Proton and Phosphorous MR Spectroscopy in Squamous Cell Carcinomas of the Head and Neck

Chawla, Sanjeev; Kim, Sungheon; Loevner, Laurie A.; Quon, Harry; Wang, Sumei; Mutale, Faith; Weinstein, Gregory S.; Delikatny, Edward J.; Poptani, Harish

doi:10.1016/j.acra.2009.06.001

Cited by 18 publications

(10 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…High Cho/W concentrations are indicative of an increased membrane choline phospholipid metabolism suggesting high proliferation (25). Khan et al recently studied patients with HNSCC with both 18 F-FDG PET (glucose metabolism) and 11 C-labeled choline PET (phospholipid metabolism) and observed a significant correlation between 18 F-FDG and 11 C-choline SUVs (26).…”

Section: Discussionmentioning

confidence: 99%

Tumor Metabolism and Perfusion in Head and Neck Squamous Cell Carcinoma: Pretreatment Multimodality Imaging With 1H Magnetic Resonance Spectroscopy, Dynamic Contrast-Enhanced MRI, and [18F]FDG-PET

Jansen

Schöder

Lee

et al. 2012

International Journal of Radiation Oncology*Biology*Physics

View full text Add to dashboard Cite

Purpose-To correlate proton magnetic resonance spectroscopy ( 1 H-MRS), dynamic contrastenhanced MRI (DCE-MRI) and 18 F-fluorodeoxyglucose ( 18 F-FDG) positron emission tomography (PET) in nodal metastases of patients with head and neck squamous cell carcinoma (HNSCC) for assessment of tumor biology. Additionally, pretreatment multimodality imaging (MMI) was evaluated for its efficacy in predicting short-term response to treatment.Methods and Materials-Metastatic neck nodes were imaged with 1 H-MRS, DCE-MRI and 18 F-FDG PET in 16 patients with newly diagnosed HNSCC before treatment. Short-term radiological response was evaluated at 3-4 months. The correlations between 1 H-MRS (choline concentration, Cho/W), DCE-MRI (volume transfer constant, K trans ; volume fraction of the extravascular extracellular space, v e ; and redistribution rate constant, k ep ) and 18 F-FDG PET (standard uptake value, SUV; and total lesion glycolysis, TLG) were calculated using nonparametric Spearman rank correlation. To predict the short-term response, logistic regression analysis was performed.Results-A significant positive correlation was found between Cho/W and TLG (ρ = 0.599, p = 0.031). Cho/W correlated negatively with heterogeneity measures std(v e ) (ρ = −0.691, p = 0.004) and std(k ep ) (ρ = −0.704, p = 0.003). SUVmax values correlated strongly with MRI tumor volume (ρ = 0.643, p = 0.007). Logistic regression indicated that std(K trans ) and SUVmean were significant predictors of short-term response (p < 0.07).

show abstract

Section: Discussionmentioning

confidence: 99%

Tumor Metabolism and Perfusion in Head and Neck Squamous Cell Carcinoma: Pretreatment Multimodality Imaging With 1H Magnetic Resonance Spectroscopy, Dynamic Contrast-Enhanced MRI, and [18F]FDG-PET

Jansen

Schöder

Lee

et al. 2012

International Journal of Radiation Oncology*Biology*Physics

View full text Add to dashboard Cite

show abstract

“…Higher levels reflect breakdown of myelin and membranes and/or increased concentrations of neurometabolites needed for repair processes, such as occur in traumatic brain injury [20–23]. Elevated Cho has been reported in white matter diseases [24, 25], frontotemporal dementia [26], mood disorders [27, 28], and in normal individuals with low positive affect [29]. We are aware of no studies linking Cho concentration with specific genetic variants.…”

Section: Introductionmentioning

confidence: 99%

Rare Copy Number Deletions Predict Individual Variation in Human Brain Metabolite Concentrations in Individuals with Alcohol Use Disorders

Yeo

Gangestad

Gasparovic

et al. 2011

Biological Psychiatry

View full text Add to dashboard Cite

Background Although variations in neurometabolite concentrations occur in diverse neuropsychiatric and neurodegenerative disorders, very little is known about the nature of underlying genetic influences. The current study investigated the importance of a specific type of genetic mutation, copy number variation (CNV), for neurometabolite concentrations in a bilateral anterior cingulate voxel. Methods These neurometabolic signals were quantified using proton magnetic resonance spectroscopy (1H-MRS): N-acetyl aspartate (NAA), creatine-phosphocreatine (Cre), glutamate/glutamine (Glx), myoinositol (mI), and phosphorylcholine-glycerol phosphorylcholine (Cho). Genetic data was collected using the Illumina 1M DuoBeadChip Array from a sample adults with alcohol use disorders (N = 146). Results The number of base pairs lost through rare copy number deletions (occurring in less than 5% of our sample) predicted lower NAA, Cre, mI, and Glx. More total rare deletions also predicted lower NAA, Cre, and Glx. Principal components analyses of the five neurometabolites identified two correlated components, the first comprised of NAA, Glx, and Cre, and the second comprised of Cho, mI, and to a lesser extent, Cre. The number and length of rare deletions were correlated with the first component, capturing approximately 10% of phenotypic variance, but not the second component. Conclusions These results suggest that mutation load affects neurometabolite concentrations, potentially increasing risk for neuropsychiatric disorders. The greater effect of CVNs on NAA, Glx, and Cre may reflect a greater sensitivity to the effects of mutations, i.e., reduced canalization, for neurometabolites related to metabolic activity and cellular energetics, due to extensive recent selection pressure on these phenotypes in the human lineage.

