Proton Pump Inhibitor Therapy for Suspected GERD-Related Chronic Laryngitis: A Meta-Analysis of Randomized Controlled Trials

Qadeer, Mohammed A.; Phillips, Christopher; López, Rocío; Steward, David L.; Noordzij, J. Pieter; Wo, John M.; Suurna, Maria V.; Havas, Thomas; Howden, Colin W.; Vaezi, Michael F.

doi:10.1111/j.1572-0241.2006.00844.x

Cited by 254 publications

(127 citation statements)

References 33 publications

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“…A subsequent meta-analysis of the placebo-controlled studies in laryngopharyngeal reflux has reported minimal therapeutic benefit of PPIs over placebo. 76 GERD has also been shown to be present in 50-80% of asthmatic patients. 77,78 Reports of GERD-related symptoms in adults with asthma range from 65% to 77%.…”

Section: -74mentioning

confidence: 99%

Unmet Needs in the Treatment of Gastroesophageal Reflux Disease

Dickman

Maradey–Romero

Gingold‐Belfer

et al. 2015

J Neurogastroenterol Motil

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Gastroesophageal reflux disease (GERD) is a highly prevalent gastrointestinal disorder. Proton pump inhibitors have profoundly revolutionized the treatment of GERD. However, several areas of unmet need persist despite marked improvements in the therapeutic management of GERD. These include the advanced grades of erosive esophagitis, nonerosive reflux disease, maintenance treatment of erosive esophagitis, refractory GERD, postprandial heartburn, atypical and extraesophageal manifestations of GERD, Barrett's esophagus, chronic protein pump inhibitor treatment, and post-bariatric surgery GERD. Consequently, any future development of novel therapeutic modalities for GERD (medical, endoscopic, or surgical), would likely focus on the aforementioned areas of unmet need.

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Section: -74mentioning

confidence: 99%

Unmet Needs in the Treatment of Gastroesophageal Reflux Disease

Dickman

Maradey–Romero

Gingold‐Belfer

et al. 2015

J Neurogastroenterol Motil

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show abstract

“…Th e experience with treating laryngeal symptoms attributed to refl ux disease is comparable. A meta-analysis of eight randomized controlled trials found that PPI therapy had no signifi cant advantage over placebo in achieving improvement of symptoms of suspected GERD-related chronic laryngitis (RR 1.28, 95 % CI 0.94 to 1.74) ( 141 ).…”

Section: Summary Of the Evidencementioning

confidence: 99%

Guidelines for the Diagnosis and Management of Gastroesophageal Reflux Disease

Katz¹,

Gerson²,

Vela³

2013

American Journal of Gastroenterology

1,531

1,430

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“…Laryngoscopy and monitoring pH are the methods used for the diagnosis of LPR (13), though their real specificity and sensitivity values have been interrogated (18). Traditionally, successful empirical treatment with proton pump inhibitors is regarded as a diagnostic method (10); however this method has its limitations and is also questioned by the literature (18,19). In this study, the criteria used to diagnose "reflux laryngitis disease" were the following laryngoscopic findings: arytenoid hyperemia and laryngeal mucosa and the vocal folds edema (posterior laryngitis).…”

Section: Discussionmentioning

confidence: 99%

Substernal goiter and laryngopharyngeal reflux

Rodrigues

Filho²,

Matos³

et al. 2017

Arch. Endocrinol. Metab.

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Objective: This study aims to compare the prevalence of laryngopharyngeal reflux signs between two groups of patients undergoing thyroidectomy for voluminous goiter: substernal goiters and voluminous cervical goiter without thoracic extension. Subjects and methods: A retrospective case-control study was performed with data retrieved of the charts of the patients submitted to thyroidectomies occurred at a tertiary care center (Head and Neck Surgery Department, University of São Paulo Medical School) between 2010 and 2014. The selected thyroidectomies were allocated in two groups for study: patients with substernal goiters and patients with voluminous cervical goiter without thoracic extension. Cervical goiters were selected by ultrasonography mensuration. Clinical criterion was used to define substernal goiter. Results: The average thyroid volume in patients with substernal goiter was significantly greater than the average volume in patients with only cervical goiter (p < 0.001). The prevalence of signs of reflux laryngitis at laryngoscopy was significantly greater in substernal goiter patients (p = 0.036). Moreover, substernal goiter was considered as the unique independent variable for high reflux laryngitis signs at laryngoscopy (OR = 2.75; CI95%: 1.05-7.20; p = 0.039) when compared to only cervical goiter patients. Conclusion: This study shows a significant association between substernal goiters and signs of laryngopharyngeal reflux at preoperative laryngoscopy. Therefore, when compared with voluminous cervical goiters, the substernal goiters increase the chance of reflux laryngitis signs in patients. Arch Endocrinol Metab. 2017;61(3):348-53.

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Proton Pump Inhibitor Therapy for Suspected GERD-Related Chronic Laryngitis: A Meta-Analysis of Randomized Controlled Trials

Abstract: PPI therapy may offer a modest, but nonsignificant, clinical benefit over placebo in suspected GERD-related CL. Validated diagnostic guidelines may facilitate the recognition of those patients most likely to respond favorably to PPI treatment.

Cited by 254 publications

References 33 publications

Unmet Needs in the Treatment of Gastroesophageal Reflux Disease

Unmet Needs in the Treatment of Gastroesophageal Reflux Disease

Guidelines for the Diagnosis and Management of Gastroesophageal Reflux Disease

Substernal goiter and laryngopharyngeal reflux

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