Proton-mediated burst of dual-drug loaded liposomes for biofilm dispersal and bacterial killing

Wang, Da‐Yuan; Yang, Guang; Zhang, Xiaoxiao; Mei, Henny C. van der; Ren, Yijin; Busscher, Henk J.; Shi, Linqi

doi:10.1016/j.jconrel.2022.10.049

Cited by 5 publications

(2 citation statements)

References 43 publications

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“… 189 Moreover, Wang et al (2022) demonstrated that drug-loaded liposomes facilitated the significant degradation of S. aureus biofilms through proton-mediated burst action. 190 These results suggest that liposomes may serve as a promising platform for developing effective strategies for controlling biofilm formation by clinically relevant pathogens.…”

Section: Nanotechnological Approaches For Biofilm Controlmentioning

confidence: 94%

“…Additionally, Fang et al (2021) observed that cationic liposomes containing DNase I/proteinase K were able to penetrate up to 85% of the biofilm matrix and exhibited the potential to eradicate Cutibacterium acnes biofilms . Moreover, Wang et al (2022) demonstrated that drug-loaded liposomes facilitated the significant degradation of S. aureus biofilms through proton-mediated burst action . These results suggest that liposomes may serve as a promising platform for developing effective strategies for controlling biofilm formation by clinically relevant pathogens.…”

Section: Nanotechnological Approaches For Biofilm Controlmentioning

confidence: 99%

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Advances in Nanotechnology for Biofilm Inhibition

et al. 2023

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Biofilm-associated infections have emerged as a significant public health challenge due to their persistent nature and increased resistance to conventional treatment methods. The indiscriminate usage of antibiotics has made us susceptible to a range of multidrug-resistant pathogens. These pathogens show reduced susceptibility to antibiotics and increased intracellular survival. However, current methods for treating biofilms, such as smart materials and targeted drug delivery systems, have not been found effective in preventing biofilm formation. To address this challenge, nanotechnology has provided innovative solutions for preventing and treating biofilm formation by clinically relevant pathogens. Recent advances in nanotechnological strategies, including metallic nanoparticles, functionalized metallic nanoparticles, dendrimers, polymeric nanoparticles, cyclodextrin-based delivery, solid lipid nanoparticles, polymer drug conjugates, and liposomes, may provide valuable technological solutions against infectious diseases. Therefore, it is imperative to conduct a comprehensive review to summarize the recent advancements and limitations of advanced nanotechnologies. The present Review encompasses a summary of infectious agents, the mechanisms that lead to biofilm formation, and the impact of pathogens on human health. In a nutshell, this Review offers a comprehensive survey of the advanced nanotechnological solutions for managing infections. A detailed presentation has been made as to how these strategies may improve biofilm control and prevent infections. The key objective of this Review is to summarize the mechanisms, applications, and prospects of advanced nanotechnologies to provide a better understanding of their impact on biofilm formation by clinically relevant pathogens.

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Section: Nanotechnological Approaches For Biofilm Controlmentioning

confidence: 94%

Section: Nanotechnological Approaches For Biofilm Controlmentioning

confidence: 99%