Proton magnetic resonance spectroscopy and its diagnostically important metabolites in the brain

Bittšanský, Michal; Výbohová, Desanka; Dobrota, Dušan

doi:10.4149/gpb_2012_007

Cited by 23 publications

(19 citation statements)

References 61 publications

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“…A purely physical explanations for increasing MI levels, like an increased cell density [26] can be mostly excluded since Cre concentrations remained unchanged. The low MI and Cre concentration in the tumor compared to the control tissue are in accordance with previous MRS studies [21–25,36]. Since other metabolites like Choline and N-acetylaspartate did also not show significant changes or relations to overall survival in a previous study [8], we will not further discuss these metabolites in this publication (further metabolite data for the CCNU/VM26 cohort can be found in S2 Table).…”

Section: Discussionsupporting

confidence: 84%

Myoinositol as a Biomarker in Recurrent Glioblastoma Treated with Bevacizumab: A 1H-Magnetic Resonance Spectroscopy Study

et al. 2016

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BackgroundAntiangiogenic treatment of glioblastomas with Bevacizumab lacks predictive markers. Myoinositol (MI) is an organic osmolyte, with intracellular concentration changes depending on the extracellular osmolality. Since Bevacizumab markedly reduces tumor edema and influences the tumor microenvironment, we investigated whether the MI concentration in the tumor changes during therapy.MethodsWe used 1H-magnetic resonance spectroscopy to measure the MI concentrations in the tumor and contralateral control tissue of 39 prospectively recruited patients with recurrent glioblastomas before and 8–12 weeks after starting therapy. 30 patients received Bevacizumab and 9 patients were treated with CCNU/VM26 as control. We performed a survival analysis to evaluate MI as a predictive biomarker for Bevacizumab therapy.ResultsMI concentrations increased significantly during Bevacizumab therapy in tumor (p < .001) and control tissue (p = .001), but not during CCNU/VM26 treatment. For the Bevacizumab cohort, higher MI concentrations in the control tissue at baseline (p = .021) and higher differences between control and tumor tissue (delta MI, p = .011) were associated with longer survival. A Kaplan-Meier analysis showed a median OS of 164 days for patients with a deltaMI < 1,817 mmol/l and 275 days for patients with a deltaMI > 1,817 mmol/l. No differences were observed for the relative changes or the post treatment concentrations. Additionally calculated creatine concentrations showed no differences in between subgroups or between pre and post treatment measurements.ConclusionOur data suggest that recurrent glioblastoma shows a strong metabolic reaction to Bevacizumab. Further, our results support the hypothesis that MI might be a marker for early tumor cell invasion. Pre-therapeutic MI concentrations are predictive of overall survival in patients with recurrent glioblastoma treated with Bevacizumab.

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Section: Discussionsupporting

confidence: 84%

Myoinositol as a Biomarker in Recurrent Glioblastoma Treated with Bevacizumab: A 1H-Magnetic Resonance Spectroscopy Study

et al. 2016

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“…These compounds are precursors of membrane phospholipids phosphatidylcholine and sphingomyelin (42). Thus, lower GPC+PC indicates potential for decreased phospholipid synthesis and possibly myelination.…”

Section: Discussionmentioning

confidence: 99%

Differential Effects of Intrauterine Growth Restriction on the Regional Neurochemical Profile of the Developing Rat Brain

et al. 2015

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Background Intrauterine growth restricted (IUGR) infants are at increased risk for neurodevelopmental deficits that suggest the hippocampus and cerebral cortex may be particularly vulnerable. Objective Evaluate regional neurochemical profiles in IUGR and normally grown (NG) 7-day old rat pups using in vivo 1H magnetic resonance (MR) spectroscopy at 9.4T. Methods IUGR was induced via bilateral uterine artery ligation at gestational day 19 in pregnant Sprague Dawley dams. MR spectra were obtained from the cerebral cortex, hippocampus and striatum at P7 in IUGR (N=12) and NG (N=13) rats. Results In the cortex, IUGR resulted in lower concentrations of phosphocreatine, glutathione, taurine, total choline, total creatine (P<0.01) and [glutamate]/[glutamine] ratio (P <0.05). Lower taurine concentrations were observed in the hippocampus (P<0.01) and striatum (P <0.05). Conclusion IUGR differentially affects the neurochemical profile of the P7 rat brain regions. Persistent neurochemical changes may lead to cortex-based long-term neurodevelopmental deficits in human IUGR infants.

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“…These conditions are usually inherited in one of several straightforward patterns, depending on the gene involved. 6 Many other disorders are caused by a combination of the effects of multiple genes or by interactions between genes and the environment (multifactorial diseases). Such disorders are more difficult to analyze because their genetic causes are often unclear and they do not follow the classic patterns of inheritance.…”

Section: Basic Principles Of Genetic Conditionsmentioning

confidence: 99%

“…2 For example, structural magnetic resonance imaging (MRI) reveals the brain's macroscopic structure, functional MRI is used to study the networks underlying cognitive operations, 3 diffusion-weighted imaging and diffusion tensor imaging are used to study microstructure variance in white matter fiber tracts, 4 and magnetic resonance spectroscopy (MRS) is used to measure brain metabolism. 5,6 In addition, a pattern recognition approach based on MRI findings is usually performed to improve accuracy of neuroimaging. 7 Regarding the report of an MRI examination, neuroradiologists usually present difficulties in suggesting a list of possible diagnoses to the pediatric neurologist or geneticist, even when the MRI findings are clearly abnormal.…”

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confidence: 99%

The Basis of Inborn Errors of Metabolism for Neuroradiologists

Vairo

Vedolin

2011

Topics in Magnetic Resonance Imaging

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Although relatively common together, inborn errors of metabolism (IEM) are individually rare, which makes difficult for most neuroradiologists to accumulate significant experience on these conditions. To facilitate the diagnostic approach, several schemes based on clinical, biochemical, genetic, and neuroimaging criteria have been proposed. Neuroimaging techniques have a great potential to improve diagnostic accuracy in as well as follow-up and management of the patients with an IEM. This article aimed to provide a nonexhaustive review of some basic information related to genetic conditions such as pattern of inheritance, penetrance, variable expressivity, genotype, phenotype and to provide information on how to classify, investigate, diagnose, and treat IEM besides highlighting some findings that would aid neuroradiologists to improve the diagnostic accuracy of imaging techniques, particularly magnetic resonance imaging.

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Proton magnetic resonance spectroscopy and its diagnostically important metabolites in the brain

Cited by 23 publications

References 61 publications

Myoinositol as a Biomarker in Recurrent Glioblastoma Treated with Bevacizumab: A 1H-Magnetic Resonance Spectroscopy Study

Myoinositol as a Biomarker in Recurrent Glioblastoma Treated with Bevacizumab: A 1H-Magnetic Resonance Spectroscopy Study

Differential Effects of Intrauterine Growth Restriction on the Regional Neurochemical Profile of the Developing Rat Brain

The Basis of Inborn Errors of Metabolism for Neuroradiologists

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