Proton Irradiation Augments the Suppression of Tumor Progression Observed with Advanced Age

Beheshti, Afshin; Peluso, Michael J.; Lamont, Clare; Hahnfeldt, Philip; Hlatky, Lynn

doi:10.1667/rr13538.1

Cited by 12 publications

(20 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…From these terms, we observed several key pathways, including mitotic and cell cycle pathways, cancer-related pathways, hypoxia-related pathways, interferon pathways, and pathways related to radiation impact on cells ( Figure 6A). Cell cycle pathways [57], hypoxia [58], interferon dysregulation [59], and cancer [60][61][62] have all been observed in previous research studies as dysregulated due to spaceflight.…”

Section: Gsea C2: Curated Dataset Resultsmentioning

confidence: 66%

NASA GeneLab Platform Utilized for Biological Response to Space Radiation in Animal Models

McDonald¹,

Stainforth

Cahill

et al. 2020

Cancers

Self Cite

View full text Add to dashboard Cite

Background: Ionizing radiation from galactic cosmic rays (GCR) is one of the major risk factors that will impact the health of astronauts on extended missions outside the protective effects of the Earth’s magnetic field. The NASA GeneLab project has detailed information on radiation exposure using animal models with curated dosimetry information for spaceflight experiments. Methods: We analyzed multiple GeneLab omics datasets associated with both ground-based and spaceflight radiation studies that included in vivo and in vitro approaches. A range of ions from protons to iron particles with doses from 0.1 to 1.0 Gy for ground studies, as well as samples flown in low Earth orbit (LEO) with total doses of 1.0 mGy to 30 mGy, were utilized. Results: From this analysis, we were able to identify distinct biological signatures associating specific ions with specific biological responses due to radiation exposure in space. For example, we discovered changes in mitochondrial function, ribosomal assembly, and immune pathways as a function of dose. Conclusions: We provided a summary of how the GeneLab’s rich database of omics experiments with animal models can be used to generate novel hypotheses to better understand human health risks from GCR exposures.

show abstract

Section: Gsea C2: Curated Dataset Resultsmentioning

confidence: 66%

NASA GeneLab Platform Utilized for Biological Response to Space Radiation in Animal Models

McDonald¹,

Stainforth

Cahill

et al. 2020

Cancers

Self Cite

View full text Add to dashboard Cite

show abstract

“…In our recent publication, we have followed the steps above and utilized GeneLab datasets to successfully show a novel finding that CO 2 concentrations on the ISS can impact health 36 . We have also used the technique above in other studies to successfully determine the key factors driving the system being studied 45,46,47,48,49,50 . Here we will show how the results from using this protocol can be successfully used to determine the key drivers.…”

Section: Representative Resultsmentioning

confidence: 99%

Exploring the Effects of Spaceflight on Mouse Physiology using the Open Access NASA GeneLab Platform

Beheshti

Shirazi‐Fard

Choi

et al. 2019

JoVE

Self Cite

View full text Add to dashboard Cite

Performing biological experiments in space requires special accommodations and procedures to ensure that these investigations are performed effectively and efficiently. Moreover, given the infrequency of these experiments it is imperative that their impacts be maximized. The rapid advancement of omics technologies offers an opportunity to dramatically increase the volume of data produced from precious spaceflight specimens. To capitalize on this, NASA has developed the GeneLab platform to provide unrestricted access to spaceflight omics data and encourage its widespread analysis. Rodents (both rats and mice) are common model organisms used by scientists to investigate space-related biological impacts. The enclosure that house rodents during spaceflight are called Rodent Habitats (formerly Animal Enclosure Modules), and are substantially different from standard vivarium cages in their dimensions, air flow, and access to water and food. In addition, due to environmental and atmospheric conditions on the International Space Station (ISS), animals are exposed to a higher CO 2 concentration. We recently reported that mice in the Rodent Habitats experience large changes in their transcriptome irrespective of whether animals were on the ground or in space. Furthermore, these changes were consistent with a hypoxic response, potentially driven by higher CO 2 concentrations. Here we describe how a typical rodent experiment is performed in space, how omics data from these experiments can be accessed through the GeneLab platform, and how to identify key factors in this data. Using this process, any individual can make critical discoveries that could change the design of future space missions and activities.

show abstract

“…3C), largely for comparison to HZE radiation. Proton and 56 Fe-radiation experiments (28,(36)(37)(38)(39)(40)(41)(42) comprise the majority of simulated space radiation-related GeneLab datasets, with a few experiments related to 16 O (43), 12 C (44), 28 Si (45) and neutrons (46) (Fig. 3C).…”

Section: Radiation Ground Studies Currently In Genelabmentioning

confidence: 99%

NASA GeneLab Project: Bridging Space Radiation Omics with Ground Studies

et al. 2018

Self Cite

View full text Add to dashboard Cite

Accurate assessment of risks of long-term space missions is critical for human space exploration. It is essential to have a detailed understanding of the biological effects on humans living and working in deep space. Ionizing radiation from galactic cosmic rays (GCR) is a major health risk factor for astronauts on extended missions outside the protective effects of the Earth's magnetic field. Currently, there are gaps in our knowledge of the health risks associated with chronic low-dose, low-dose-rate ionizing radiation, specifically ions associated with high (H) atomic number (Z) and energy (E). The NASA GeneLab project ( https://genelab.nasa.gov/ ) aims to provide a detailed library of omics datasets associated with biological samples exposed to HZE. The GeneLab Data System (GLDS) includes datasets from both spaceflight and ground-based studies, a majority of which involve exposure to ionizing radiation. In addition to detailed information on radiation exposure for ground-based studies, GeneLab is adding detailed, curated dosimetry information for spaceflight experiments. GeneLab is the first comprehensive omics database for space-related research from which an investigator can generate hypotheses to direct future experiments, utilizing both ground and space biological radiation data. The GLDS is continually expanding as omics-related data are generated by the space life sciences community. Here we provide a brief summary of the space radiation-related data available at GeneLab.

show abstract

Proton Irradiation Augments the Suppression of Tumor Progression Observed with Advanced Age

Cited by 12 publications

References 46 publications

NASA GeneLab Platform Utilized for Biological Response to Space Radiation in Animal Models

NASA GeneLab Platform Utilized for Biological Response to Space Radiation in Animal Models

Exploring the Effects of Spaceflight on Mouse Physiology using the Open Access NASA GeneLab Platform

NASA GeneLab Project: Bridging Space Radiation Omics with Ground Studies

Contact Info

Product

Resources

About