Proton magnetic resonance spectroscopic findings of cerebral fat embolism induced by triolein emulsion in cats

Abstract

Cerebral fat embolism induced by a triolein emulsion resulted in no significant change in the major metabolites of the brain in the acute stage, except for an elevated lipid/Cr ratio, which suggests the absence of any significant hypoxic-ischemic changes in the lesions embolized using a fat emulsion.

The Minimum Percentage of Triolein Emulsion for Studying Cerebral Vascular Permeability with Least Brain Edema

“…Thus, the dosage of triolein emulsion required to increase vascular permeability while minimizing interstitial edema should be optimized. In previous studies, the amount of triolein emulsion (0.05-0.2 mL triolein in 20 mL saline) administered have varied widely (6-8), and dosages were not optimized. Kim et al (9) reported that the proper dosage of triolein emulsion required to increase vascular permeability with minimal edema appears to be approximately 3 mL/kg of triolein in a cat model.…”

Triolein emulsion enhances temozolomide brain delivery: an experimental study in rats

“…Thus, the development of cerebral fat embolisms depends on the morphology of the embolized fat and the size of the fat particles. The increased vasogenic edema induced by triolein emulsion is reversible and does not cause any significant histological changes, hemodynamic occlusive appearance, or metabolic differences in the brain (Kim et al., 2004 , 2006 ; Baik et al., 2008 ).…”