Proton beam therapy: the next disruptive innovation in healthcare?

Swisher‐McClure, Samuel; Hahn, Stephen M.; Bekelman, Justin E.

doi:10.1136/postgradmedj-2014-132935

Cited by 6 publications

(9 citation statements)

References 14 publications

(11 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…RBE is clinically applied across patient populations despite significant variabilities based on tumor type, tissue origin or genetic background 7 . Moreover, limited knowledge of molecular and biological responses to particle compared to X-ray radiation 8 has impeded the development of particle-specific therapeutic and combinatorial strategies.…”

Section: Introductionmentioning

confidence: 99%

Differential transcriptome response to proton versus X-ray radiation reveals novel candidate targets for combinatorial PT therapy in lymphoma

Sertorio

Nowrouzi²,

Akbarpour³

et al. 2021

Radiotherapy and Oncology

View full text Add to dashboard Cite

This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

show abstract

Section: Introductionmentioning

confidence: 99%

Differential transcriptome response to proton versus X-ray radiation reveals novel candidate targets for combinatorial PT therapy in lymphoma

Sertorio

Nowrouzi²,

Akbarpour³

et al. 2021

Radiotherapy and Oncology

View full text Add to dashboard Cite

show abstract

“…The evidence to support proton beam therapy in terms of outcomes and cost is limited (Moriarty, Borah, Foote, Pulido, & Shah, 2015). Construction of a proton therapy center is costly, ranging from $25 million to more than $200 million, depending on the size of the facility (Swisher-McClure et al, 2015). The costs of treatment are about two to three times greater than photon-based radiation treatments.…”

Section: Challengesmentioning

confidence: 99%

“…The costs of treatment are about two to three times greater than photon-based radiation treatments. In addition, because of the cost of constructing a facility, these centers are only available in select locations, adding to the financial burden for patients and their families because receiving proton beam therapy may involve travel, housing, and potential lost wages (Swisher-McClure et al, 2015).…”

Section: Challengesmentioning

confidence: 99%

“…The benefit of this is that the proton beam stops within the patient's tumor region, and the radiation does not extend to normal tissue beyond the tumor. This allows for radiation absorption to deep tumor targets with less scatter of radiation to normal surrounding tissues and the possible safe escalation of radiation doses to enhance tumor control (Daw & Mahajan, 2013;Swisher-McClure, Hahn, & Bekelman, 2015).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Proton Beam Therapy for Pediatric Malignancies

Doyle-Lindrud

2015

CJON

View full text Add to dashboard Cite

Although major advances have been made in radiation techniques, concerns still exist about the treatment-related acute and long-term side effects. This issue is most notable in the pediatric population because of developing organs and tissues combined with longer life expectancies. Proton beam therapy has the advantage of a reduced dose of radiation with less scatter to normal tissue, which may lead to fewer adverse side effects. AT A GLANCE: Many pediatric patients with cancer receive radiation therapy.Radiation treatments can cause significant acute and long-term side effects.Proton beam therapy reduces radiation scatter to normal tissues and may decrease acute and late toxicities.

show abstract

“…Proton therapy (PT) has many advantages comparing to conventional techniques such as photon therapy. PT can reduce low and intermediate radiation dose to normal tissues, which improves the outcomes of patients with cancer by reducing treatment-related toxicities and/or allowing a higher safe radiation doses to enhance tumor control rates ( 6 ). The effectiveness of PT was shown in many systematic reviews in different types of cancers [e.g., head and neck cancer ( 7 ), breast cancer ( 8 ), prostate cancer ( 9 ), rectal cancer ( 10 ), nasopharyngeal cancer ( 11 ), gastrointestinal malignancies ( 12 ), chordoma ( 13 ), and gliomas ( 14 ) and different age groups ( 15 , 16 ).…”

Section: Introductionmentioning

confidence: 99%

Inequality in Accessibility of Proton Therapy for Cancers and Its Economic Determinants: A Cross-Sectional Study

et al. 2022

View full text Add to dashboard Cite

BackgroundCancer is a leading cause of death in the world, and the estimated new cancer cases were 19 million and the estimated cancer deaths were around 10 million worldwide in 2020. Proton therapy (PT) is a promising treatment for cancers; however, only few patients with cancer received PT due to limited number of PT centers worldwide, especially in low- and middle-income countries.Methods and ResultsCross-sectional country level data were collected from publicly available information. Lorenz curves and Gini coefficient were used to assess the inequality in accessing to PT, and zero-inflated Poisson models were used to investigate the determinants of number of PT facilities in each country. The Gini coefficients were 0.96 for PT centers and 0.96 for PT chambers, which indicated high level of inequality. Total GDP had a significant impact on whether a country had a practical PT center, whereas total GDP and GDP per capita had significant impacts on the number of PT centers.ConclusionExtremely high inequality exists in accessibility of PT centers among all countries in the world. Economic development was the most important factor determining the adoption of PT; thus, with the growth in global economics, more PT centers can be expected in near future.

show abstract

Proton beam therapy: the next disruptive innovation in healthcare?

Cited by 6 publications

References 14 publications

Differential transcriptome response to proton versus X-ray radiation reveals novel candidate targets for combinatorial PT therapy in lymphoma

Differential transcriptome response to proton versus X-ray radiation reveals novel candidate targets for combinatorial PT therapy in lymphoma

Proton Beam Therapy for Pediatric Malignancies

Inequality in Accessibility of Proton Therapy for Cancers and Its Economic Determinants: A Cross-Sectional Study

Contact Info

Product

Resources

About