxes, compared to acid reflux. 14 Because PPI therapy is known to be ineffective in a large number of patients with LPR, drugs with suggestive topical effects on the esophageal mucosa, such as alginates and hyaluronic acid, are also prescribed by otolaryngologists.…”

Section: Introductionmentioning

confidence: 99%

“…Although PPIs are considered the mainstay of pharmacological therapy, studies show that PPI therapies fail in approximately 50% of patients with LPR. This unpredictability may be due to the failure of established diagnostic criteria, including the inclusion of patients misdiagnosed with LPR, difficulties in dose standardization, the long duration of treatment, 11–13 and the fact that PPIs are less effective in treating nonacid or mixed refluxes, compared to acid reflux 14 …”

Section: Introductionmentioning

confidence: 99%

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Laryngeal Mucosa Alterations in Mice Model of Gastroesophageal Reflux: Effects of Topical Protection

Figueiredo

Sales

Nicolau³

et al. 2020

The Laryngoscope

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Objectives/Hypothesis: The objectives of this study were to evaluate laryngeal inflammation and mucosal integrity in a murine model of reflux disease and to assess the protective effects of topical agents including alginate, hyaluronic acid, and cashew gum. Study Design: Animal study. Methods: A surgical murine model of reflux disease was evaluated at 3 or 7 days postsurgery, and laryngeal samples were collected to measure inflammation (wet weight and myeloperoxidase [MPO]) and mucosal integrity (transepithelial resistance [TER] and mucosal permeability to fluorescein). Additional groups of animals were administered one of several topical agents (alginate, hyaluronic acid, or cashew gum) daily, and laryngeal inflammation and mucosal integrity were evaluated at 3 days postsurgery. Results: At 3 days, and not 7 days postsurgery, we observed increased laryngeal wet weight and MPO, decreased laryngeal TER, and increased laryngeal mucosa permeability. Alginate partially decreased laryngeal inflammation (wet weight and not MPO) and dramatically improved laryngeal mucosal integrity. Conversely, hyaluronic acid eliminated the inflammation; however, it had no effect on laryngeal mucosal integrity impairment. Cashew gum eliminated laryngeal inflammation as well as the impairment in laryngeal mucosal integrity. Conclusions: This study shows that a surgical model of reflux disease induced laryngeal inflammation and impairment in laryngeal barrier function. These observed alterations were partially attenuated by alginate and hyaluronic acid and completely reversed by cashew gum.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Laryngeal Mucosa Alterations in Mice Model of Gastroesophageal Reflux: Effects of Topical Protection

Figueiredo

Sales

Nicolau³

et al. 2020

The Laryngoscope

View full text Add to dashboard Cite

show abstract

“…A recent systematic review of systematic reviews also failed to recognise the heavily flawed nature of these reviews. 47 In the early 90s, a British Medical Journal article highlighted that, "including all relevant material -good, bad and indifferent -in metaanalysis admits the subjective judgements that meta-analysis was designed to avoid". 48 Across medical disciplines, an estimated 3% of systematic reviews and meta-analyses are of "decent" quality and clinically useful, while 20% are "flawed beyond repair".…”

Section: The Role Of Systematic Reviewsmentioning

confidence: 99%

The acid test: Proton pump inhibitors in persistent throat symptoms: A systematic review of systematic reviews

Cosway

O’Hara

2021

Clinical Otolaryngology

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Persistent throat symptoms comprise a group of interlinked complaints that include dysphonia, a feeling of a lump in the throat-"globus" sensation, the need to clear one's throat, mucus in the throat or catarrh, cough and throat discomfort. "Globus" sensation can affect 40% of the general population in a lifetime 1 and account for an estimated 60 000 ENT consultations in the UK each year 2 These symptoms have long been attributed to extraoesophageal manifestations of gastro-oesophageal reflux disease (GORD), 3 yet there is little high quality evidence to support this assertion. The NHS is estimated to spend around £100million a year on PPIs outside current established indications. 4 However, pooled data have shown a significant increase on cardiovascular mortality from long-term PPI usage. 5 Therefore, it is imperative to understand the role of PPIs in persistent throat symptoms so

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“…Također, unatoč činje nici da je primjena IPPa u liječenju LPRa osnova medikamentne terapije već više desetljeća, superior nost IPPa nad placebom i dalje nije nedvojbeno doka zana. 70,71 Prema nekim studijama u više od 40% paci jenata primjenom empirijske IPPterapije ne opaža se poboljšanje lokalnog nalaza i smanjenje tegoba, a u određenih pacijenata primjenom terapije čak dolazi po pogoršanja simptoma. Autori to pripisuju mješovi tom i nekiselinskom obliku LPRa.…”

Section: Medikamentna Terapijaunclassified

Contemporary approach to the etiology, diagnosis and therapy of laryngopharyngeal reflux – literature review

Hadžibegović

Prstačić

Slipac

et al. 2021

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Proton Pump Inhibitors for the Treatment of Laryngopharyngeal Reflux. A Systematic Review

Cited by 27 publications

References 54 publications

Laryngeal Mucosa Alterations in Mice Model of Gastroesophageal Reflux: Effects of Topical Protection

Laryngeal Mucosa Alterations in Mice Model of Gastroesophageal Reflux: Effects of Topical Protection

The acid test: Proton pump inhibitors in persistent throat symptoms: A systematic review of systematic reviews

Contemporary approach to the etiology, diagnosis and therapy of laryngopharyngeal reflux – literature review

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