1994
DOI: 10.1016/0016-5085(94)90552-5
|View full text |Cite
|
Sign up to set email alerts
|

Proton magnetic resonance spectroscopy studies on human brain Myo-inositol in hypo-osmolarity and hepatic encephalopathy

Abstract: The 1H-MR spectroscopic myo-inositol signal in the human brain predominantly reflects an osmosensitive inositol pool. It is hypothesized that its depletion in latent hepatic encephalopathy points to a disturbance of cell volume homeostasis in the brain as an early pathogenetic event. This may partly be caused by a hyperammonemia-induced glutamine accumulation in the brain.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

9
253
0
11

Year Published

1996
1996
2015
2015

Publication Types

Select...
10

Relationship

0
10

Authors

Journals

citations
Cited by 393 publications
(273 citation statements)
references
References 21 publications
9
253
0
11
Order By: Relevance
“…6 The most accepted hypothesis for this low-grade brain edema is that astrocytic accumulation of glutamine induces edema as a result of ammonia detoxification. This hypothesis is supported by experimental data showing astrocyte swelling and changes in brain organic osmolytes in models of HE, 7 and by brain proton magnetic resonance spectroscopy studies in patients with liver cirrhosis, which consistently show increases in the glutamine/glutamate signal accompanied by myoinositol depletion, 8 …”
mentioning
confidence: 66%
“…6 The most accepted hypothesis for this low-grade brain edema is that astrocytic accumulation of glutamine induces edema as a result of ammonia detoxification. This hypothesis is supported by experimental data showing astrocyte swelling and changes in brain organic osmolytes in models of HE, 7 and by brain proton magnetic resonance spectroscopy studies in patients with liver cirrhosis, which consistently show increases in the glutamine/glutamate signal accompanied by myoinositol depletion, 8 …”
mentioning
confidence: 66%
“…8 The majority of therapeutic measures currently in use are therefore directed at reducing blood Abbreviations: HE, hepatic encephalopathy; SHE, subclinical hepatic encephalopathy; ammonia levels, 9-13 mainly by diminishing enteric ammonia OA, L-ornithine-L-aspartate; GS, glutamine synthetase; NCT-A, number connection test A; PSEI, portal systemic encephalopathy index.…”
Section: Although a Slight Improvement Occurred In The Placebomentioning
confidence: 99%
“…53 MRS changes observed in HE are reversible after liver transplantation or pharmacological treatment. 35,54,55 8. Correct answer: A ICP measurement is indicated in patients of ALF who have grade 3 or 4 encephalopathy.…”
Section: Correct Answers: B C D and Ementioning
confidence: 99%