Abstract:As the NRG GI006 and PROTECT trials seek to confirm results of the first randomized trial supporting the utility of proton beam therapy for esophageal cancer, several outstanding questions are discussed in this review. First, the applicability/extrapolation of the existing randomized trial is mentioned. This includes a potentially larger benefit of PBT at non-high-volume centers with less surgical expertise, along with the emerging use of active scanning PBT approaches that could further improve toxicity profi… Show more
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