Proton MR spectroscopy of the lumbar spine in patients with glycogen storage disease type Ib

Scherer, A.; Wittsack, Hans‐Jörg; Engelbrecht, V.; Schwarz, Štefan; May, Philip; Poll, L. W.; Koch, Jens‐Albrecht; Wendel, U.; Mödder, Ulrich

doi:10.1002/jmri.10017

Cited by 10 publications

(3 citation statements)

References 20 publications

(27 reference statements)

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“…Recently, a number of works have been devoted to age‐, sex‐, and composition‐differences of bone marrow specified by magnetic resonance spectroscopy (MRS) in healthy subjects (12, 13) as well as to comparison of normal and pathological bone marrow (14–17). It has been shown that the W/F ratio in healthy vertebral bone marrow varies from 9.0 (11–20 years old) to 0.1 (>60 years old) (12–16). For subjects between 30–60 years old W/F ranges within 2–0.5.…”

Section: Discussionmentioning

confidence: 99%

Magnetic resonance investigation of bone marrow following priming and stem cell mobilization

Chabanova

Johnsen

Knudsen

et al. 2006

Magnetic Resonance Imaging

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Purpose: To evaluate application of MRI and magnetic resonance spectroscopy (MRS) to monitor bone marrow cellularity during pretransplant priming with chemotherapy and hematopoietic growth factor (HGF) administration. Materials and Methods:A total of 10 lymphoma and myeloma patients, in remission following induction therapy and considered eligible for high-dose therapy and autologous stem cell transplantation, were included in the study. MR investigation was scheduled four times: at study entry, and one, two, and four weeks following priming. Priming with cyclophosphamide and recombinant human granulocyte colony-stimulating factor (rhG-CSF) started the day after study entry. MR parameters studied in a region of interest were as follows: bone marrow intensity on shorttime inversion-recovery (STIR) turbo spin-echo (TSE; thus STIRTSE) and on T1-weighted TSE (T1TSE) images, T2 value for fat component, T2 value for water component, water/fat ratio (W/F), T1 value for fat component, and T1 value for water component. Results:The results did not support the hypothesis that hematopoietic expansion quantitated and monitored by MR correlates to the level of mobilized progenitor cells. Conclusion:The results indicate that release of stem cells is a more complex phenomenon than hematopoietic expansion and reduction of fat tissue in bone marrow.

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Section: Discussionmentioning

confidence: 99%

Magnetic resonance investigation of bone marrow following priming and stem cell mobilization

Chabanova

Johnsen

Knudsen

et al. 2006

Magnetic Resonance Imaging

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“…Spectra were manually phase-corrected. The expected resonances of the lipid peaks (Table 1) were determined from published human BM spectra (28)(29)(30)(31). Soft constraints of 6 0.05 ppm were imposed around the resonances to allow some flexibility to the fitting algorithm.…”

Section: Mr Spectroscopymentioning

confidence: 99%

MRI Measurement of Bone Marrow Cellularity for Radiation Dosimetry

Pichardo

Milner²,

Bolch³

2011

J Nucl Med

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The current gold standard for measuring marrow cellularity is the bone marrow (BM) biopsy of the iliac crest. This measure is not predictive of total marrow cellularity, because the biopsy volume is typically small and fat fraction varies across the skeleton. MRI and localized MR spectroscopy have been demonstrated as noninvasive means for measuring BM cellularity in patients. The accuracy of these methods has been well established in phantom studies and in the determination of in vivo hepatic fat fractions but not for in vivo measurement of BM cellularity. Methods: Spoiled gradient-echo in vivo images of the femur, humerus, upper spine, and lower spine were acquired for 2 dogs using a clinical 3-T MRI scanner. Single-peak iterative decomposition of water and fat with echo asymmetry and least squares (SP-IDEAL) was used to derive BM fat fractions. Stimulated-echo acquisition mode spectra were acquired in order to perform multipeak IDEAL with precalibration (MP-IDEAL). In vivo accuracy was validated by comparison with histology measurements. Histologic fat fractions were derived from adipocyte segmentation. Results: Bland-Altman plots demonstrated excellent agreement between SP-IDEAL and histology, with a mean difference of 20.52% cellularity and most differences within 62% cellularity, but agreement between MP-IDEAL and histology was not as good (mean difference, 27% cellularity, and differences between 5% and 220%). Conclusion: Adipocyte segmentation of histology slides provides a measure of volumetric fat fraction (i.e., adipocyte volume fraction [AVF]) and not chemical fat fraction, because fat fraction measured from histology is invariant to the relative abundances of lipid chemical species. In contrast, MP-IDEAL provides a measure of chemical fat fraction, thus explaining the poor agreement of this method with histology. SP-IDEAL measures the relative abundance of methylene lipids, and this measure is shown to be equivalent to AVF. AVF provides the appropriate parameter to account for patient-specific cellularity in BM mass predictive equations and is consistent with current micro-CTbased models of skeletal dosimetry.

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“…The cellularity of bone marrow can be calculated from the most dominant peaks in the proton spectrum of marrow from methylene and water peaks (14). Proton MRS showed a good correlation between the cellularity and water signal intensity compared to bone marrow biopsy (14,40,41). These studies suggest that MRS can be used to evaluate the bone marrow cellularity or biochemical composition in vivo in different disease entities.…”

Section: Discussionmentioning

confidence: 82%

Proton MR spectroscopy of the femoral head—Evaluation of patients at risk for avascular necrosis

Hou

Shih

Liu

et al. 2006

Magnetic Resonance Imaging

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Purpose: To detect alteration of the fatty component by measuring the in vivo lipid and water content of normal-looking femoral heads of patients with and without risk for avascular necrosis (AVN) by using proton MR spectroscopy (MRS). Materials and Methods:Marrow composition was measured by proton MRS (TR/TE ϭ 5000/20 msec) in a sample volume placed in the epiphysis of the intact femoral heads of patients with unilateral osteonecrosis of the hip (group 1, N ϭ 61, then excluding the post-traumatic or steroid user, final N ϭ 45) and age-matched controls (group 2, N ϭ 49). Three response variables were derived from MRS: the lipid linewidth (LW), water LW, and lipid/water ratio. Results:Of the three variables, the lipid and water LWs differed significantly between groups (P Ͻ 0.001 and P ϭ 0.05, respectively; t-test). The lipid/water ratio had borderline significance (P ϭ 0.06). The three variables differed significantly between groups when multivariate regression (P Ͻ 0.0001) was analyzed; and age and sex had no significant effect on the three dependent variables. Conclusion:Proton MRS can depict alteration in the lipid and water composition of normal-looking femoral heads with and without AVN on the contralateral hip. Proton MRS may be a potential tool for investigating of the femoral head component in vivo and predicting the risk for development of AVN.

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Proton MR spectroscopy of the lumbar spine in patients with glycogen storage disease type Ib

Cited by 10 publications

References 20 publications

Magnetic resonance investigation of bone marrow following priming and stem cell mobilization

Magnetic resonance investigation of bone marrow following priming and stem cell mobilization

MRI Measurement of Bone Marrow Cellularity for Radiation Dosimetry

Proton MR spectroscopy of the femoral head—Evaluation of patients at risk for avascular necrosis

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