Proton MRS in Beh�et?s disease with and without neurological findings

Baysal, Tamer; Özışık, Handan Işın; Karlidağ, Rıfat; Saraç, Kaya; Baysal, Özlem; Duşak, Abdurrahim; Haznecî, Ersoy; Özcan, Cemal

doi:10.1007/s00234-003-1052-7

Cited by 19 publications

(33 citation statements)

References 21 publications

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“…Also, our study detected a decrease in the size of the CC in proportion to the duration of the disease in Behçet's patients with brains that were macroscopically normal in appearance. Similar to the results of Baysal et al (2003,2005), our results may indicate that the microstructural changes in the CC could be due to vasculitic injury to interhemispheric, transcallosal fiber tracks.…”

Section: Discussionsupporting

confidence: 92%

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Detecting the Shape Differences of the Corpus Callosum in Behçet's Disease by Statistical Shape Analysis

Çolak

Ercan

Doğan

et al. 2011

The Anatomical Record

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The aim of this study was to assess the shape differences of the corpus callosum (CC) in patients with Behçet's disease using statistical shape analysis (SSA). Additionally, an attempt was made to investigate the changes in CC size according to disease duration. Twenty-five adults with clinically diagnosed Behçet's disease and 25 age-and gendermatched controls were examined by high-resolution structural magnetic resonance imaging. The data obtained from the coordinate of landmarks were analyzed with Euclidean distance matrix analysis and a thin-plate spline analysis. SSA and growth curve models were performed to investigate group differences and to fit the curves. A significant difference was determined between CC shape of Behçet patients and controls (P ¼ 0.006). Based on the analysis, a decrease occurred in the CC size of the Behçet patients as the duration of disease increased. Maximum deformations were determined in the landmarks of interior notch of the splenium, inferior tip of the splenium, posterior-most point of the CC, and topmost point of the CC. Similarly, the landmark of anterior-most point of the CC was identified as having the minimum deformation. Behçet patients had significantly different CC shapes from control subjects. The results suggest that SSA is a promising tool for distinguishing Behçet patients from normal subjects, and that it can give useful information to assist clinicians. Additionally, SSA might be applied to detect shape differences in anatomical structures that are affected by a broad range of neurological diseases. Anat Rec, 294:870-874, 2011. V V C 2011 Wiley-Liss, Inc.

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Section: Discussionsupporting

confidence: 92%

“…Baysal et al (2003,2005) determined differences in the apparent diffusion coefficient values of Behçet patients by means of diffusion‐weighted MR imaging and magnetic resonance spectroscopy in the brain regions when structural changes are absent. According to their findings, they identified microstructural changes caused by vasculitis.…”

Section: Discussionmentioning

confidence: 99%

Detecting the Shape Differences of the Corpus Callosum in Behçet's Disease by Statistical Shape Analysis

Çolak

Ercan

Doğan

et al. 2011

The Anatomical Record

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“…Local inflammation plays a role in numerous neurologic conditions and processes, such as stroke/ischemia, trauma, epilepsy, multiple sclerosis, and Alzheimer's disease (4). Elevated cerebral levels of choline are a common finding of 1 H‐MRS in patients with these conditions (9, 21–23). However, the studies mentioned above were not aimed at finding an association between levels of inflammation and neurochemical abnormalities.…”

Section: Discussionmentioning

confidence: 99%

Brain involvement in rheumatoid arthritis: A magnetic resonance spectroscopy study

Emmer¹,

Bijl²,

Huizinga³

et al. 2009

Arthritis & Rheumatism

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Objective. Tumor necrosis factor ␣ was recently implicated as an important mediator of communication between the peripheral and cerebral immune systems in an animal model of chronic inflammation. The purpose of this study was to examine by proton magnetic resonance spectroscopy ( 1 H-MRS) the influence of inflammation on cerebral metabolism in patients with rheumatoid arthritis (RA).Methods. Single-voxel 1 H-MRS of the centrum semiovale was performed on 35 RA patients (6 men and 29 women; mean ؎ SD age 51.8 ؎ 14.6 years) and 28 healthy age-and sex-matched control subjects (9 men and 19 women; mean ؎ SD age 50.2 ؎ 10.4 years). None of the study subjects had any neurologic signs or symptoms. Clinical markers of disease activity were correlated with the 1 H-MRS findings.Results. Patients with active RA, as reflected by an elevated erythrocyte sedimentation rate (ESR), had a significantly higher ratio of choline to creatine and a significantly lower ratio of N-acetylaspartate to choline than did patients with inactive RA, as reflected by a normal ESR. Moreover, the ratios of choline to creatine and NAA to choline were significantly correlated with the ESR after correction for age, sex, smoking status, handedness, alcohol consumption, medication use, and disease duration. Medication use had no additional effect on these associations. Conclusion.Our data show that systemic inflammation in RA is associated with metabolic changes in the brain.

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“…The absence of cytotoxic edema on DWI and no lactic acid peak in the MRS provide further evidence that tissue necrosis as a consequence of inXammation or vasculitic ischemia did not occur within the cortical lesion whereas an inXammatory process is also supported by the Wnding of a reduced NAA/ Cr ratio and an elevation of the Cho peak as signs of neuronal damage and myelin degradation, respectively. These MRS data must be interpreted with caution because we compared peaks and ratios of a cortical lesion with those obtained from non-cortical areas of the brain in previous publications [21,22]. The spectrum obtained from the lesion by centering a voxel on the ROI in the right anterior cingulate cortex on an axial FLAIR scan (inset) demonstrates normal N-acetyl aspartate (NAA) and creatine (Cr) peaks, elevated level of choline (Cho), and absence of a lactic acid peak, which is consistent with inXammation In conclusion, we were able to document a transient cortical inXammatory focus in a patient with Behçet's syndrome who presented with a mucocutaneous exacerbation and non-structural headache, which is deWned as frontal, bilateral paroxysmal throbbing pain of moderate severity in the absence of neurologic signs [23].…”

Section: Discussionmentioning

confidence: 99%

Transient involvement of the cerebral cortex in a flare of Behçet’s syndrome

et al. 2010

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We describe a flare of Behçet's syndrome in a 42-year-old man who presented with florid mucocutaneous manifestations, headache and vomiting, but without meningeal or neurologic signs. A single, non-enhancing cortical lesion was found in the frontal lobe by computed tomography and magnetic resonance (MR) imaging studies. Diffusion-weighted analysis and MR spectroscopy were consistent with focal inflammation. The patient improved with colchicine, and after 5 months, a repeat MR scan demonstrated resolution of the inflammatory changes suggesting that involvement of the cerebral cortex may be a self-limiting phenomenon, distinct from other more frequent and destructive parenchymal manifestations of neuro-Behçet's disease.

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Proton MRS in Beh�et?s disease with and without neurological findings

Cited by 19 publications

References 21 publications

Detecting the Shape Differences of the Corpus Callosum in Behçet's Disease by Statistical Shape Analysis

Detecting the Shape Differences of the Corpus Callosum in Behçet's Disease by Statistical Shape Analysis

Brain involvement in rheumatoid arthritis: A magnetic resonance spectroscopy study

Transient involvement of the cerebral cortex in a flare of Behçet’s syndrome

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