Proton Pump Inhibitors for Acute Upper Gastrointestinal Bleeding

Serpico, Mark; Riscinti, Matthew

doi:10.1111/acem.13899

Cited by 1 publication

(2 citation statements)

References 7 publications

(17 reference statements)

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“…28 Proton pump inhibitors (PPIs) are commonly used with oral or intravenous administration to suppress acid secretion, leading to stabilized and mild conditions for blood clotting after neutralizing the acidic surrounding. 29 However, the acid suppression of PPI takes a long time of approximately 12−24 h, resulting in compromised and delayed treatment for severe acute bleeding. The prolonged usage of PPI may also cause unwanted side effects involving headache, depression, or even rhabdomyolysis.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Moreover, acute upper GI bleeding is emerging with increased and severe threats to patients, which may require blood transfusion, endoscopy, or surgery . Proton pump inhibitors (PPIs) are commonly used with oral or intravenous administration to suppress acid secretion, leading to stabilized and mild conditions for blood clotting after neutralizing the acidic surrounding . However, the acid suppression of PPI takes a long time of approximately 12–24 h, resulting in compromised and delayed treatment for severe acute bleeding.…”

Section: Introductionmentioning

confidence: 99%

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Pollen Typhae-Based Magnetic-Powered Microrobots toward Acute Gastric Bleeding Treatment

Yang

Tang

et al. 2022

ACS Appl. Bio Mater.

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Traditional Chinese herbal medicine (TCHM) is the naturally available pharmaceutical with millennia of evolution from ancient China, capable of a superior therapeutic index and minimized unwanted effects on the human body. This work presents a therapeutic microrobotic platform based on pollen typhae (PT), a typical type of TCHM, fabricated by coating porous PT microspheres with Fe 3 O 4 nanoparticles (PT robots) via electrostatic adsorption. The PT robots exhibit effective and controllable motion in various biological media upon external magnetic control and, meanwhile, preserve the inherent hemostasis property of PT. The blood clotting capacity of PT robots is attributed to their stimulation of the endogenous blood coagulation pathway and platelets with increased counts, which could be further improved by their effective magnetic propulsion. The remote magnetic control also allows the manipulation of PT robots in mice stomach, inducing enhanced binding and prolonged retention of PT robots in stomach mucosa. Moreover, PT robots upon magnetic control show an enhanced hemostatic effect in treating the mice bearing acute gastric bleeding compared with other passive groups. This work offers a facile and feasible route to integrate TCHM with manmade micromachines possessing the innate curative features of TCHM. Such a design expanded the versatility of microrobots and can be generalized to vast types of TCHM for broader biomedical applications.

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Section: ■ Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%