Proton MRS of the peritumoral brain

Chernov, Mikhail; Kubo, Osami; Hayashi, Motohiro; Izawa, Masahiro; Maruyama, Takashi; Usukura, Masao; Ono, Yuko; Hori, Tomokatsu; Takakura, Kintomo

doi:10.1016/j.jns.2004.11.039

Cited by 41 publications

(28 citation statements)

References 17 publications

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“…12,19,20,22 In particular, Chernov et al 12 examined peritumoral brain tissue and found a significant reduction in the NAA/Cr and NAA/Cho ratios and a more frequent presence of Lac compared with the healthy brain. In their study, the NAA level was lowest in cases with a higher content of Lac in the lesion than in the perilesional brain tissue, which suggests that Lac diffuses from tumoral into peritumoral tissue.…”

Section: Discussionmentioning

confidence: 99%

“…Two patients, not surgically treated, were affected by metastases because of the presence of a primary distant tumor with multiple brain lesions. According to Chernov et al, 12 the extension of perilesional edema evaluated by T2-weighted MR images was graded as mild in 2 patients, moderate in 6, and severe in 5. All patients received dexamethasone as the only anti-edema drug.…”

Section: Subjectsmentioning

confidence: 99%

“…9 The advent of functional MR techniques such as diffusion and perfusion imaging and spectroscopy has opened the door to in vivo dynamic and metabolic assessments. [10][11][12][13] MR spectroscopy studies have investigated brain edema in experimental models 14,15 and in the clinical setting with the use of 1.5T systems. [16][17][18][19][20][21][22] MR spectroscopy has been boosted further by the clinical application of high-field-strength devices by offering the advantages of better signal-to-noise ratio and increased spectral resolution, thereby disclosing more metabolites and extending the range of metabolic information.…”

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confidence: 99%

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Metabolic Findings on 3T 1H-MR Spectroscopy in Peritumoral Brain Edema

Ricci¹,

Bacci²,

Tugnoli³

et al. 2007

American Journal of Neuroradiology

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Section: Discussionmentioning

confidence: 99%

Section: Subjectsmentioning

confidence: 99%

mentioning

confidence: 99%

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Metabolic Findings on 3T 1H-MR Spectroscopy in Peritumoral Brain Edema

Ricci¹,

Bacci²,

Tugnoli³

et al. 2007

American Journal of Neuroradiology

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“…Moderate edema was defined as extension of edema beyond 2 cm from the margin of the lesion up to one half of the cerebral hemisphere, and severe perilesional brain edema was defined as extension of edema to more than half of the cerebral hemisphere. 13 The scolex appeared as a hyperdense/enhancing tiny nodule, within the granuloma.…”

Section: Methodsmentioning

confidence: 99%

Predictors of Lesion Calcification in Patients with Solitary Cysticercus Granuloma and New-Onset Seizures

Mahajan¹,

Malhotra²,

Garg³

et al. 2016

The American Society of Tropical Medicine and Hygiene

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Abstract. Solitary cysticercus granuloma is a common neuroimaging abnormality in Indian patients with new-onset epilepsy. Calcific transformation of cysticercus granuloma is frequently associated with seizure recurrence. We evaluated predictors of lesion calcification in patients with solitary cysticercus granuloma and new-onset seizures. One hundred twenty-two patients, with new-onset seizures and a solitary cysticercus granuloma of the brain, were enrolled. All patients were clinically and radiologically evaluated and were treated with antiepileptic drug drugs. No patient received albendazole or corticosteroids. The follow-up period was of 1 year. Follow-up computed tomography was performed after 3 and 6 months. In 68 (54.8%) patients, solitary cysticercus granuloma had transformed into a calcified lesion. On logistic regression analysis, moderate-to-severe edema was a significant factor that predicted calcific transformation of the cysticercus granuloma (odds ratio: 3.325; 95% confidence interval: 1.502-7.362). During 1 year of follow-up, 19 (15.6%) patients experienced seizure recurrence. In 16 patients with seizure recurrence, cysticercus granuloma had transformed in to a calcified lesion. In conclusion, in solitary cysticercus granuloma, calcification of the lesion can be predicted if larger amount of perilesional edema is present. Calcification of the granuloma significantly predicts seizure recurrence.

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“…According to Chernov et al [54] lactate-producing neoplasms are associated with more prominent reduction of the relative NAA content in the surrounding cerebral tissue, independently on the presence or absence of any other factor. According to Fan et al [55] both a high Cho peak and elevated Cho/Cr ratio were found in the peritumoral regions of high-grade gliomas, but not in metastases.…”

Section: Future Perspectivesmentioning

confidence: 99%

Clinical decision support systems for brain tumor characterization using advanced magnetic resonance imaging techniques

Tsolaki

Kousi

Svolos

et al. 2014

WJR

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In recent years, advanced magnetic resonance imaging (MRI) techniques, such as magnetic resonance spectroscopy, diffusion weighted imaging, diffusion tensor imaging and perfusion weighted imaging have been used in order to resolve demanding diagnostic problems such as brain tumor characterization and grading, as these techniques offer a more detailed and noninvasive evaluation of the area under study. In the last decade a great effort has been made to import and utilize intelligent systems in the so-called clinical decision support systems (CDSS) for automatic processing, classification, evaluation and representation of MRI data in order for advanced MRI techniques to become a part of the clinical routine, since the amount of data from the aforementioned techniques has gradually increased. Hence, the purpose of the current review article is two-fold. The first is to review and evaluate the progress that has been made towards the utilization of CDSS based on data from advanced MRI techniques. The second is to analyze and propose the future work that has to be done, based on the existing problems and challenges, especially taking into account the new imaging techniques and parameters that can be introduced into intelligent systems to significantly improve their diagnostic specificity and clinical application.

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Proton MRS of the peritumoral brain

Cited by 41 publications

References 17 publications

Metabolic Findings on 3T 1H-MR Spectroscopy in Peritumoral Brain Edema

Metabolic Findings on 3T 1H-MR Spectroscopy in Peritumoral Brain Edema

Predictors of Lesion Calcification in Patients with Solitary Cysticercus Granuloma and New-Onset Seizures

Clinical decision support systems for brain tumor characterization using advanced magnetic resonance imaging techniques

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