Proton Pump Inhibitor Therapy before and after Endoscopic Submucosal Dissection: A Review

Sugimoto, Mitsushige; Jang, Jin Seok; Yoshizawa, Yashiro; Osawa, Satoshi; Sugimoto, Ken; Sato, Yoshihiko; Furuta, Takahisa

doi:10.1155/2012/791873

Cited by 14 publications

(11 citation statements)

References 89 publications

(116 reference statements)

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“…[4][5][6] We wished to clarify clinical and pharmacological parameters influencing the healing rate of post-ESD ulcers, and investigated whether vonoprazan has increased efficacy in preventing complications in this setting. 1,7 In addition, because concurrent H. pylori infection slows the rate of peptic ulcer healing, 8 concurrent infection, and its eradication, might affect the healing rate of post-ESD ulcers.…”

Section: Sirsmentioning

confidence: 99%

Letter: a potassium‐competitive acid blocker vs a proton pump inhibitor for healing endoscopic submucosal dissection‐induced artificial ulcers after treatment of gastric neoplasms

Ban

Sugimoto

Otsuka

et al. 2017

Aliment Pharmacol Ther

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Section: Sirsmentioning

confidence: 99%

Letter: a potassium‐competitive acid blocker vs a proton pump inhibitor for healing endoscopic submucosal dissection‐induced artificial ulcers after treatment of gastric neoplasms

Ban

Sugimoto

Otsuka

et al. 2017

Aliment Pharmacol Ther

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“…Endoscopic submucosal dissection (ESD) is a procedure that enables en bloc resection of gastric neoplastic lesions that are difficult to resect via conventional endoscopic mucosal resection (EMR)[ 1 , 2 ]. ESD is first-line treatment for early-stage gastrointestinal cancer[ 3 - 5 ].…”

Section: Introductionmentioning

confidence: 99%

Usefulness of the clip-flap method of endoscopic submucosal dissection: A randomized controlled trial

Ban¹,

Sugimoto²,

Otsuka³

et al. 2018

WJG

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AIMTo prospectively investigate the efficacy and safety of clip-flap assisted endoscopic submucosal dissection (ESD) for gastric tumors.METHODSFrom May 2015 to October 2016, we enrolled 104 patients with gastric cancer or adenoma scheduled for ESD at Shiga University of Medical Science Hospital. We randomized patients into two subgroups using the minimization method based on location of the tumor (upper, middle or lower third of the stomach), tumor size (< 20 mm or > 20 mm) and ulcer status: ESD using an endoclip (the clip-flap group) and ESD without an endoclip (the conventional group). Therapeutic efficacy (procedure time) and safety (complication: Gastrointestinal bleeding and perforation) were assessed.RESULTSEn bloc resection was performed in all patients. Four patients had delayed bleeding (3.8%) and two had perforation (1.9%). No significant differences in en bloc resection rate (conventional group: 100%, clip flap group: 100%), curative endoscopic resection rate (conventional group: 90.9%, clip flap group: 89.8%, P = 0.85), procedure time (conventional group: 70.8 ± 46.2 min, clip flap group: 74.7 ± 53.3 min, P = 0.69), area of resected specimen (conventional group: 884.6 ± 792.1 mm2, clip flap group: 1006.4 ± 1004.8 mm2, P = 0.49), delayed bleeding rate (conventional group: 5.5%, clip flap group: 2.0%, P = 0.49), or perforation rate (conventional group: 1.8%, clip flap group: 2.0%, P = 0.93) were found between the two groups. Less-experienced endoscopists did not show any differences in procedure time between the two groups.CONCLUSIONFor patients with early-stage gastric tumors, the clip-flap method has no advantage in efficacy or safety compared with the conventional method.

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“…Below pH 4.0, fibrin clots are dissolved. 19,20 Therefore, gastric pH must be kept >5.4 to prevent bleeding.…”

Section: Discussionmentioning

confidence: 99%

Effects of preoperative proton pump inhibitor administration on bleeding after gastric endoscopic submucosal dissection: A systematic review and meta‐analysis

et al. 2016

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Background and aim: The efficacy of using proton pump inhibitors (PPIs) prior to gastric endoscopic submucosal dissection (ESD) to reduce gastric bleeding remains controversial. This study aimed to systematically review the literature to evaluate the efficacy of preoperative PPI use to reduce post-ESD bleeding. Methods: PubMed, the Cochrane library, and the Igaku-Chuo-Zasshi database were searched to identify randomized trials eligible for inclusion in the systematic review. Data from four studies (406 patients) were combined to calculate a pooled risk difference (RD) for developing post-ESD bleeding. Results: Compared with patients who received no premedication, the pooled RD for post-ESD bleeding in patients who received preoperavive PPI was -0.027 (95% confidence interval: -0.070-0.017, p ¼ 0.228), without significant heterogeneity. Preoperavive PPI use significantly increased gastric pH (weighted mean difference: 1.289, 95% CI: 0.227-2.352, p ¼ 0.0174). Conclusions: This systematic review and meta-analysis showed that premedication with PPI had no advantage for the prevention of post-ESD bleeding, despite increasing gastric pH.

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Proton Pump Inhibitor Therapy before and after Endoscopic Submucosal Dissection: A Review

Cited by 14 publications

References 89 publications

Letter: a potassium‐competitive acid blocker vs a proton pump inhibitor for healing endoscopic submucosal dissection‐induced artificial ulcers after treatment of gastric neoplasms

Letter: a potassium‐competitive acid blocker vs a proton pump inhibitor for healing endoscopic submucosal dissection‐induced artificial ulcers after treatment of gastric neoplasms

Usefulness of the clip-flap method of endoscopic submucosal dissection: A randomized controlled trial

Effects of preoperative proton pump inhibitor administration on bleeding after gastric endoscopic submucosal dissection: A systematic review and meta‐analysis

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