Proton Pump Inhibitors and the Risk for Hospital-Acquired Clostridium difficile Infection

Barletta, Jeffrey F.; El-Ibiary, Shareen Y.; Davis, Lindsay E.; Nguyen, Bao; Raney, Carrington R. K.

doi:10.1016/j.mayocp.2013.07.004

Cited by 66 publications

(47 citation statements)

References 24 publications

(32 reference statements)

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“…Their high safety, efficacy and wide distribution lead to overuse, inappropriate dosage and excessive durations of treatment. Howell et al [15] reported that increasing levels of pharmacologic acid suppression are associated with increased risks of nosocomial Clostridium difficile (CD) infection and Barletta et al [16] reported that the duration of PPI therapy is significantly associated with CD infection and suggested consideration of restricting PPI use, given the short exposure time. However, more recent studies have offered conflicting viewpoints regarding the association between PPI use and increased risk of CD infection [17][18][19] .…”

Section: Terminologymentioning

confidence: 99%

Two-week treatment with proton pump inhibitor is sufficient for healing post endoscopic submucosal dissection ulcers

Arai¹,

Matsumura²,

Okimoto³

et al. 2014

WJG

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Section: Terminologymentioning

confidence: 99%

Two-week treatment with proton pump inhibitor is sufficient for healing post endoscopic submucosal dissection ulcers

Arai¹,

Matsumura²,

Okimoto³

et al. 2014

WJG

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“…Studies of this topic have been carried out in different countries [11][12][13]. However, few reports have focused on CDI in China.…”

Section: Introductionmentioning

confidence: 99%

Clinical characterization and risk factors of Clostridium difficile infection in elderly patients in a Chinese hospital

Zhang

Dong

Jiang

et al. 2015

J Infect Dev Ctries

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Introduction: Clostridium difficile is a common cause of nosocomial diarrhea, especially in elderly patients. This study aimed to analyze the clinical features and assess the risk factors associated with Clostridium difficile infection (CDI) in elderly hospitalized patients. Methodology: A retrospective case-control study was conducted among elderly hospitalized patients (> 60 years of age) in a Chinese tertiary hospital between 2010 and 2013. Fifty-two CDI patients and 150 randomly selected non-CDI patients were included in the study. Clinical features of CDI and non-CDI patients were compared by appropriate statistical tests. Logistic regression analyses were performed on a series of factors to determine the risk factors for CDI among the elderly hospitalized patients. Results: The elderly CDI patients showed higher leukocyte counts, lower serum albumin levels, longer duration of hospital stay, and higher mortality compared to the non-CDI patients. The proportion of patients admitted to the intensive care unit or exposed to gastric acid suppressants was also significantly different (p < 0.05) between the two groups. Multivariate analysis indicated that serum creatinine (OR 1.004; 95% CI 1.001-1.008), surgical intervention (OR 6.132; 95% CI 2.594-14.493), the number of comorbidities (OR 2.573; 95% CI 1.353-4.892), gastrointestinal disease (OR 4.670; 95% CI 2.002-10.895), and antibiotic use (OR 6.718; 95% CI 2.846-15.859) were independently associated with CDI. Conclusions: This study revealed several risk factors for CDI among elderly hospitalized patients. These findings will increase the knowledge concerning this disease and provide information regarding the control and prevention of CDI in the elderly.

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“…A few studies reported no increased risk of developing CDI if patients are exposed to a PPI . However, significantly more clinical studies found the use of a PPI among hospitalized patients as a risk factor for the development of CDI …”

Section: Discussionmentioning

confidence: 99%

Evaluation of Risk Factors forClostridium difficileInfection in Hematopoietic Stem Cell Transplant Recipients

et al. 2017

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Proton Pump Inhibitors and the Risk for Hospital-Acquired Clostridium difficile Infection

Abstract: The duration of PPI therapy is significantly associated with CDI. Clinicians should strongly consider restricting PPI use given the short exposure time associated with this increased risk.

Cited by 66 publications

References 24 publications

Two-week treatment with proton pump inhibitor is sufficient for healing post endoscopic submucosal dissection ulcers

Two-week treatment with proton pump inhibitor is sufficient for healing post endoscopic submucosal dissection ulcers

Clinical characterization and risk factors of Clostridium difficile infection in elderly patients in a Chinese hospital

Evaluation of Risk Factors forClostridium difficileInfection in Hematopoietic Stem Cell Transplant Recipients

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