Proton or photon irradiation for hemangiomas of the choroid? A retrospective comparison

Clinical use of photodynamic therapy in ocular tumors

“…12,197 A general literature search of the last 20 years for treatment modalities of diffuse choroidal hemangioma revealed 77 cases. The most frequent treatment modality for diffuse choroidal hemangioma is external beam radiotherapy, with photons in 31 cases 73,74,81,113,138,148,162 and with protons in 21 cases. 47,81,221 The third most common method reported in the literature is PDT, which was used in 10 cases, where 7 cases were followed up after at least 6 months, 11,39,88,126,179,203 and 3 cases in 3 studies were followed up in less than 6 months.…”

Congenital vascular malformations of the retina and choroid

“…44,48 If PDT is not available or is unsuccessful, or if the disease is too advanced, then alternative treatments include transpupillary thermotherapy, external beam, or proton beam radiotherapy. 37,[50][51][52][53][54][55][56] Follow-up examinations should include ultrasound measurement of tumour dimensions and OCT examinations of macular oedema, as appropriate. A treatment effect can usually be seen within 6 months.…”

“…Most cases reported in the literature have therefore been treated with lens-sparing external beam radiotherapy or proton beam radiotherapy. 40,50,56,62 In about 75% of patients, regression of the haemangioma and resolution of the secondary exudative retinal detachment can be achieved by these methods; however, a minority of patients develop radiation retinopathy. 40,50,62 Several reports of successful PDT for diffuse choroidal haemangioma ( Figure 11) have Figure 10.…”

“…40,50,56,62 In about 75% of patients, regression of the haemangioma and resolution of the secondary exudative retinal detachment can be achieved by these methods; however, a minority of patients develop radiation retinopathy. 40,50,62 Several reports of successful PDT for diffuse choroidal haemangioma ( Figure 11) have Figure 10. Regression of the diffuse haemangioma and the exudative retinal detachment following Verteporfin photodynamic therapy with standard parameters and four overlapping spots covering the haemangioma at the posterior pole.…”

The Effectiveness and Safety of Proton Radiation Therapy for Indications of the Eye

“…These reported on 121 unique studies References excluded (n = 141). Reasons for exclusion were: no primary study (48), no human subjects (5), no proton therapy (61), < 10 patients (20), no clinical outcomes (7) quently reported; disease-specific survival was at least 75% at 3-10 years in three studies (# 3, 5, and 6). Overall survival varied between 15.9% and 83% at 3-5 years (# 3, 4, 5, and 11).…”