Proton pump inhibitor in upper gastrointestinal fecal microbiota transplant: A systematic review and analysis

Abstract

Background and Aims Fecal microbiota transplantation (FMT) is used in recurrent Clostridioides difficile infections. However, protocols are facility dependent, and one variable is whether pre‐procedural proton pump inhibitors (PPIs) are given. In theory, PPIs reduce acidity and protect the transplanted microbiome for the most potent dose. We conducted a systematic review to study the effect of PPIs on FMT delivered by upper gastrointestinal (GI) routes. Methods We searched Pubmed/Medline, Cochrane Library, Embase, Scopus, and Web of Science through December 16, 2018 using variations of keywords “fecal microbiota transplant” and “Clostridium difficile infection.” Two authors independently reviewed 4210 results and found 11 qualifying studies with data on upper GI FMT, use of PPIs, and the rate of treatment failure at follow‐up. Results Of 233 included patients, treatment failure occurred in 20.6% of those with use of PPIs versus 22.6% in the group without (relative risk 0.91; confidence interval 0.56–1.50). Limitations include the lack of studies directly comparing outcomes based on use of PPIs and inability to control for possible confounders such as chronic PPI use, amount of stool transplanted, and pre‐FMT antibiotics. Conclusions We did not find evidence supporting a clinically significant benefit from routine use of PPIs in FMT protocol. It is possible that the theoretical benefit from improved survival of transplanted microbiota is offset by negative effects on the microbiome. We suggest that routine use of PPIs in upper GI FMT be reconsidered. Further investigation is needed to optimize protocols for safety and efficacy.

The significance of granulomas in Crohn's disease and inflammatory bowel disease epidemiology in Asia

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Is there a role of faecal microbiota transplantation in reducing antibiotic resistance burden in gut? A systematic review and Meta-analysis

“…Furthermore, a meta-analysis from Hong et al. [ 74 ] proved there was no statistically significant benefit from the routine use of pre-treatment with PPIs in the FMT protocol compared to no PPI-used protocols.…”

Romanian National Guideline on Translating Fecal Microbiota Transplantation Applications related to Clostridioides difficile Infections into the Local Clinical Practice

“…PPIs might change microbiota [118] with moderate alterations occurring to both upper and distal gut microbiota [119]. No clinically significant benefit from routine use of PPIs in FMT protocols were identified [120,121]. Considering all these aspects, the WG suggested that PPI use should be avoided peri-procedurally, considering conflicting results on PPIs' effect in this setting, until further steps are taken to optimize protocols for safety and efficacy.…”