show abstract

“…However, elevated levels of lactate may be observed during the process of aggressive tumor development accompanied by angiogenesis (the evolution of the microenvironment) [49]. Also, the rate of tumor cell proliferation has been linked to choline and metabolites seen with phosphorus ( 31 P) MRS [50, 51]. …”

Section: Imagingmentioning

confidence: 99%

Non-invasive imaging of angiogenesis in head and neck squamous cell carcinoma

2010

View full text Add to dashboard Cite

Squamous cell carcinoma of the head and neck (HNSCC) is the seventh most common cancer in the United States. Angiogenesis, the process by which new blood vessels are formed, is an essential element at the basis of both tumor growth and metastases. This review discusses pertinent aspects of the role of imaging modalities in assessing angiogenesis and anti-angiogenic therapy in advanced HNSCC. KeywordsHead and neck squamous cell carcinoma; Angiogenesis; Anti-angiogenic treatment; Imaging techniques; Magnetic resonance imaging; Computed tomography; Positron emission tomography; Ultrasound; Molecular imaging Advanced head and neck cancersIn 2009, it was estimated that 48,010 new cases of head and neck (HN) cancer would be diagnosed in the United States and 11,260 deaths would occur due to the disease [1]. HN cancers generally stem from the mucosal epithelia of the oral cavity, pharynx, and larynx and have been etiologically associated with tobacco smoking and alcohol consumption [2]. Due to the wide variation in tissues of origin, HN cancer is a heterogeneous disease, representing a variety of histologies and differentiation patterns. The most common histology is squamous cell carcinoma (SCC), which accounts for greater than 90% of HN cancers. Early HN cancers are treated with radiation or surgery and have encouraging locoregional control [3,4]. After standard therapy (induction or concurrent chemotherapy administered with radiation or prior to surgery) for advanced HN disease, only 60% of patients survive 5 years [1]. Even with aggressive intervention, HN cancers often metastasize to the cervical lymph nodes before invading distant organs including the lungs. Despite advances in surgical techniques and oncologic treatment, the survival rate has remained the same over the past decade [1]. The two main reasons for poor outcome in advance HN cancer are a delayed diagnosis leading to locoregional failure and a late intervention with salvage treatment when disease recurs [5,6]. Therefore, even if the initial Correspondence to: Amita Shukla-Dave, davea@mskcc.org. NIH Public Access Author ManuscriptAngiogenesis. Author manuscript; available in PMC 2010 July 30. Angiogenesis and therapyAngiogenesis is a critical element of tumor growth and metastasis. It is a complex process, consisting of multiple steps concerning endothelial cell cessation, proliferation and migration of endothelial cells, and formation of new blood vessels [7]. During angiogenesis, vessels form to provide the expanding tumor with cells of endothelial origin, which divide much faster than normal endothelial cells. Once tumors grow beyond a diameter of a few millimeters, passive diffusion cannot sustain the viability of malignant cells anymore, and hence the formation of a new vascular network is necessary [7]. Tumors that grow beyond this stage, therefore, are capable of activating the "angiogenic switch." Induction of this angiogenic switch depends on how heavily the balance tips in favor of angiogenesis. The induction can occur at different st...

show abstract

Proton and Phosphorous MR Spectroscopy in Squamous Cell Carcinomas of the Head and Neck

Cited by 18 publications

References 43 publications

Tumor Metabolism and Perfusion in Head and Neck Squamous Cell Carcinoma: Pretreatment Multimodality Imaging With 1H Magnetic Resonance Spectroscopy, Dynamic Contrast-Enhanced MRI, and [18F]FDG-PET

Tumor Metabolism and Perfusion in Head and Neck Squamous Cell Carcinoma: Pretreatment Multimodality Imaging With 1H Magnetic Resonance Spectroscopy, Dynamic Contrast-Enhanced MRI, and [18F]FDG-PET

Rare Copy Number Deletions Predict Individual Variation in Human Brain Metabolite Concentrations in Individuals with Alcohol Use Disorders

Non-invasive imaging of angiogenesis in head and neck squamous cell carcinoma

Contact Info

Product

Resources

About