Abstract:Purpose
Periorbital tumor location presents a significant challenge with 3-dimensional conformal radiation therapy or intensity modulated radiation therapy due to high tumor dose needed in the setting of close proximity to orbital structures with lower tolerance. Proton beam therapy (PBT) is felt to be an effective modality in such cases due to its sharp dose gradient.
Materials and Methods
We reviewed our institutional PBT r… Show more
“…Given the extensive vascular system, sparse connective tissue and particularly thin skin, basal cell carcinoma can easily penetrate tissues and spread to the surrounding areas, complicating the treatment process. Invasion usually requires orbital exenteration, as noted by N.J. Damico et al [5]. There are several treatment options for basal cell carcinoma.…”
The relevance of this study lies in the development and implementation of an effective method of the Tenzel flap for the reconstruction of full-layer defects of the lower eyelid after resection of basal cell carcinoma. The purpose of this scientific study was to reconstruct the lower eyelid after resection of basal cell carcinoma using the Tenzel flap method and to investigate its effectiveness and results. The main feature of the surgical procedure was the use of a semicircular rotary Tenzel flap to repair moderate eyelid defects. This method involved the formation of a flap that starts from the outer corner of the eye, then moves up and along the temple, without crossing the outer edge of the eyebrow. After that, lateral cantolysis was used. The uniqueness lies in the ability to effectively correct moderate eyelid defects in one step, which simplifies the surgical process and minimises trauma to the patient. A significant condition in this procedure is the preservation of the tarsal plate on both sides of the excision, which allows preserving the structural integrity of the eyelid. Furthermore, this modification involves the use of the chondrocytic part of the nasal septum as a substitute and shows the effectiveness of this approach in the reconstruction of the eyelid after removal of basal cell carcinoma. Thus, the specific feature of the described surgical intervention is its effectiveness for moderate eyelid defects and the possibility of using modified methods of substitutes for complex defects. Given the results of the study, this modified method may become a major step in the treatment of patients with basal cell carcinoma, contributing to satisfactory cosmetic and functional results
“…Given the extensive vascular system, sparse connective tissue and particularly thin skin, basal cell carcinoma can easily penetrate tissues and spread to the surrounding areas, complicating the treatment process. Invasion usually requires orbital exenteration, as noted by N.J. Damico et al [5]. There are several treatment options for basal cell carcinoma.…”
The relevance of this study lies in the development and implementation of an effective method of the Tenzel flap for the reconstruction of full-layer defects of the lower eyelid after resection of basal cell carcinoma. The purpose of this scientific study was to reconstruct the lower eyelid after resection of basal cell carcinoma using the Tenzel flap method and to investigate its effectiveness and results. The main feature of the surgical procedure was the use of a semicircular rotary Tenzel flap to repair moderate eyelid defects. This method involved the formation of a flap that starts from the outer corner of the eye, then moves up and along the temple, without crossing the outer edge of the eyebrow. After that, lateral cantolysis was used. The uniqueness lies in the ability to effectively correct moderate eyelid defects in one step, which simplifies the surgical process and minimises trauma to the patient. A significant condition in this procedure is the preservation of the tarsal plate on both sides of the excision, which allows preserving the structural integrity of the eyelid. Furthermore, this modification involves the use of the chondrocytic part of the nasal septum as a substitute and shows the effectiveness of this approach in the reconstruction of the eyelid after removal of basal cell carcinoma. Thus, the specific feature of the described surgical intervention is its effectiveness for moderate eyelid defects and the possibility of using modified methods of substitutes for complex defects. Given the results of the study, this modified method may become a major step in the treatment of patients with basal cell carcinoma, contributing to satisfactory cosmetic and functional results
Treatment of localized cancer with protons therapy (PT) seems an appealing alternative to photons. PT has been available for decades and has unique dose distribution properties with the so-called Bragg-peak enabling protons to stop after their maximum depth is reached within millimeters. PT allows sparing of normal tissues and organs to a much greater extent than photons, even when modern photon techniques like intensity-modulated radiotherapy (IMRT) and volumetric modulated arc therapy (VMAT) are involved. Whereas IMRT and VMAT techniques have demonstrated their superiority to older 3D-conformal irradiation techniques, there is still a large gap between the theoretical advantages of PT due to its superior dose distribution and high-level clinical evidence, particularly in head and neck cancer (HNC). So far, mostly non-randomized clinical studies exist with clinical results in oropharyngeal, nasopharyngeal, sinonasal, periorbital, and salivary gland cancer. The limited broad availability of this treatment method and its unknown cost-effectiveness need to be evaluated. In this chapter, we discuss the currently available evidence of PT for HNCs and viable options to generate further evidence like the model-based approach.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.