Proton pump inhibitor-enhanced nanocatalytic ferroptosis induction for stimuli-responsive dual-modal molecular imaging guided cancer radiosensitization

Zheng, Shuting; Hu, Hai; Hou, Meirong; Zhu, Kai; Wu, Zede; Li, Qi; Xia, Hui; Liu, Guoqiang; Ren, Yunyan; Xu, Yikai; Yan, Changqing; Zhao, Bingxia

doi:10.1016/j.actbio.2023.03.011

Cited by 7 publications

(2 citation statements)

References 38 publications

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“…Silver nanoparticles are another type of metal NP that can trigger ferroptosis. These NPs achieve this by ROS (G. Zheng S. et al, 2023 ). Christina M. Snyder and her team have shown that silver nanoparticles can be particularly effective against triple-negative breast cancer.…”

Section: Types Of Nanoparticles Capable Of Inducing Ferroptosis In Ca...mentioning

confidence: 99%

Ferroptosis resistance in cancer cells: nanoparticles for combination therapy as a solution

Adzavon,

Zhao,

et al. 2024

Front. Pharmacol.

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Ferroptosis is a form of regulated cell death (RCD) characterized by iron-dependent lipid peroxidation. Ferroptosis is currently proposed as one of the most promising means of combating tumor resistance. Nevertheless, the problem of ferroptosis resistance in certain cancer cells has been identified. This review first, investigates the mechanisms of ferroptosis induction in cancer cells. Next, the problem of cancer cell resistance to ferroptosis, as well as the underlying mechanisms is discussed. Recently discovered ferroptosis-suppressing biomarkers have been described. The various types of nanoparticles that can induce ferroptosis are also discussed. Given the ability of nanoparticles to combine multiple agents, this review proposes nanoparticle-based ferroptosis cell death as a viable method of circumventing this resistance. This review suggests combining ferroptosis with other forms of cell death, such as apoptosis, cuproptosis and autophagy. It also suggests combining ferroptosis with immunotherapy.

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Section: Types Of Nanoparticles Capable Of Inducing Ferroptosis In Ca...mentioning

confidence: 99%

Ferroptosis resistance in cancer cells: nanoparticles for combination therapy as a solution

Adzavon,

Zhao,

et al. 2024

Front. Pharmacol.

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“…Thus, it is hypothesized that the Fenton reaction could be directly introduced to destroy organic substances within cancer cells, thereby inducing cancer cell death. In the Fenton reaction, H 2 O 2 reacts with iron ions to generate ·OH [ 26 ]. Hydroxyl radicals are one of the most important intermediate products, and they are typically considered to be the most toxic ROS generated in the Fenton reaction.…”

Section: Introductionmentioning

confidence: 99%

Advancements in the Application of the Fenton Reaction in the Cancer Microenvironment

Ou,

Aodeng,

2023

Pharmaceutics

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Cancer is a complex and multifaceted disease that continues to be a global health challenge. It exerts a tremendous burden on individuals, families, healthcare systems, and society as a whole. To mitigate the impact of cancer, concerted efforts and collaboration on a global scale are essential. This includes strengthening preventive measures, promoting early detection, and advancing effective treatment strategies. In the field of cancer treatment, researchers and clinicians are constantly seeking new approaches and technologies to improve therapeutic outcomes and minimize adverse effects. One promising avenue of investigation is the utilization of the Fenton reaction, a chemical process that involves the generation of highly reactive hydroxyl radicals (·OH) through the interaction of hydrogen peroxide (H2O2) with ferrous ions (Fe2+). The generated ·OH radicals possess strong oxidative properties, which can lead to the selective destruction of cancer cells. In recent years, researchers have successfully introduced the Fenton reaction into the cancer microenvironment through the application of nanotechnology, such as polymer nanoparticles and light-responsive nanoparticles. This article reviews the progress of the application of the Fenton reaction, catalyzed by polymer nanoparticles and light-responsive nanoparticles, in the cancer microenvironment, as well as the potential applications and future development directions of the Fenton reaction in the field of tumor treatment.

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Recent Advances in Polyoxometalate Based Nanoplatforms Mediated Reactive Oxygen Species Cancer Therapy

Yue,

Wang,

et al. 2023

Chemistry An Asian Journal

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The potential of reactive oxygen species (ROS) cancer therapy in tumor treatment has been greatly enhanced by the introduction of catalytically superior polyoxometalate (POM)‐based nanoplatforms, mainly composed of atomic clusters consisting of pre‐transition metals and oxygen. These nanoplatforms have unique advantages, such as Fenton activity at neutral pH, induction of cellular ferroptosis instead of just apoptosis, and sensitivity to external field stimulation. However, there are also inevitable challenges such as neutralization of ROS by the antioxidant system of the tumor microenvironment (TME), hypoxia, and limited hydrogen peroxide concentrations. This review article aims to provide an overview of recent research advancements in POM‐based nanoplatforms for ROS therapy from the perspective of chemical reactions and biological processes, addressing endogenous and exogenous factors that affect the antitumor efficacy. Endogenous factors include the mechanism of ROS generation by POM, the impact of pH and antioxidant systems on POM, and the various manners of tumor cell death. Exogenous stimuli mainly include light, heat, X‐rays, and electricity. The article analyzes the specific mechanisms of action of each influencing factor in the first two sections, concluding with the limitations of the present study and some possible directions for future research.

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Proton pump inhibitor-enhanced nanocatalytic ferroptosis induction for stimuli-responsive dual-modal molecular imaging guided cancer radiosensitization

Cited by 7 publications

References 38 publications

Ferroptosis resistance in cancer cells: nanoparticles for combination therapy as a solution

Ferroptosis resistance in cancer cells: nanoparticles for combination therapy as a solution

Advancements in the Application of the Fenton Reaction in the Cancer Microenvironment

Recent Advances in Polyoxometalate Based Nanoplatforms Mediated Reactive Oxygen Species Cancer Therapy

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