Proton Pump Inhibitor and Histamine-2 Receptor Antagonist Use and Iron Deficiency

Lam, Jameson R.; Schneider, Jennifer L.; Quesenberry, Charles P.; Corley, Douglas A.

doi:10.1053/j.gastro.2016.11.023

Cited by 216 publications

(261 citation statements)

References 23 publications

(18 reference statements)

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“…Second, PPIs might act as an inverse γ-secretase modulator by increasing the activity of the β-secretase BACE1, resulting in accumulation of Aβ (22). Third, use of PPIs has been shown to be associated with vitamin B12 deficiency as a result of suboptimal GI absorption (23). Vitamin B12 deficiency is known to negatively affect cognitive function as a result of impaired DNA synthesis, methylation, and homocysteine neurotoxicity (24,25).…”

Section: Discussionmentioning

confidence: 99%

Proton pump inhibitors and risk of dementia

Wijarnpreecha¹,

Thongprayoon²,

Panjawatanan³

et al. 2016

Ann. Transl. Med.

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Background: Proton pump inhibitors (PPIs) are one of the most commonly prescribed medications. Recent studies have raised a concern over increased risk of dementia among PPIs users but the results of those studies were inconsistent. We conducted this systematic review and meta-analysis to summarize all available data.Methods: A literature search was performed in MEDLINE and EMBASE database from inception to April 2016.Observational studies that reported risk of dementia among PPIs users compared with non-users were included.Point estimates were extracted from individual studies and pooled risk ratios (RR) with 95% confidence intervals (CI) were calculated using a random-effect, generic inverse variance method.Results: Four studies were included in the analysis. Pooled RR of dementia among PPIs users compared with non-users was 1.08 (95% CI, 0.82-1.43). Sensitivity analysis including only cohort studies demonstrated a higher risk with pooled RR of 1.44 (95% CI, 1.36-1.52). Conclusions:Our study demonstrated an increased risk of dementia among PPIs users. Whether this association is causal requires further investigations.

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Section: Discussionmentioning

confidence: 99%

Proton pump inhibitors and risk of dementia

Wijarnpreecha¹,

Thongprayoon²,

Panjawatanan³

et al. 2016

Ann. Transl. Med.

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“…Also long-term PPI assumption has been related with vitamin B12 deficiency in elderly patients (Valuck and Ruscin, 2004;Lam et al, 2013;Linder et al, 2016). Although this finding should be confirmed in prospective trials, this kind of deficit should be taken into account in patients receiving PPIs for long time.…”

Section: Vitamin Deficiencymentioning

confidence: 95%

Proton Pump Inhibitors in cancer patients: How useful they are? A review of the most common indications for their use

Numico

Fusco

Franco

et al. 2017

Critical Reviews in Oncology/Hematology

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“…PPI use has also been associated with an increased risk of bone fracture and Vitamin B12 deficiency [45]. PPI's44 inhibit the liver P450 enzyme system and may interact with other drugs [46].…”

Section: Current Medication Management Of Gerdmentioning

confidence: 99%

Effect on Acid Reflux Symptoms Occurring during Sleep of an Oral Adhering Disc Containing only Food Ingredients

Burgess¹,

Kärcher²

2017

J Gastrointest Dig Syst

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The aim of this double-blinded, randomized, controlled study was to determine if OraCoat XyliMelts, an over the counter, dissolvable, adhering disc used to reduce excessive day time or night time dry mouth by increasing salivation, would also reduce reflux and heartburn symptoms occurring during sleep among subjects suffering from both GERD and xerostomia. Subjects submitted 14 days of baseline data by answering questions and were then randomized into one of two groups: one receiving a dry mouth gel (control) and a second receiving a disc (product of interest). Neither the identities of the two products nor the manufacturers of the products was revealed to subjects. Answers to the same set of questions were then collected for an additional 14 days as the supplied products were used. The accumulated data were evaluated for pre-post treatment changes within and between groups. Variables included reported heartburn, reflux, reflux taste, hoarseness, dry mouth, and antacid use. The results showed a significant decrease in the severity of the above symptoms of GERD with both disc and gel use, although improvement was greatest for those using the discs. Comparison between the gel and disc groups for most symptoms did not reveal significant differences. For heartburn, subjects using the discs perceived significantly less pain than subjects using the gel. We conclude that the use of certain products intended to reduce dry mouth during sleep, including OraCoat XyliMelts, may be an effective adjunctive remedy for reducing reflux and heartburn symptoms in patients with GERD and xerostomia.

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Proton Pump Inhibitor and Histamine-2 Receptor Antagonist Use and Iron Deficiency

Abstract: Among patients without known risk factors for iron deficiency, gastric acid inhibitor use for ≥2 years was associated with an increased subsequent risk of iron deficiency. The risk increased with increasing potency of acid inhibition and decreased after medication discontinuation.

Cited by 216 publications

References 23 publications

Proton pump inhibitors and risk of dementia

Proton pump inhibitors and risk of dementia

Proton Pump Inhibitors in cancer patients: How useful they are? A review of the most common indications for their use

Effect on Acid Reflux Symptoms Occurring during Sleep of an Oral Adhering Disc Containing only Food Ingredients

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