Proton pump inhibitor–induced rhabdomyolysis and hyponatremic delirium

Bebarta, Vikhyat S.; King, James A.; McDonough, Marie

doi:10.1016/j.ajem.2007.08.026

Cited by 27 publications

(24 citation statements)

References 2 publications

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“…It is now known that hyponatremia can occur several days or months after the initiation of proton pump inhibitors, although these drugs were initially overlooked as a cause of hyponatremia. A case of hyponatremic delirium leading to rhabdomyolysis has also been reported 26. It is well known that potassium level alterations are responsible for conduction disturbances, dangerous arrhythmias, cardiogenic syncope, and sudden cardiac death.…”

Section: Discussionmentioning

confidence: 99%

Adverse drug reactions in older patients: an Italian observational prospective hospital study

Conforti

Costantini²,

Zanetti³

et al. 2012

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BackgroundIn adults over 65 years of age, the frequency of adverse drug reaction (ADRs) related hospital admissions is higher than in younger adults, and the frequency of ADRs occurring during hospital stay highly ranges. The review was designed to evaluate the frequency of ADRs, both resulting in hospital admission and occurring during the hospital stay of older patients, while identifying the types of reactions and the associated drugs.MethodsAge, sex, date, and diagnosis of admission of all patients aged 65 and over admitted in three geriatric wards of University Hospital of Verona, Italy, from February to July 2009 were registered by nurses on a special form. In the specific cases of admissions caused by an ADR as well as in the cases of an ADR occurring during the hospital stay, the type of reactions and the suspected drugs were also registered by nurses and physicians involved in the study.ResultsDuring the six months of the study, 1023 patients matched the inclusion criteria and were included in the study. One hundred fourteen hospital admissions (11.1%) were caused by ADRs, while 256 patients (25.0%) had an ADR during their hospital stay. The duration of hospital stay was significantly longer in patients who developed an ADR during their time in hospital, 18.7 (95% CI: 17.2–20.1) days versus 12.6 (95% CI: 11.9–13.3) days. Electrolyte disorders, gastrointestinal disorders, anemia, and International Normalized Ratio increase were the more frequent observed ADRs, with diuretics, antithrombotic agents, and antibacterials as the main involved drugs. Our study confirms that ADRs are an important cause of hospitalization in older patients. In addition, the frequency of ADRs occurring during hospital stay is high and causes prolonged hospitalization.

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Section: Discussionmentioning

confidence: 99%

Adverse drug reactions in older patients: an Italian observational prospective hospital study

Conforti

Costantini²,

Zanetti³

et al. 2012

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“…PPIs have also been identified as a potential factor in the development of vitamin B12 deficiency, a factor that may also contribute towards the development of dementia . The findings of case studies and small observational studies have suggested a link between PPI use and acute cognitive impairment …”

Section: Introductionmentioning

confidence: 99%

Dementia, cognitive impairment and proton pump inhibitor therapy: A systematic review

Batchelor

Gilmartin

Kemp

et al. 2017

J of Gastro and Hepatol

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Based on the current published literature, this systematic review has identified that the reported association between PPI use and dementia is limited by methodological issues and conflicting results. Further longitudinal studies with robust bias limitation are required to explore the use of PPIs and dementia or acute cognitive impairment, and to ascertain the existence of any causal relationships.

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“…15,16 Also, esomeprazole-induced rhabdomyolysis has been reported but is typically associated with hyponatremia when considered as a cause of rhabdomyolysis. 17 As our patient had low-to-normal serum sodium concentrations, it is unlikely that hyponatremia was the cause of his symptoms.…”

Section: Discussionmentioning

confidence: 96%