Proton magnetic resonance spectroscopy in primary and secondary progressive multiple sclerosis

Cucurella, Maria‐Gracia; Río, Jordi; Pedraza, Salvador; Montalbán, Xavier; Alonso, J. A.

doi:10.1002/(sici)1099-1492(200004)13:2<57::aid-nbm609>3.3.co;2-x

Cited by 2 publications

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“…Secondly, these data may also reflect the patients studied, many of whom are highly functioning in spite of significant EDSS values. This would also be consistent with the data of Cucurella et al, 16 who in studying patients with more advanced disease, demonstrated decreased NAA values.…”

Section: Discussionsupporting

confidence: 92%

“…13 ± 15 However, relatively few studies have examined whether such an inflammatory and gliotic profile is also seen in primary progressive (PP) disease. 2,16,17 This issue is particularly relevant since the cranial MR image of PP disease is known to have many fewer gadoliniumenhancing lesions, a lesser T1 lesion load and to demonstrate more abnormalities in the brainstem and spinal cord. 18,19 Additionally, there has been the suggestion that the pathophysiology of disease progression in PP disease is distinct from the other subtypes of MS. 20,21 Previous work, including our own, 16,22 using quantitative MR spectroscopy had suggested that PP patients demonstrate lower concentrations of NAA compared to control and RR MS.…”

Section: Introductionmentioning

confidence: 99%

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Metabolic differences between multiple sclerosis subtypes measured by quantitative MR spectroscopy

et al. 2002

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We used quantitative magnetic resonance (MR) spectroscopic imaging with T1-based image segmentation to evaluate the subtypes of multiple sclerosis (MS) (eight patients each group of relapsing-remitting [RR], secondary progressive [SP] and primary progressive [PP]). There was no significant difference in age between the PP group with the RP, SP or control group. We found that the metabolite ratio of choline/NA from the periventricular white matter region was not significantly different between the RR and SP groups. Using an ANOVA, the ratios of periventricular choline/NA or creatine/NA of these combined groups were significantly higher than the PP and control groups. Quantification of these data suggest that the major cause of the elevation of these parameters is due to an increase in choline and creatine in the RR group while NA is decreased in the SP group. Thus, early PP disease appears to be relatively intact with respect to neuronal loss.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Metabolic differences between multiple sclerosis subtypes measured by quantitative MR spectroscopy

et al. 2002

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Characterisation of tissue-type metabolic content in secondary progressive multiple sclerosis: a magnetic resonance spectroscopic imaging study

et al. 2018

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Proton magnetic resonance spectroscopy yields metabolic information and has proved to be a useful addition to structural imaging in neurological diseases. We applied short-echo time Spectroscopic Imaging in a cohort of 42 patients with secondary progressive multiple sclerosis (SPMS). Linear modelling with respect to brain tissue type yielded metabolite levels that were significantly different in white matter lesions compared with normal-appearing white matter, suggestive of higher myelin turnover (higher choline), higher metabolic rate (higher creatine) and increased glial activity (higher myo-inositol) within the lesions. These findings suggest that the lesions have ongoing cellular activity that is not consistent with the usual assumption of ‘chronic’ lesions in SPMS, and may represent a target for repair therapies.

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Proton magnetic resonance spectroscopy in primary and secondary progressive multiple sclerosis

Cited by 2 publications

References 0 publications

Metabolic differences between multiple sclerosis subtypes measured by quantitative MR spectroscopy

Metabolic differences between multiple sclerosis subtypes measured by quantitative MR spectroscopy

Characterisation of tissue-type metabolic content in secondary progressive multiple sclerosis: a magnetic resonance spectroscopic imaging study

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